Naphthysine

Naphthyzine has a rapid and pronounced vasoconstrictive effect with a long duration.

[1], [2], [3]

Indications of the naphthysine

It is used to eliminate such pathologies:

• acute form of cold;
• acute or chronic stage of sinusitis;
• laryngitis;
• eustachitis in acute form;
• Use in the procedure of a rhinoscopy to facilitate its conduct;
• Puffiness in the larynx caused by irradiation or allergy;
• affecting mucosal hyperemia, triggered by the implementation of surgical procedures in the upper respiratory ducts.

Can also be used to eliminate ophthalmic diseases - chronic conjunctivitis and asthenopic disorders.

[4]

Release form

The drug is produced in the form of drops for the nose, in glass bottles with a capacity of 5 or 10 ml. Also can be produced in plastic bottles-droppers with a volume of 10, 15 or 20 ml. Inside the pack - 1 such a bottle.

Pharmacodynamics

The drug stimulates the activity of α2-adrenergic receptors, and in addition it reduces swelling, flushing and exudation in the mucosa, and has a vasoconstrictive effect on the nasal mucosa.

In people with a runny nose, the use of drops leads to a relief of the respiratory process through the nose.

After 5-7 days of using drugs, tolerance develops.

Pharmacokinetics

After applying the substance to the mucosa, it locally affects it, narrowing the surface vessels. Because of this, the absorption and resorptive effect of the active element does not develop. Partial absorption occurs in the case of prolonged and frequent use of drops, and this can cause an increase in blood pressure.

Dosing and administration

Drops are administered intranasally - they are instilled in each of the nostrils. Adults require 1-3 drops 3-4 times / day (0.1% solution).

In addition, it is used for the purpose of diagnosis. It is required to clean the nasal passages and to drip into each of them 3-4 drops of drugs or insert a swab in them, which before that was moistened in a 0.05% aqueous solution. Next, the tampons are left in the nose for 60-120 seconds.

If the medicine is used for inhalation procedures, a 0.05% solution is diluted using a saline solution in a ratio of 1k1. It is possible to perform such inhalations only after consulting a doctor.

The use of a pediatric form of a drug.

Children are usually prescribed an aqueous 0.05% solution - an age group of 1-6 years in a dose of 1-2 drops, and children aged 6-15 years - in a dosage of 2 drops. The procedure is performed 1-3 times a day. If required, a 0.025% solution can be used. To obtain it, a 0.05% Naphthysine solution is diluted with distilled water.

To eliminate ophthalmic disorders, the drug can be used only with the permission of the doctor. It is required to establish an appropriate diagnosis and clarify with the doctor whether it is possible to use Naphtizine for eye treatment. Usually, 0.05% solution is used for these procedures (1-2 drops, instilled into the conjunctival cavity), and they are carried out 1-3 times / day. The first of these procedures should be conducted under the supervision of the attending physician.

Bury the drug with the stuffed ears also allowed only with the permission of the doctor.

[5]

Use of the naphthysine during pregnancy

It is believed that the use of naphthyzine in pregnancy is allowed only in the presence of medicinal evidence and after a thorough assessment of the risk and benefits of its use. The same applies to the possibility of using drops during lactation.

Contraindications

Among the contraindications:

• the presence of high sensitivity with respect to the constituent components of the drug;
• diabetes;
• thyrotoxicosis;
• increased blood pressure;
• marked degree of atherosclerosis;
• tachycardia;
• combined use with MAOI, and also within 2 weeks after completion of their application;
• eye pathology in severe degree.

Side effects of the naphthysine

The use of drops can provoke such side effects associated with the local drug effect of drugs:

• hyperemia of a reactive nature;
• irritation in the nasal mucosa;
• when used for more than 7 days - swelling of the nasal mucosa and runny nose atrophic nature.

In addition, there may appear complications associated with the general medicinal effect: headaches, nausea, and tachycardia and an increase in the level of blood pressure (in persons with a predisposition to these disorders).

Overdose

When using the drug for a long time or a constant excess of the recommended portion in a person may increase blood pressure or develop a disorder of consciousness. In such cases, therapy should be discontinued and symptomatic measures taken.

People who have used Naphthyzin for a long time can get dependence on this drug. To get rid of it, you should consult a doctor, and then follow the individual therapeutic regimen assigned to them.

Intoxication in children should be treated solely by the doctor - by conducting symptomatic procedures.

Interactions with other drugs

It is forbidden to combine the medicine with MEO tools. After the end of the use of such drugs, the use of Naftizine can begin at least 2 weeks later.

The use of drops leads to the prolongation of the medicamentous effect of local anesthetics used in the procedures of surface anesthesia.

[6], [7]

Storage conditions

Naphthyzine is required to be kept out of the sunlight and out of reach of young children. Freezing is prohibited. Temperature marks during storage - within 10-25 ° C.

Shelf life

Naphthyzine can be used for 3 years after the manufacture of the therapeutic agent.

Application for children

It is forbidden to prescribe the drug to infants who have not reached the age of 1.

Analogues

Analogues of this drug are such drugs as Naphthyzine Bufus, Sanorin, Nafazoline, and also Nafazolin-Ferein.

Reviews

Naphthyzine receives many different reviews. He is considered an ambulance for the common cold and other diseases, but they also note that he is able to cause a strong dependence. Patients say that the drug is recommended to use with strong signs of the disease, but at the same time, you should avoid its use for several days in a row. It is very important to follow the drug instruction and take into account the contraindications of the medication.