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Mebsin retard
Last reviewed: 03.07.2025
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Mebsin retard is prescribed for the treatment of disorders associated with gastrointestinal function.
Indications Mebsina retarda
It is used in the treatment of the following disorders:
- as a symptomatic remedy for spasms and pain in the abdominal area, intestinal disorders and intestinal discomfort developing due to IBS;
- elimination of spasms in the gastrointestinal tract that are of secondary origin and caused by organic pathologies.
Pharmacodynamics
Mebeverine is a myotropic type spasmolytic with a selective effect on the smooth muscles of the digestive organs. The drug removes spasms without suppressing normal intestinal motility. Since this effect is not mediated by the autonomic nervous system, standard anticholinergic side effects do not develop.
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Pharmacokinetics
Suction.
The element mebeverine is fully and very quickly absorbed after taking the capsule orally. The prolonged release of the substance allows it to be taken twice a day.
Distribution processes.
After repeated administration of the drug, no significant accumulation of the substance occurs.
Exchange processes.
Meverine hydrochloride is mainly metabolized by esterases. These elements in the first stage of metabolism destroy ester compounds, forming mebeverine alcohol together with veratric acid in the process. The main product of metabolism in plasma is the substance DMCA.
The half-life of steady-state DMCC is 5.77 hours. After repeated administration of the drug (0.2 g twice a day), the peak value for DMCC was 804 ng/ml. It takes about 3 hours to reach this value. The level of relative bioavailability of the drug has an average proportion of 97%.
Excretion.
Mebeverine is completely metabolized and its breakdown products are almost completely excreted. Veratric acid is excreted in the urine, and mebeverine alcohol is excreted through the kidneys in the form of UC or DMCA.
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Dosing and administration
The medicine is prescribed for oral administration. The capsules should be washed down with plain water (at least 0.1 l), swallowing them whole, without chewing. This is due to the fact that a special capsule coating provides a prolonged release of the active substance.
Children over 10 years of age and adults are required to take 1 capsule of the drug twice a day (in the morning and in the evening).
The duration of taking the drug is not limited. If you miss a dose, you must take a new dose at the standard time, and take the missed dose additionally with the next prescribed dose.
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Use Mebsina retarda during pregnancy
It is prohibited to use Mebsin retard during pregnancy or breastfeeding.
Side effects Mebsina retarda
When using the drug, the development of side effects on the skin surface was mainly recorded, but other disorders were also observed:
- lesions of the subcutaneous layer and epidermis: Quincke's edema, rashes (sometimes hemorrhagic), hyperthermia, urticaria and swelling of the face;
- disorders of the nervous system: dizziness, headaches and depression;
- digestive disorders: constipation or diarrhea;
- systemic symptoms: development of intolerance (anaphylactic symptoms).
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Overdose
In theory, CNS excitation may develop due to poisoning. No negative effects occurred during overdose, or they were weak and passed quickly. The disorders that arose were of cardiovascular or neurological nature.
Mebsin retard has no antidote, so symptomatic measures must be taken. Gastric lavage should only be performed in cases of poisoning with several different drugs, diagnosed within 1 hour of their use. Procedures to reduce absorption are not considered vital.
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Storage conditions
Mebsin retard should be kept in a place out of reach of small children. Temperature values – no more than 30°C.
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Shelf life
Mebsin retard can be used for 2 years from the date of manufacture of the drug.
Application for children
It should not be used by children under 10 years of age due to the high level of active ingredient inside the medicine.
Analogues
Analogues of the drug are Meverin, Duspatalin, and Aspazmin.
Reviews
Mebsin retard works great for inflammations developing inside the gastrointestinal tract, and also eliminates spasms and pain – this is stated in patient reviews regarding this medicine.
Attention!
To simplify the perception of information, this instruction for use of the drug "Mebsin retard" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.