You can begin treatment before the pathogenic microbial pathogen is detected. The method of administration and the size of the dose are determined taking into account the severity of the infectious process, the sensitivity of the microbe, and in addition the functional state of the kidneys of man. The route of intravenous administration is usually prescribed for people with severe forms of infection, or for life-threatening infectious processes (especially at the risk of a shock condition).
Dosages for children weighing more than 40 kg and adults (with normal kidney function):
- with moderate and mild forms of infection in the urinary tract - a single dose (iv or IM) is 0.5-1 g (with an interval of 12 hours);
- other infectious processes (moderate or mild form) - one-time dosage is 1 g (IM or IV) with an interval of 12 hours;
- severe forms of infections - dosage is 2 g (intravenous injection) with an interval of 12 hours;
- for life-threatening infections - a single dose is 2 g (iv administration) at an interval of 8 hours.
As a prophylaxis of the development of infection during surgery, it is necessary to inject an IV solution in the amount of 2 g (for half an hour). At the end of the procedure, another 0.5 g of metronidazole is to be injected intravenously. This solution can not be administered simultaneously with Maxi cef. The infusion system must be thoroughly rinsed before using metronidazole.
With prolonged (12+ hours) surgical procedures 12 hours after the introduction of the 1st dose, it is required to re-administer (in the same size) with the subsequent injection of metronidazole.
Children from 2 months are allowed to administer the drug in doses not exceeding the recommended adults. The average level of children's dose (in children weighing less than 40 kg) in the treatment of uncomplicated or complicated processes in the urinary tract (this includes pyelonephritis) and empirical therapy of febrile neutropenia, and also in the treatment of pneumonia and uncomplicated infectious processes (in soft tissues with the skin) is 50 mg / kg every 12 hours.
People with a bacterial form of meningitis and febrile neutropenia are prescribed administration of a solution in the amount of 50 mg / kg every 8 hours.
The therapeutic course lasts for 7-10 days on average, but it can be longer in the treatment of severe forms of infections.
People with functional renal disorders (with a QC less than 30 ml / minute) require a change in the dosage regimen. The size of the initial dose remains the same as that prescribed for people with a healthy renal function. But the size of the supporting doses is selected taking into account the level of MC:
- at a rate of 10-30 ml / minute the recommended dosages are - 1 g after every 12 hours; 1 g after every 24 hours; 0.5 g after every 24 hours;
- at a level of less than 10 ml / minute - 1 g with an interval of 24 hours; 0.5 g with an interval of 24 hours; 0.25 g with an interval of 24 hours.
In hemodialysis procedures for a period of 3 hours from the body excreted about 68% of the total number of introduced cefepime. At the end of each procedure, it is required to inject a second injection equal to the initial dose. When using peritoneal dialysis, the drug is administered at the average recommended dosages (0.5, 1 or 2 g, the exact number depends on the level of severity of the pathology), and the interval between the procedures is 48 hours.
Rules for the preparation of medicinal solution. To prepare the solution for intravenous administration, it is necessary to dissolve the powder in sterile water used for injections (10 ml volume), and also in a solution of glucose (5%) or a solution of sodium chloride (0.9%). Intravenous intravenous injection of drugs is carried out for 3-5 minutes. To introduce it through the infusion system, it is required to mix the prepared solution with other solutions for intravenous injections, and then to enter a minimum of half an hour.
Maxi cef solution with a concentration of 1-40 mg / ml is compatible with the following solutions (administered parenterally): injection solution of sodium chloride (0.9%), injection solution of glucose (5% or 10%), injection solution of sodium lactate M / 6. In addition, a mixture of injection solutions of sodium chloride (0.9%) and glucose (5%), as well as a mixture of injectable solutions Ringer-lactate and glucose (5%).
To make a solution for intramuscular injections, the powder should be dissolved in sterile water (volume 2.5 ml), and in addition in the injectable solution of glucose (5%) or sodium chloride (0.9%). A bacteriostatic injection liquid with phenylcarbinol or paraben is also used, mixed with a solution of lidocaine hydrochloride (0.5% or 1%).