Maninil

Maninil - antidiabetic remedy from the category of derivatives of sulfonylureas of the 2nd generation. Has extrapancreatic as well as pancreatic effect.

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Indications of the maninila

It is used for the 2nd type of diabetes mellitus, when diet therapy did not bring the effect. The drug is used in combination with insulin, regularly monitoring blood sugar.

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Release form

The release occurs in the form of tablets (3.5 or 5 mg). Inside the glass bottle are 120 tablets. In a pack of 1 bottle.

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Pharmacodynamics

Glibenclamide promotes the activation of insulin production and enhances the insulin-releasing effect of glucose. The effect of the drug increases the cellular sensitivity of the pancreas with respect to the glucose-dependent insulinotropic polypeptide.

Increasing the sensitivity of receptors to insulin causes the development of extrapancreatic effects of the drug.

Medicinal doses of Maninil reduce the likelihood of such disorders as cardiopathy with retinopathy, as well as nephropathy. In addition, the drug reduces the mortality associated with diabetes mellitus.

The drug has a cardioprotective and antiarrhythmic effect, so it is allowed to use it for diabetics who also suffer from coronary artery disease.

The substance glibenclamide reduces platelet aggregation and prevents the development of diabetes-related complications on the vessels.

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Pharmacokinetics

The drug effect lasts for 12 hours. Absorption of the micronized form of the substance from the digestive tract occurs more quickly, as a result of which the medicine has a milder and physiological effect on the body.

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Dosing and administration

Selection of dosages is carried out individually, taking into account the severity of the pathology, glucose and age of the patient. The average daily portion is about 2.5-15 mg. Take glibenclamide in the morning and evening, before eating (for 30 minutes). Tablets can not be chewed.

For a day, a maximum of 15-20 mg of medication is allowed, not more.

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Use of the maninila during pregnancy

Apply Maninil during pregnancy is prohibited.

Contraindications

Among the contraindications:

• diabetes mellitus type 1;
• comatose state or precoma of the diabetic type;
• ketoacidosis;
• the presence of injuries or extensive burns on the body;
• coma of a hyperosmolar character;
• pathology of infectious genesis;
• leukopenia;
• kidney / liver failure;
• microangiopathy;
• an obstruction of an intestine.

Caution is required in case of use with adrenal insufficiency, fever syndrome, alcoholism, as well as pathologies in the thyroid gland.

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Side effects of the maninila

As a result of an incorrect diet or a violation of the dosage regimen of the drug, hypoglycemia may develop. Among other side effects: fever, allergic symptoms, weight gain, dyspepsia, arthralgia. In addition, proteinuria, cholestasis, neurological disorders, liver function problems, hemopoietic disorders, polyuria and porphyria on the skin (late stage) are developing. There may appear photosensitivity and headache, severe fatigue and a disorder of taste buds.

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Overdose

Among the signs of poisoning: hyperhidrosis, tremor, a feeling of hunger, problems with vision, speech and consciousness, cerebral edema and other symptoms of hypoglycemia. In addition, the rapid pace of heartbeat, a feeling of irritability, a state of depression, insomnia, and coma.

To eliminate the disturbances, it is first necessary to consume glucose. If the victim is unconscious, he is bolusily administered IV in the dextrose method, and in addition, diazoxide with glucagon is used. Further, at intervals of 15 minutes, the blood sugar values should be checked. To prevent relapse of hypoglycemia, it is required to feed the affected person with food, which contains many easily assimilated carbohydrates. In the case of cerebral puffiness, mannitol and dexamethasone are used.

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Interactions with other drugs

Among the drugs that potentiate the properties of Maninil: IAPF, fibrates with NSAIDs, antimycotics, coumarin anticoagulants, and MAO, antituberculosis drugs, pentoxifylline with salicylates, tetracycline with biguanides and cyclophosphamide, chloramphenicol with fenfluramine, anabolic, β-adrenoblockers, disopyramide with acarbose and pyridoxine, and in addition, reserpine with bromocriptine and insulin with allopurinol.

The properties of the drug are weakened when combined with such drugs: barbiturates with anticonvulsants, BCCC, adrenostimulators and diuretics of the thiazide type. In addition, chlorothalidone, carbonic anhydrase inhibitors, baclofen with furosemide and glucagon, asparaginase with terbutaline, ritodrine, isoniazid and danazol, as well as morphine with diazoxide, morphine with rifampicin, salbutamol and thyroid hormones. This group includes lithium salts, chlorpromazine with niacin, estrogens and oral contraception.

The effect of the drug, as well as its reabsorption, are enhanced when taken together with high dosages of vitamin C and ammonium chloride.

Combined use with drugs that suppress hematopoiesis within the bone marrow increases the likelihood of myelosuppression.

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Storage conditions

Maninil must be kept out of the reach of children. The temperature should not exceed 25 ° C.

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Special instructions

Reviews

Maninil is a fairly popular tool - it is considered to be quite effective, and at the same time inexpensive. Well helps in the treatment of type 2 diabetes.

At the initial stage of the drug use, negative reactions may occur, but they disappear on their own after a short period of time.

Shelf life

Maninil is allowed to be used for 3 years from the date of manufacture of the drug.

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