The drug is quickly absorbed after oral administration, reaching peak plasma values after 2 hours (in case of fasting). In the case of reception, along with food, the suction rate decreases slightly, but its degree remains the same. Individual changes in the rates of absorption should not have a drug-significant effect on the equilibrium plasma concentration of drugs in the case of daily use of the 1st pill.
About 90-95% of the equilibrium drug index is reached after 7 days after drug use. There is no evidence that the pharmacokinetics of the active substance depends on the size of the dosage or the time of administration. Synthesis of anastrozole with a plasma protein is 40%.
Extensive metabolism of the active component is observed in women who are in the postmenopausal period. The very process of metabolism occurs by means of hydroxylation, N-dealkylation, and also glucuronization.
The excretion of the substance is rather slow, the plasma half-life is 40-50 hours. Urine excreted less than 10% of the dosage (unchanged substance) - it occurs in the period of 72 hours after taking drugs. The products of decay are mostly excreted in the urine. The main decay product (triazole), which can be found in urine, as well as plasma, is not an aromatase inhibitor.