Makhachkala

Medaxone is an antibiotic from the category of cephalosporins administered by the parenteral route. Has bactericidal activity.

Indications Medaksona

It is used to treat various disorders:

• infections, provoked by the activity of microflora, which is sensitive to ceftriaxone (among such lesions, affecting respiratory ducts, LOP-organs, joint bones, peritoneum, epidermis, kidneys, urethra and connective tissues);
• sepsis or meningitis, as well as infections in the urogenital area;
• pathologies that are of an infectious nature, in people with weakened immune defenses.

It is prescribed to prevent the occurrence of infections in the periods after the surgical procedures.

Release form

The release is made in the form of a lyophilizate for the manufacture of injections (intravenous or intramuscular), inside flasks of glass with a capacity of 500 or 1000 mg. Inside of packet 1 such a bottle.

Pharmacodynamics

The effect of the drug is based on suppression of cell wall binding processes. The drug has bactericidal activity against a large range of microbes, and at the same time demonstrates resistance against enzymes produced by bacteria (cephalosporinase with penicillinases).

Pharmacokinetics

Element ceftriaxone after parenteral use at high speed is absorbed and passes into the tissues and body fluid.

The average half-life is 8 hours; in elderly people this period is longer almost twice.

The level of bioavailability after intramuscular injection is 100%. The bactericidal effect of drugs with respect to sensitive bacteria continues for a period of 24 hours. The synthesis with protein is 85-95%.

Excretion of unchanged ceftriaxone with urine is 50-60%, and another 40-50% is excreted with bile.

Dosing and administration

The medication should be administered intravenously or intramuscularly. For a day, usually 1-2 g of the drug is administered (1-fold procedure). Carry out shots at intervals of 24 hours. Sometimes (with severe forms of severity of pathologies or in the presence of bacteria with moderate sensitivity), daily dosage is allowed to be increased up to 4 years.

Adolescents over 12 years of age are injected with a dose calculated according to the scheme of 20-75 mg / kg. If the weight of the child is more than 50 kg, the medication is administered in adult dosages. Dimensions of doses for newborns should not be above 50 mg / kg.

The duration of the treatment cycle is determined by the type of pathogenic bacterium-pathogen, as well as by the nature of the pathology. Usually it lasts for 4-14 days.

To prevent the emergence of infections after surgical procedures, 60 minutes before the start of the operation, 1-time administration of the drug in a dose of 1-2 g.

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Use Medaksona during pregnancy

It is forbidden to use Medaxone during pregnancy or lactation.

Contraindications

The main contraindications:

• presence of strong sensitivity to the drug;
• inadequate kidney or liver function;
• presence in the anamnesis of bleeding or diseases affecting the gastrointestinal tract (ulcerative form of colitis or enteritis).

Side effects Medaksona

The use of medication can lead to the emergence of certain side-effects:

• local manifestations of allergies: hives, itching, febrile condition and rashes. Occasionally there is eosinophilia, MEE, bronchospasm, anaphylaxis and serum sickness;
• Digestive disorders: vomiting, constipation, stomatitis, swelling, nausea or diarrhea, and besides this enterocolitis, stomach pain, taste and dysbiosis;
• disorders of the hematopoietic function: neutron, leuko- or granulocytopenia, hemolytic form of anemia, and hypocoagulation;
• problems with the work of the kidney and urinary system: hematuria or anuria, azotemia or oliguria, and in addition an increase in the blood values of urea;
• other: pain arising during the vein, nosebleeds, dizziness, phlebitis, headaches and candidiasis.

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Overdose

When intoxication with Medaxone may increase the severity of negative symptoms.

Interactions with other drugs

Because of the lack of compatibility between ceftriaxone and aminoglycosides, they should be used separately, while not exceeding the size of the prescribed dosages.

Ceftriaxone also does not have compatibility with ethyl alcohol.

Chemical incompatibility does not allow mixing the drug with other antibiotics inside a single syringe or infusion capacity.

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Storage conditions

Medaxone should be kept at temperature values not exceeding 25 ° C.

Shelf life

Medaxone can be used within 24 months of the release of the therapeutic agent.

Analogues

Analogues of the drug are drugs Axon, Megion, Lifaxon, Azaran with Betasporin, and besides Biotrakson, Longacef, Steritsef and Lendacin with Movigip. The list also includes Rocefin, Triacson, Cefatrine, Torotsef with Chison and Oframax, and in addition, Tertsef, Cefogram, Forcef, Cephson with Cefaxon, Ceftriaxone and Ceftriaxone sodium, and Ceftriabal.

Reviews

Medaxone receives positive feedback from patients who note its high therapeutic effectiveness. Although there are also people who did not bring the desired result. But in these cases, the commentators did not mention the tests that help determine the sensitivity of the microbial microflora relative to the drug, which is very important for the effectiveness of antibiotic therapy.