Macropen

Macropen is a macrolide antibiotic of a wide range of effects.

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Indications Macropen

Among the indications are the infectious processes triggered by the activity of drug-susceptible pathogenic microbes:

• in the respiratory tract;
• in the genitourinary system;
• on the skin or mucous membranes;
• Campylobacter-induced enteritis;
• to eliminate pertussis and diphtheria;
• for the treatment of patients with an allergy to penicillin antibiotics.

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Release form

Available in the form of tablets or also a powder for the suspension. The volume of tablets is 400 mg. One packet contains 16 tablets. The volume of the vial for making the suspension is 115 ml.

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Pharmacodynamics

The active ingredient is medecamicin. It affects: gram-positive microbes (such as staphylo- and streptococci, listeria with clostridia, and also corynobacteria), and in addition intracellular organisms (chlamydia and mycoplasma, and in addition legionella and ureaplasma) and gram-negative microbes (Campylobacter and Helicobacter, as well as moraxella, bacteroids and influenza rod).

Pharmacokinetics

After ingestion, Macropen is completely and quickly absorbed from the digestive tract. The peak concentration reaches 1-2 hours later. The medicine accumulates in the affected areas, and besides this in the skin and bronchial secret. Drug withdrawal occurs mainly through the liver.

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Dosing and administration

The suspension is usually used for children. Reception is performed twice a day, and the dosage should be calculated depending on the weight of the baby:

• with a weight less than 5 kg, the dose is 3.75 ml (131.25 mg, respectively);
• 5-10 kg - a dosage of 7.5 ml (correspondingly 262.2 mg);
• in the range of 10-15 kg - 10 ml (respectively 350 mg);
• in the range of 15-20 kg - a dose of 15 ml (525 mg, respectively);
• weight in the range of 20-25 kg - a dose of 22.5 ml (respectively 787.5 mg).

To make the suspension, water (100 ml) is added to the powder in the vial.

Children weighing more than 30 kg, as well as adults are required to drink tablets - 1 tablet 3 times a day.

During the day, children can take no more than 30-50 μg / kg of Macrofene. The daily dosage should be divided into 2 parts. Adults per day can take a maximum of 1.6 grams of medication - the dosage for the day is divided into 3 parts.

The treatment course generally lasts a maximum of 1-1.5 weeks, only with chlamydial infection this period can be prolonged up to 2 weeks.

Use Macropen during pregnancy

Macropean is allowed to use during pregnancy, but it is still recommended to prescribe it only when the possible therapeutic benefit exceeds the risk of negative consequences for the fetus.

Contraindications

Among the contraindications: the individual intolerance of the active ingredient, as well as other excipients contained in the medication, and in addition, in cases where the patient has severe hepatic insufficiency.

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Side effects Macropen

As a result of taking medication, such adverse reactions can occur: a worsening of appetite (occasionally it can go to the development of anorexia), a feeling of nausea (sometimes vomiting), an allergy manifested on the skin (accompanied by eosinophilia), and an increase in the number of hepatic enzymes.

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Overdose

Specific signs of an overdose Macroben does not exist - if the recommended dose is exceeded, vomiting may begin with nausea.

As a treatment should be used sorbents to speed up the process of removing the drug from the body, and in addition to carry out procedures to eliminate unpleasant symptoms.

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Interactions with other drugs

Do not combine Macroben with drugs based on carbamazepine or ergot, because the drug can increase their level in the blood, resulting in changes in the transformation processes in the liver.

In addition, it is forbidden to use Macropen on the background of treatment with warfarin and cyclosporine.

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Storage conditions

The medicine (both tablets and granules) is required to be kept out of the reach of children and moisture. The temperature conditions are a maximum of 25 ° C. It is recommended to keep the slurry in the refrigerator.

Shelf life

Macropleen is allowed to be used for 3 years from the date of manufacture of the medicine.

Ready suspension is allowed to apply for 2 weeks (if the drug is contained in the refrigerator), or the 1-st week (in conditions of temperature not more than 25 ° C).

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