Macmiror complex

Macmiror complex is a combination of nystatin and nifuratel. Its properties include antiprotozoal, fungicidal and antimicrobial.

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Indications Macmiror complex

Indications for use include vaginal infections caused by bacteria sensitive to the properties of the drug. Among them:

• urogenital trichomoniasis;
• thrush;
• bacterial infections in the urogenital area;
• Chlamydia infections (local therapy).

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Release form

Available in the form of vaginal suppositories. One blister pack contains 8 or 12 suppositories. One pack contains 1 blister.

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Pharmacodynamics

Nifuratel is a 5-nitrofuran derivative with fungicidal and antimicrobial properties. It is an oxygen acceptor, which allows it to destroy the respiration of microbial cells, and in addition, it can reduce the activity of individual respiratory enzymes of cells, as a result of which pathogenic microbes die. The intracellular nitro group of this substance is restored, as a result of which it acquires cytotoxic properties. The combination of these actions allows nifuratel to exhibit activity against aerobes, as well as Candida fungi. Nitrofurans also suppress the process of nucleic acid synthesis, thereby interfering with the replication of DNA and RNA (but to a much lesser extent) of microbes.

Nystatin is an antibiotic with antimycotic properties. It acts as follows - it competitively replaces sterol structures in the fungal plasma membrane. As a result, the cell membrane loses its protective properties, which leads to its death.

Since the drug has a low level of toxicity and highly selective antimicrobial activity, its use does not cause the development of vaginal dysbacteriosis.

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Dosing and administration

The suppositories should be inserted into the vagina one per day. It is best to carry out the procedure in the evening, before going to bed. The treatment course lasts 8 days. In some cases, the attending physician may adjust the dosage, as well as the duration of the course.

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Use Macmiror complex during pregnancy

Macmiror Complex can be used during pregnancy only on doctor’s prescription – in cases where the possible benefit from treatment exceeds the possibility of negative consequences for the fetus.

Contraindications

Contraindications include: individual intolerance to the components of the drug, as well as use in childhood.

Side effects Macmiror complex

The drug has no side effects, except for the rare development of allergies, which manifests itself in the form of a skin rash and itching.

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Storage conditions

The medicine should be kept in a place protected from sunlight and moisture. Temperature conditions during storage are no more than 25 degrees.

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Shelf life

Macmiror complex is permitted to be used for 3 years from the date of manufacture of the medicine.

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