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Leykaran
Last reviewed: 23.04.2024
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Laykaran demonstrates antitumor and cytostatic activity.
Indications Lakerana
It is used for the following pathologies:
- lymphogranulomatosis ;
- chronic lymphocytic leukemia;
- lymphomas having a malignant form (for example, lymphosarcoma);
- primary macroglobulinemia.
Release form
The release of therapeutic agent is made in tablet form, in the amount of 25 pieces inside a glass vial; in a pack - 1 such bottle.
Pharmacodynamics
Chlorambucil is an aromatic derivative of nitrogenous mustard gas, which during therapy has a bifunctional alkylating effect.
Alkylation is carried out during the formation of high-activity ethyleneimonium radicals. During this process, cross-synthesis between these radicals, as well as the DNA-helix, is carried out, as a result of which its replication is disrupted.
Pharmacokinetics
There is a good absorption of drugs from the gastrointestinal tract. Indicators Cmax of the active component are recorded after 0.5-2 hours after administration. Intlasma protein synthesis equals 99%. Excretion of chlorambucil from the blood plasma takes place after approximately 90 minutes.
Metabolic processes develop inside the liver, fully and at high speed. Excreted substance mainly through the kidneys in the form of metabolic products. The component does not overcome the BBB, but is able to penetrate the placenta.
Dosing and administration
Tablets must be taken whole, orally. Usually, the medicament is part of a complex treatment, which is why an extremely experienced medical specialist should select the dosage regimen and dosing regimen.
In case of lymphogranulomatosis, Leikeran is used as monotherapy. During the day, an average of 0.2 mg / kg of the substance is required. The entire treatment cycle usually lasts 1-2 months.
In other situations, the dosage is calculated, taking into account the individual characteristics and weight of the patient. The duration of therapy should be selected by the doctor.
[1]
Use Lakerana during pregnancy
Assigning to pregnant or lactating women is prohibited.
Contraindications
It is contraindicated to use the drug in persons with severe intolerance in his regard.
With great care it is used in the following situations:
- severe leuco- or thrombocytopenia, as well as suppression of bone marrow activity;
- recently transferred or currently diagnosed chickenpox;
- herpes zoster character;
- infections that are acute and fungal, viral or bacterial in origin;
- bone marrow infiltration of tumor cells;
- gout;
- urate nephrolithiasis;
- epilepsy or head injury;
- diseases affecting the kidneys or liver, to a severe degree.
Side effects Lakerana
With the introduction of Lakeran, there may be such violations:
- jaundice, myelosuppression, liver disorders and gastrointestinal disorders;
- convulsions, fever, epidermal rashes;
- aseptic cystitis, amenorrhea;
- polyneuropathy or pneumonia.
Overdose
With intoxication, ataxia, increased excitability, curable pancytopenia and relapses of epileptoid seizures are noted.
The medicine has no antidote. Gastric lavage is carried out, and in addition, the vital functions of the body are monitored and maintained. It is necessary to monitor blood tests and carry out all necessary activities, taking into account the developing negative signs.
Interactions with other drugs
Combining drugs with substances that have the ability to suppress blood-forming processes, can lead to a potentiation of myelotoxicity.
When used together with anti-gouty drugs, their dosage must be changed, because chlorambucil increases the blood levels of uric acid.
Combination with haloperidol, MAOI, maprotiline, and in addition with phenothiazines, tricyclics and thioxanthenes often reduces the seizure threshold, and at the same time increases the likelihood of seizures of seizures.
Simultaneous use with virus-inactivated vaccines reduces the production of antibodies as a reaction to the vaccine used. When using live virus vaccines, potentiation of negative symptoms, weakening of antibody production and development of other negative manifestations are possible.
Storage conditions
Lakeran must be kept in a closed area from children and sunlight. Temperatures - in the range of marks 2-8 ° C.
Shelf life
Leykaran can be used for a 3-year term from the date of manufacture of the drug.
Analogs
Analogues of the substance are drugs Chlorbutin and Chlorambucil.
Attention!
To simplify the perception of information, this instruction for use of the drug "Leykaran" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.