Levot

Levotion is a drug with a large range of bactericidal and antimicrobial effects.

[1], [2], [3], [4]

Indications of the levolety

It is used to eliminate pathologies that have inflammatory or infectious origin:

• tuberculosis;
• prostatitis of bacterial origin;
• infectious processes affecting respiratory ducts, kidneys and urogenital system (eg, pyelonephritis );
• infections in the intra-abdominal area;
• pulmonary inflammation or sinusitis;
• skin lesions having an infectious nature.

Release form

Release of the drug occurs in tablets with a volume of 0.25 or 0.5 g, 10 pieces inside a blister pack. In a pack - 1 such blister.

Tablets with a volume of 0.75 g, 5 or 10 pieces inside the blister plate are also produced. In the box - 1 such a plate.

[5], [6]

Pharmacodynamics

The therapeutic compound contained in the preparation is a blocker of topoisomerase 2 (DNA gyrase), and in addition to this topoisomerase 4. This contributes to the disruption of the process of supercoiling, triggering the binding and "stitching" of the breaks that appear in the DNA. As a result, morphological transformations begin inside the cell walls, cytoplasm and membranes.

The drug actively acts against anaerobes (phageilis and veyonelly bacteroids), gram-positive (staphylococcus and diphtheria corynebacterium) and gram-negative (Morgan bacteria and Escherichia coli) aerobes, as well as pathogenic bacteria that have sensitivity, moderate sensitivity and resistance.

Pharmacokinetics

Absorption.

After ingestion, the drug is absorbed almost completely and quickly. Peak plasma values are noted after a lapse of 1 hour after ingestion. The level of bioavailability is almost 100%.

Element levofloxacin has linear pharmacokinetic parameters within dosages of 50-600 mg. The use of food has a slight effect on the absorption of drugs.

Distribution processes.

About 30-40% of the drug is synthesized with a blood serum protein. Cumulation of levofloxacin, when administered once a day, 0.5 g of drugs does not have clinical significance, so it can be ignored. It is assumed that an insignificant cumulation can be observed with a double use of 0.5 g of medicine per day. Stable distribution values are noted after a lapse of 3 days.

Distribution processes inside liquids and tissues.

The peak values of the preparation inside the bronchial mucosa and the secretion of the bronchial epithelium after ingestion of 0.5 g of the substance are 8.3, respectively, and 10.8 μg / ml, respectively.

Inside the lung tissue after oral ingestion of 0.5 g LS, the peak value was about 11.3 μg / ml. It takes 4-6 hours to reach it. The indices of matter inside the lungs were always higher than inside the blood plasma.

Inside the vesicle liquid, the peak level of the substance (application of 0.5 g of the drug once or twice daily) was 4 and 6.7 μg / ml, respectively.

The medicine does not go well inside the liquor.

Inside the prostate tissues, the average values of drugs (after eating once a day 0.5 g of the drug for 3 days) were 8.7; 8.2, and 2 μg / g after 2, 6 and 24 hours, respectively. The average proportions of the substance within the prostate / blood plasma are 1.84.

Average values of the substance inside the urine after 8-12 hours after a single use of a portion of 0.15 or 0.3 g of LS were respectively 44, 91, and 200 μg / ml, respectively.

Metabolic processes.

Metabolism of the drug is extremely insignificant, among the decay products of the substance - dysmethyl-levofloxacin, and in addition levofloxacin N-oxide. These elements make up less than 5% of the total amount of medicine excreted in the urine.

Excretion.

After oral administration, the substance is excreted from the blood plasma rather slowly (half-life is about 6-8 hours). The process of excretion of drugs is mainly performed by the kidneys (approximately 85% of the intake).

There is no discernable difference in the pharmacokinetic properties of levofloxacin after ingestion or intravenous administration.

Dosing and administration

It should be noted that the size of the portion of the medicine, as well as the mode of its use, are selected taking into account the patient's condition, the severity of his pathology, and also the sensitivity of pathogenic microbes to the active elements of the medicine. On average, the course of therapy by Levonet lasts a maximum of 2 weeks.

To use the drug in a dosage of 0.25 or 0.5 g is necessary before meals or in between, squeezed with plain water (tablets can not be chewed). Like other antibiotics, the Levolet drug should be taken at least 48 hours after laboratory confirmation of the destruction of pathogenic bacteria and stabilization of normal temperature.

For therapy in people with problems in kidney activity, it is required to change the dosage size of drugs.

[7]

Use of the levolety during pregnancy

Levon can not be prescribed to pregnant women or lactating women.

Contraindications

Among the contraindications:

• the presence of high sensitivity with respect to quinolones, and in addition to these medicinal elements;
• seizures of epilepsy;
• lesions affecting tendons.

Extremely cautious medicine is prescribed for elderly patients and persons with a deficiency of the G6PD element inside the body.

Side effects of the levolety

The drug is capable of provoking the development of such side effects:

• disorders of the hematopoietic function: anemia or leukopenia;
• disorders of the digestive organs: diarrhea, loss of appetite, abdominal pain, nausea, and dysbiosis;
• problems in the work of SSS: tachycardia, vascular collapse;
• disorders of the NA: dizziness, depression, convulsions and paresthesia, headaches, and in addition a feeling of drowsiness;
• Other: impairment of renal function, hypoglycemia, rhabdomyolysis, exacerbation of porphyria, and taste, visual and olfactory disorders and hepatitis;
• problems in the work of muscles and skeleton: a rupture in the tendon, tremors in the upper limbs and pain in the muscles.

In addition, the use of drugs can lead to the appearance of allergy symptoms - such as rash, itching, reddening of the epidermis, and at the same time phlebitis, anaphylaxis, vasculitis, fever and TEN. It also includes hives, pneumonitis of allergic origin, Stevens-Johnson syndrome and others.

Overdose

In case of drug poisoning, the victim may experience such manifestations as convulsions, nausea, dizziness, sensation of confusion, prolongation of the QT-interval and damage in the area of the gastrointestinal mucosa.

Interactions with other drugs

The effectiveness of the therapeutic effect of drugs reduces antacids, and in addition to this drug, which contains aluminum, iron salts, sucralfate and magnesium.

It is forbidden to combine Levot with theophylline, cimetidine, NSAIDs, GCS and medications that affect the secretion of tubules.

[8]

Storage conditions

Levonet need to be kept in a dark place, closed from penetration of young children. Do not freeze the medicine. Temperature values are a maximum of 25 ° C.

[9]

Shelf life

Levotion is allowed to be used for 2 years from the date of release of the therapeutic agent.

Application for children

Medication can not be used in people who have not reached the age of 18 years.

Analogues

Analogues of the drug are drugs Glevo, Fleksid, Ivatsin with Leflobact and Levoflox, and besides this Levofloxabol, Remedia, Ecolevid and OD Levoks with Tanfloomedom.

Reviews

Levonet gets enough polar feedback about his drug effectiveness. The opinions of the clients are divided - some say that the medicine works quite qualitatively and is inexpensive, but others note that it has quite a few side effects, because of which the benefit of the medication is put under great doubt.