Levasil

Levasil is a medicine with a hepatotropic effect.

Indications of the levasila

It is used for auxiliary therapy of inflammation and toxic lesions affecting the liver: such as chronic hepatitis (this includes steatohepatitis ), as well as fatty hepatic dystrophy.

In addition, it is prescribed for the prevention of the development of hepatic intoxication (under the influence of alcoholic beverages or medications).

Release form

Release of the medicine is carried out in capsules with a volume of 70 mg, in the amount of 10 pieces inside the strip. The box contains 3 such strips.

Also produced in capsules with a volume of 140 mg, in the amount of 6 pieces inside the strip. In a pack - 5 such strips.

Pharmacodynamics

Levasil is a drug that improves the performance of a weakened liver disease. Its medicinal effect is manifested by the ability to influence the permeability of the walls of the hepatic cells.

Vitamins, which are part of the B complex, are constituent elements of the drug - these are the functional components of intermediate metabolic processes. They act as coenzymes in the reactions of the metabolism of carbohydrates and proteins, and together with this they have a hepatoprotective effect.

Vitamins increase the rate of recovery of the damaged hepatic parenchyma. In addition, because of hepatopathies, the ability of the liver to store vitamins from category B is significantly impaired, as a result of which their deficiency inside the body develops.

The use of Levasil, which contains the vitamin complex (B), helps to compensate for the deficiency.

Pharmacokinetics

After ingestion, the bulk of the silymarin substance is excreted along with the bile, and then enters the process of enterohepatic recirculation.

Excretion of silibinin mainly occurs with the help of kidneys, and metabolic products (glucuronides and sulfates), having a related appearance, are also noted in bile. Excretion of silibinin lasts approximately 24 hours. Most of the consumed portion (about 20-40%) of silibinin is excreted with bile. Only about 3-7% of the total portion is excreted by the kidneys.

Dosing and administration

The medicine should be taken after eating. The size of the portion and the duration of therapy are selected by the treating doctor individually, taking into account the type of illness and the severity of its course.

The standard portion size is the intake of the 1st capsule with a volume of 70 or 140 mg 2-3 times a day. In the future, it is allowed to reduce the portion size to 1-2 per day.

Swallow capsules without prior chewing. Thus it is necessary to wash down a medicine with simple water (0,5 glasses).

[1]

Use of the levasila during pregnancy

There is no information on the safety and therapeutic effectiveness of the drug when used in lactation or pregnancy. Therefore, it is forbidden to assign it to this group of patients.

Contraindications

Among the contraindications:

• the presence of high sensitivity with respect to the elements of the drug;
• encephalopathy in the liver, jaundice, having an obstructive character, biliary cirrhosis of the primary type, as well as acute intoxications of various origins;
• erythrocytosis, erythremia, and thromboembolism;
• exacerbation of an ulcer located in the gastrointestinal tract;
• nephrolithiasis, and in addition hypervitaminosis type B.

Side effects of the levasila

The use of medication can cause the appearance of such side effects:

• skin lesions: signs of allergy, including itching, rash, and urticaria;
• digestive disorders: dyspeptic manifestations, abdominal pain, diarrhea, nausea and heartburn, and besides this, the rhythm of feces may change;
• Other: dyspnoea, headaches, potentiation of diuresis or alopecia, and in addition exacerbation of already existing vestibular disorders and the acquisition of urine by a yellow hue.

Overdose

Intoxication can provoke muscle damage - the development of myodystrophy (in connection with the presence of pyridoxine hydrochloride in the composition of LS). Also, diarrhea, vomiting and nausea may appear, and in addition, the severity of side symptoms may increase. Continuous use in large portions can cause polyneuropathy.

To eliminate the violations should be performed gastric lavage, induce vomiting, give the patient activated charcoal and conduct other symptomatic activities that will be needed.

Interactions with other drugs

The combination of silymarin with oral contraception and drugs used during estrogen replacement treatment may cause a weakening of their therapeutic effectiveness.

Medication is able to potentiate the properties of the following drugs: alprosolam and lovastatin with diazepam, and in addition vinblastine with ketoconazole (by suppressing the hemoprotein system P450).

Pyridoxine reduces the effectiveness of levodopa, and in addition eliminates or reduces the toxic symptoms arising from the use of isoniazid and other antituberculous drugs.

Cimetidine, as well as PASK, ethyl alcohol and calcium LS weaken the absorption of cyanocobalamin.

Riboflavin is not compatible with streptomycin, and also weakens the effects of antibacterial drugs (doxycycline and oxytetracycline, as well as lincomycin and erythromycin with tetracycline).

Imimprimin, tricyclics, and amitriptyline slow the metabolic processes of riboflavin, especially inside the cardiac tissues.

[2], [3]

Storage conditions

Levasil is required to be kept in a dry place and closed from children's access. The temperature is a maximum of 25 ° C.

Shelf life

Levasil is allowed to be used for 2 years from the date of manufacture of the therapeutic drug.

Application for children

Due to the lack of existing information, Levasil can not be assigned to children under 12 years of age.

Analogues

Analogues of the medicine are: Milk thistle, Gepar Compositum and Gepa-Merz, and also Glutargin, Phosphogliv and Glutargin Alkoklin, and also Essentiale Forte N and Essentiale.