Levasil

Levasil is a drug with hepatotropic action.

Indications Levasila

It is used in adjuvant therapy of inflammation and toxic lesions affecting the liver: such as chronic hepatitis (including steatohepatitis ), as well as fatty liver disease.

In addition, it is prescribed to prevent the development of liver intoxication (under the influence of alcoholic beverages or medications).

Release form

The drug is released in capsules of 70 mg, in the amount of 10 pieces inside a strip. The box contains 3 such strips.

Also produced in capsules of 140 mg, in the amount of 6 pieces inside a strip. In a pack - 5 such strips.

Pharmacodynamics

Levasil is a drug that improves the functioning of the liver weakened by disease. Its medicinal effect is manifested due to the ability to influence the permeability of the walls of liver cells.

Vitamins that are part of the B-complex and are the constituent elements of the drug are functional components of intermediate metabolic processes. They act as coenzymes in reactions of carbohydrate and protein metabolism, and at the same time have a hepatoprotective effect.

Vitamins increase the rate of restoration of damaged liver parenchyma. In addition, due to hepatopathies, the liver's ability to accumulate vitamins from category B is significantly impaired, resulting in their deficiency in the body.

The use of Levasil, which contains a vitamin complex (B), helps to compensate for the resulting deficiency.

Pharmacokinetics

After oral administration, the main part of the silymarin substance is excreted along with bile, after which it is included in the process of enterohepatic recirculation.

Silibinin is excreted mainly via the kidneys, and the metabolic products (glucuronides and sulfates), which have a bound form, are also found in the bile. Silibinin excretion continues for approximately 24 hours. The majority of the consumed portion (approximately 20-40%) of silibinin is excreted with bile. Only approximately 3-7% of the total portion is excreted via the kidneys.

Dosing and administration

The medicine should be taken after meals. The portion size and duration of therapy are selected by the attending physician individually, taking into account the type of disease and its severity.

The standard serving size is 1 capsule of 70 or 140 mg 2-3 times a day. Later, the serving size can be reduced to 1-2 per day.

The capsules should be swallowed without chewing. The medicine should be washed down with plain water (0.5 glass).

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Use Levasila during pregnancy

There is no information on the safety and therapeutic efficacy of the drug when used during lactation or pregnancy. Therefore, it is prohibited to prescribe it to this group of patients.

Contraindications

Among the contraindications:

• the presence of high sensitivity to the elements of the drug;
• encephalopathy in the liver, jaundice of an obstructive nature, primary biliary cirrhosis, as well as acute intoxications of various origins;
• erythrocytosis, erythremia, and thromboembolism;
• exacerbation of an ulcer located in the gastrointestinal tract;
• nephrolithiasis, and also hypervitaminosis type B.

Side effects Levasila

The use of the drug may cause the following side effects:

• skin lesions: signs of allergy, including itching, rash, and hives;
• digestive disorders: dyspeptic symptoms, abdominal pain, diarrhea, nausea and heartburn, and in addition, the rhythm of bowel movements may change;
• others: dyspnea, headaches, increased diuresis or alopecia, as well as exacerbation of existing vestibular disorders and the acquisition of a yellow tint in the urine.

Overdose

Intoxication can provoke muscle damage - the development of myodystrophy (due to the presence of pyridoxine hydrochloride in the composition of the drug). Diarrhea, vomiting and nausea may also occur, and in addition, the severity of side effects may increase. Long-term use in large portions can cause polyneuropathy.

To eliminate the disorders, it is necessary to perform gastric lavage, induce vomiting, give the patient activated charcoal and carry out other symptomatic measures that will be necessary.

Interactions with other drugs

The combination of silymarin with oral contraception and drugs used during estrogen replacement therapy may cause a weakening of their therapeutic effectiveness.

The drug is able to potentiate the properties of the following drugs: alprazolam and lovastatin with diazepam, as well as vinblastine with ketoconazole (by suppressing the hemoprotein P450 system).

Pyridoxine reduces the effectiveness of levodopa and also eliminates or reduces toxic symptoms that occur due to the use of isoniazid and other anti-tuberculosis drugs.

Cimetidine, as well as PAS, ethyl alcohol and calcium drugs weaken the absorption of cyanocobalamin.

Riboflavin is not compatible with streptomycin and also weakens the effect of antibacterial drugs (doxycycline and oxytetracycline, as well as lincomycin and erythromycin with tetracycline).

Imiprimine, tricyclics, and amitriptyline slow down the metabolic processes of riboflavin, especially within cardiac tissue.

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Storage conditions

Levasil should be stored in a dry place, out of reach of children. Temperature – maximum 25°C.

Shelf life

Levasil can be used for 2 years from the date of manufacture of the therapeutic drug.

Application for children

Due to insufficient existing information, Levasil should not be prescribed to children under 12 years of age.

Analogues

The analogs of the drug are: Milk thistle, Hepar Compositum and Hepa-Merz, as well as Glutargin, Phosphogliv and Glutargin Alcoclin, as well as Essentiale Forte N and Essentiale.