Latren

Latren is a medicine that promotes the improvement of microcirculation processes, and besides this rheological characteristics of blood. 

Indications of the latrena

It is used to eliminate disorders of peripheral blood flow function, diabetic form of neuropathy, syndrome, as well as Raynaud's disease, intermittent claudication, and at the same time with obliterating endarteritis. Use the drug and in disorders of tissue trophism.

The drug is prescribed in combination with other medicines for the treatment of gangrene, varicose veins, postthrombophlebitic syndrome, trophic-type ulcers, and frostbite.

Latren is also used for circulatory disorders in the brain, ischemic stroke, DAP, and in addition to atherosclerosis in the cerebral vessels, against which dizziness develops with headaches, problems with memory and sleep.

At the same time, the medicine is used to eliminate blood flow disorders inside the choroid in the retina and eye area, and besides for the treatment of degenerative changes, in the course of which the hearing is gradually weakened (this is due to vascular disease of the inner ear).

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Release form

The release is carried out in the form of a solution for infusions in flasks with a volume of 100, 200 or 400 ml.

Pharmacodynamics

The active component of drugs is the element pentoxifylline, which is part of the purine category as a peripheral vasodilator. The medicine removes smooth muscle spasms inside the bronchi with blood vessels, as well as other internal organs. It also slows phosphodiesterase and helps increase the number of cyclic 3,5-AMP within smooth muscle vascular cells and platelets. The use of drugs increases the amount of ATP inside the erythrocytes, and at the same time increases the energy cellular potential.

Latren helps to relax smooth vascular muscles and reduce the overall peripheral vascular resistance (without significantly altering the heart rate), and in addition increase the blood volume (systolic and minute).

The drug has antianginal properties due to relaxation of smooth muscles in the coronary arteries.

The medicine helps to saturate the blood with oxygen by expanding the pulmonary vessels and tonifying the respiratory muscles (intercostal muscles and diaphragm), and at the same time it potentiates collateral blood flow and increases the volume of blood flowing to tissues with organs.

Latren has a positive effect on the bioelectric function of the central nervous system and helps to increase the level of ATP inside the cerebral cells.

Influencing the characteristics of the erythrocytic membrane, the drug increases its elasticity. It leads to platelet disaggregation and helps to reduce the viscosity of the blood.

Increased collateral blood flow improves microcirculation within the ischemic areas.

During the treatment of intermittent claudication (defeat in the peripheral arteries of the occlusive type), the substance pentoxifylline increases the walking distance, eliminates cramping at the calf muscles at night and prevents the development of pain in a calm state.

Pharmacokinetics

The drug is almost completely exposed to metabolism, resulting in the formation of 5 degradation products (including pharmacoactive ones).

Excretion of the substance mainly occurs through the kidneys - in the form of decay products. The half-life of pentoxifylline along with its metabolites is about 0.5-1.5 hours. If the patient has liver / kidney problems, lengthening of the half-life is possible.

Dosing and administration

Latren's solution must be administered iv. The size of the dose is determined by the doctor, taking into account the weight of the patient, and in addition, the tolerability of the treatment and severity of circulatory disorders.

Adults and adolescents from 12 years of IV infusion are performed according to the following scheme: 200 ml of the solution is required to be injected intravenously for 90-180 minutes. If a good tolerance of the drug is found, an increase in the dosage is allowed - IV infusion of 400-500 ml of the solution by the jet method.

The therapeutic course on average lasts often about 5-7 days. A more accurate figure depends on the clinical picture. Then the patient can be transferred to the oral form of the drug.

During the day, you can enter no more than 300 mg of the drug substance.

It is also possible to use the solution for therapy in children under 12 years old, as well as newborns. In this case, the dosage is calculated taking into account the weight of the child. Children under 12 years of age are usually prescribed a solution of 10 ml / kg (5 mg of the drug).

Use of the latrena during pregnancy

Use Latren in lactation or pregnancy is prohibited.

Contraindications

Among the contraindications:

• The patient's hypersensitivity to any element of the drug, and in addition to the xanthine derivatives;
• use for treatment of people with porphyria, myocardial infarction in the acute stage, and in addition with hemorrhagic stroke, hemorrhage in the eye retina and atherosclerosis in the field of coronary or cerebral vessels in a severe degree;
• use in people with arrhythmia, liver / kidney failure, uncontrolled reduction in blood pressure and excessive bleeding.

Caution is needed when using people with heart failure, diabetes mellitus and peptic ulcer lesions inside the gastrointestinal tract. In addition, caution is prescribed for the elderly and those who have recently undergone surgery (you need to regularly monitor hematocrit with hemoglobin).

Side effects of the latrena

Use of the solution can cause the following side effects:

• disorders of the NA function: problems with sleep, dizziness, convulsions, headaches and a sense of unreasonable anxiety. Aseptic form of meningitis is observed;
• damage to the hematopoietic system and CCC: skin hyperemia on the face, as well as the upper part of the body, puffiness, arrhythmia with angina and tachycardia, as well as cardialgia, decreased level of blood pressure, thrombocyto-, leuko- and pancytopenia;
• abnormalities of the function of the gastrointestinal tract and hepatobiliary system: the appearance of nausea or vomiting, the development of intestinal atony, hepatitis of the cholestatic type or anorexia, and in addition an increase in the activity of liver enzymes and exacerbation of cholecystitis;
• other: the occurrence of internal bleeding or bruising, deterioration of vision and increased fragility of nails;
• allergy symptoms: development of itching, skin hyperemia, Quincke edema, hives, or anaphylaxis.

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Overdose

As a result of intoxication with pentoxifylline, dizziness, a feeling of drowsiness of weakness or excitement, a decrease in blood pressure level, and a faint may develop. Together with this, if you continue to increase the dose, hyperthermia, tachycardia, areflexia develop, and in addition, the appearance of seizures and bleeding in the gastrointestinal tract and loss of consciousness.

The medicine does not have a special antidote. In case of poisoning, it is necessary to perform procedures aimed at getting rid of signs of an overdose. Such treatment is carried out at the hospital under the constant supervision of doctors.

Interactions with other drugs

Drug exposure of drugs is weakened by smoking.

Latren in combination with thrombolytics or anticoagulants (both direct and indirect) is capable of potentiating their properties. Simultaneous use of these drugs is allowed only if the indicators of blood turnover are regularly monitored.

The combination of the drug with cephalosporins potentiates the effectiveness of their effects.

Pentoxifylline enhances the effect of antihypertensive drugs, valproate, insulin, as well as antidiabetic drugs.

Combined use with cimetidine increases the plasma values of pentoxifylline.

The simultaneous reception of Latren with other drugs that are xanthine derivatives can cause the patient nervous overexcitation.

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Storage conditions

Latren is stored in usual conditions for medicines. The temperature is a maximum of 25 ^° C.

Special instructions

Reviews

Latren is considered a very effective drug, judging by the feedback, it works perfectly for various violations of the CCC function. Very effectively manifests itself as a means to improve blood circulation.

It is often used to treat obliterating endarteritis.

Shelf life

Latren is allowed to be used in the period of 2 years from the date of release of the drug.