A non-recommended combination is alcohol. In particular, the risk of developing lactic acidosis is high during acute alcohol poisoning, which is combined with liver failure, starvation or malnutrition. In the period of treatment, Langerin is required to abandon alcoholic beverages and medicines that contain alcohol.
Contrast medications containing iodine - in case of combination with them, the probability of developing liver failure is likely to increase, which will result in the accumulation of metformin and increase the risk of lactic acidosis.
The use of metformin should be discontinued 48 hours before the examination, and then not renewed for at least 48 hours after the end of the procedure, and begin only after the renal function has been evaluated.
It is necessary to avoid the combination with danazolum in order to prevent the hyperglycemic effect from using the latter. If you refuse to use danazol impossible, you need to adjust the dosages of metformin during the treatment and at the end of it, and also monitor the glycemic parameters.
Hyperglycemic effect has diuretics, SCS with local and systemic effects, as well as β-2-sympathomimetics. It is necessary to warn patients about it, and to evaluate the glycemia as often as possible, especially at the initial stage of using these medicines. During the period of the combined course, and also at its completion, it is necessary to adjust the dose size of Langerin, taking into account the glucose values.
ACE inhibitors can reduce the glycemic index. If necessary, it is necessary to adjust the dosage size of the antidiabetic drug in case of combination with this drug or when it is abolished.
High doses of chlorpromazine (100 mg per day) increase the sugar index, weakening the insulin release. In cases of using neuroleptics, and in addition, after the abolition of these drugs, you need to adjust the dosage of Langerin, controlling the glycemic index.