Lansoprazole, similarly to other inhibitors of the "proton pump," lowers the indices of atazanavir (which is an inhibitor of HIV protease), the absorption of which is associated with the acidity of the stomach. Because of this, Lancerol can affect the effectiveness of atazanavir, and also contribute to the development of HIV-related resistance. Because of this, it is forbidden to combine these medicines.
The drug is able to increase the plasma values of drugs that are metabolized by the CYPZA4 element (such as ibuprofen and prednisolone with warfarin, and in addition antipyrine with phenytoin and indomethacin, propranolol with clarithromycin, and terfenadine with diazepam).
Drugs that depress 2C19 (eg, fluvoxamine) can greatly increase (approximately fourfold) the plasma level of lansoprazole, so if combined with them, the dose of the latter should be adjusted.
Inductors of elements 2S19, as well as CYPZA4 (among such herbs of St. John's wort with rifampicin) are able to greatly reduce the plasma values of lansoprazole, so when combined with them, the dose of Lancerol should be adjusted.
Lansoprazole is able to suppress the secretory function of the stomach for a long time, which can affect the level of bioavailability of drugs, for absorption of which acidity values are important (among them digoxin with ketoconazole, iron salts with itraconazole, as well as ampicillin esters).
Antacids and sucralfate are able to reduce the bioavailability of the drug, and therefore need to use it at least 1 hour after using the above drugs.
Combination of the drug with theophylline (elements CYP1A2, as well as CYPZA) causes a moderate increase (not more than 10%) of the purification coefficient of this substance, but the likelihood that such an interaction will have a medicinal value is very low. It should be noted that individuals need to adjust the dosage of theophylline at the initial stage of the combination therapy and after the completion of the use of Lancerol in order to maintain the drug-effective values of theophylline.
Lansoprazole has no effect on the prothrombin time, as well as the pharmacokinetic properties of warfarin.
Increasing the values of PTV and MNO can cause bleeding, and in the future even provoke a fatal outcome.
Combined reception with digoxin promotes an increase in the plasma values of this substance.
Combined use with tacrolimus increases its plasma level (especially for those who underwent organ transplantation).