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Lamifen
Last reviewed: 23.04.2024
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Indications Lamifen
Indication for the prescription of the drug are: fungal skin lesions, the causative agents of which are trichophyton dermatophytes (for example, trichophyton red or T. Mentagrophytes, or warty trichophyton or T. Violaceum), and in addition, Microsporum canis and flaky epidermophyton (epidermophytia of the feet in the interdigital area , inguinal epidermophytia, ringworm). In addition, it is prescribed for pityriasis, induced Malassezia furfur.
Release form
Available in the form of a gel in tubes with a volume of 15 or 30 g. One package contains 1-tube.
Pharmacodynamics
Terbinafine is an allylamine and has powerful antimycotic properties. If there is a required concentration, terbinafine acquires fungicidal properties, affecting dermatophytes, as well as mold and individual dimorphic fungi. In relation to yeast fungi, the activity of the drug can be fungistatic or fungicidal (this depends on the type of fungus).
At an early stage, the active substance specifically slows the process of biosynthesis of sterols in the fungal plasmalemma. As a result, there is a lack of ergosterol, as well as the accumulation of squalene within the cell, which causes the fungal cells to die. The effect of terbinafine is by suppressing the squalene epoxidase enzyme in a fungal plasmalemma. This enzyme is not part of the P450 hemoprotein system. Terbinafine has no effect on the process of hormonal metabolism or the metabolism of other drugs.
With external use, the drug begins to act fairly quickly - it helps to get the result in a fairly short time (about 1-2 weeks). Absorbed less than 5% of the active substance, so the drug has no significant effect on the systemic blood flow.
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Dosing and administration
The duration of the treatment course depends on the type of disease and the degree of its severity.
It is necessary to treat the skin 1 time per day. Before the procedure, it is necessary to clean and dry the affected areas, and then apply the gel to these places and the areas adjacent to them. The medicine should be rubbed a little. If there are infections in which diaper rash in the skin folds (between the fingers, buttocks, and in the groin and under the mammary glands), you should cover the treated places with gauze, especially at bedtime.
Elderly patients do not need dosage adjustment.
Use Lamifen during pregnancy
Since the information on the use of gel during pregnancy is too small, it is not recommended to use the drug, except when the potential benefit for a woman is higher than the risk of developing negative consequences for the fetus.
Contraindications
Among the contraindications: individual intolerance to terbinafine or another component of the drug.
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Side effects Lamifen
Among the side reactions: burning, itching and desquamation, as well as the appearance of irritation at the treatment site. In addition, the development of erythema, the violation of pigmentation, the formation of the crust. These symptoms should be distinguished from allergic manifestations (such as a rash) - in this case, you need to cancel the treatment. If the medicine accidentally gets into the eye, irritation may develop. Sometimes there is an exacerbation of a latent fungal infection.
Other adverse reactions:
- immune system: hypersensitivity (including hives);
- skin and connective tissue: damage and lesions of the skin, dryness, development of eczema or contact dermatitis;
- Other violations at the treatment site: pain and irritation, as well as exacerbation of manifestations of the disease.
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Overdose
With external use of the drug, an overdose does not occur. The occurrence of adverse effects is possible due to accidental oral administration of the gel. In this case, there may be dizziness, nausea, diarrhea, pain in the epigastrium, as well as neutropenia and thrombocytopenia.
Symptomatic therapy is used to eliminate overdose symptoms.
Storage conditions
Keep the medicine in a place that is not accessible to children. Temperature conditions - no more than 25 ° С. The drug should not be frozen.
Shelf life
Lamifen is allowed to be used for 2 years from the date of manufacture of the medicine.
Attention!
To simplify the perception of information, this instruction for use of the drug "Lamifen" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.