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Khumulin
Last reviewed: 23.04.2024
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Humulin has hypoglycemic activity. An insulin agent is a DNA recombinant substance, suspension for injection of 2-stage nature, which has a therapeutic effect of medium duration.
The insulin effect of the medication may have personal differences in different patients. These differences depend on the area of application of the medicinal substance, the selection of a suitable dosage portion, the physical activity of the patient, the dietary regimen observed and some other factors.
Release form
The release is made in the form of a suspension used for the use of subcutaneous injections - inside the vials with a capacity of 10 ml (1 piece) or cartridges with a volume of 1.5 or 3 ml (5 pieces) used in the syringe pens.
Pharmacodynamics
Humulin mainly acts by regulating the metabolic processes of glucose, and with it has an anabolic effect. Inside muscle and other tissues (excluding cerebral), insulin promotes the activation of the intracellular movement of glucose with amino acids, and in addition increases the rate of protein anabolism.
The drug helps the intrahepatic conversion of glucose into a component of glycogen, slows down the process of gluconeogenesis and contributes to the transformation of excess sugar into fats.
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Dosing and administration
Humulin can not be administered intravenously.
When using insulin, the mode of use and dosage portions are determined only by the doctor - personally, taking into account the glycemic indicators. The drug is injected subcutaneously, but sometimes intramuscular injections can be used.
Subcutaneous injections are performed in the thighs, buttocks, abdomen or shoulders area. In one area the drug is administered a maximum of 1-fold per month, alternating injection sites. During the procedure, it is necessary to use the devices for injection correctly, to prevent the needle from penetrating into the vessels and not to press on the injection area after the injection.
To prepare an insulin dose for subcutaneous injection, it takes a dozen times to roll the bottle or medicine cartridge in the palm of your hand and shake the container a little until the suspension acquires a turbid homogeneous consistency similar to the appearance of milk.
You can not shake the container too sharply, because such an action can cause the formation of foam, which complicates the exact set of the required dosage.
It is forbidden to introduce and suspension, which contains after mixing the precipitate or flakes.
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Use Khumulin during pregnancy
In pregnant women with diabetes, it is extremely important to monitor the dynamics of glycemia. During this period, insulin demand often varies greatly (decreases on the 1st trimester and increases on the 2nd and 3rd), which may require a change in dosages.
Changing the size of portions, physical activity and diet regime may be required during lactation.
Side effects Khumulin
During the performance of insulin therapy, hypoglycemia is often observed, which can, in severe cases, cause hypoglycemic coma (suppression and loss of consciousness), and sometimes even death.
It is also possible the development of local signs of allergy in the form of swelling, itching or redness in the injection area (such violations usually disappear after a few days or weeks). At times, these symptoms may not be associated with insulin, but arise due to the influence of external factors or improper use of drugs.
In addition, the occurrence of common allergic manifestations, which develop more rarely, but are more pronounced, is noted. In such cases, there may be generalized itching, breathing problems, increased heart rate, hyperhidrosis, dyspnea, and a decrease in blood pressure.
With extremely severe disorders, allergies can even threaten the patient's life, requiring urgent medical treatment. Insulin replacement or desensitization may be required.
Lipodystrophy, resistance and hypersensitivity to insulin mainly develops when using its animal form.
Overdose
With the development of hypoglycemia, vomiting, trembling, pallor of the epidermis, tachycardia, lethargy, hyperhidrosis, confusion and headaches are noted.
In the mild stage of the development of the disease, it can be prevented by taking oral glucose or sugar. In addition, you may need to change the portion of insulin and change the scheme of physical activity or diet regime.
In the moderate form of hypoglycemia, glucagon is often intramuscularly or subcutaneously injected, and then the patient needs to take carbohydrates orally.
In severe hypoglycemia, against which there are convulsions, neurological disorders, as well as a coma, an intramuscular or subcutaneous injection of glucagon or intravenous administration of glucose concentrate is required.
Further, in order to prevent the recurrence of hypoglycemia, the patient should eat a lot of carbohydrates. In hypoglycemic conditions of a very severe nature, it is necessary to urgently hospitalize the patient.
Interactions with other drugs
Ethyl alcohol, MAOI, hypoglycemic drugs taken orally, an ACE inhibitor (captopril with enalapril), sulfonamides with salicylates, non-selective β-adrenergic blockers and substances that block the activity of angiotensin-2 endings, potentiate the therapeutic effect of Humulin.
The hormones thyroid and STG, GCS, danazol, OK, diuretic substances of thiazide character and β2-sympathomimetics (among them ritodrin with salbutamol and terbutaline) weaken the hypoglycemic activity of insulin.
Octreotide with lancreotide and other somatostatin analogues are able to reduce or increase insulin dependence.
Reserpine with clonidine and β-blockers are able to hide the manifestations of hypoglycemia.
Storage conditions
Humulin should be stored in a dark place at temperatures of 2-8 ° C (in the refrigerator), while not freezing the solution.
Used insulin can be stored at a temperature of 15-25 ° C within a 4-week term.
Shelf life
Humulin can be used for a 3-year period from the date of sale of the drug substance.
Analogs
Analogues of the medication are the drugs Monodar, Humalog Mix and Reizodeg Flekstach with Novomix 30 Flekspen.
Reviews
Humulin receives positive reviews from diabetics, but only in situations where the substance is fully suitable for the patient. In such cases, it demonstrates an effective therapeutic effect and almost does not lead to the appearance of negative symptoms.
Attention!
To simplify the perception of information, this instruction for use of the drug "Khumulin" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.