Inwance

Invanz is an antibacterial drug with a systemic effect. It is a β-lactam antibiotic, which includes the category of carbapenems.

[1], [2], [3], [4]

Indications of the invenza

It is used to eliminate infectious lesions caused by strains of bacteria that have increased sensitivity to the drug:

• infections inside the abdomen, in a complicated form;
• non-hospital pneumonia;
• acute forms of infections of the gynecological type;
• infections that affect the skin and subcutaneous layers (in a complicated form), including foot diseases that result from diabetes (such as diabetic foot syndrome);
• infectious diseases of the urinary system in a complicated form (this includes pyelonephritis);
• bacterial septicemia.

In addition, it is used as a preventive drug that helps to prevent the emergence of infections that develop after elective surgical operations of the colorectal type.

Release form

Release in the form of powder for the injection solution, inside the bottles with a volume of 20 ml. The package contains 1 or 5 of these bottles.

Pharmacodynamics

The basis of the bactericidal effect of drugs is the slowing down of the binding of the cell walls. This effect is mediated by the ability of the drug to be synthesized with penicillin-binding proteins.

The substance ertapenem possesses resistance to the processes of hydrolysis with the help of β-lactamases of the main subclasses, which include penicillinases with cephalosporinases. High activity demonstrates the strains of aerobes and anaerobes of the optional species (Gram-negative, as well as Gram-positive bacteria): pneumococci with streptococci pyogenic and agalactia, as well as Staphylococcus aureus. In addition, it also acts on intestinal rods with hemophilic rods, on clostridia and bacteroidia fragilis, on prevotella with peptostreptococcus, eubacteria and Asaccharolytica Porphyromonas.

A number of microbes that have multi-resistance to different antibiotics (such as penicillins with cephalosporins, as well as aminoglycosides) are highly sensitive to Inwance.

Pharmacokinetics

The drug is rapidly absorbed from the site of the intravenous injection. When a dose of 1 g is given, the peak is observed on average after 2.5 hours.

The drug is also subjected to active protein synthesis. The bioavailability level reaches about 92%. There is no cumulation of the substance after administration of the solution in medicinal dosages. Metabolism of the drug occurs inside the liver.

Excretion is carried out by the kidneys, and also, in small amounts, with feces. The average half-life time is approximately 4 hours.

Dosing and administration

The drug can be injected in / m or intravenously. Before the injection, skin tests are required to determine the patient's sensitivity to the drug.

Elimination of infections.

The standard dosage size of drugs for adolescents from 13 years and adults is a once-a-day introduction of IV in the method of the 1st g solution.

For children aged 3 months and up to 12 years, the dosage usually is 15 mg / kg 2 times a day (it is forbidden to administer more than 1 g solution per day) by intravenous infusion.

With intravenous infusion, Invenza is required to be administered for half an hour. Intramuscular injections are sometimes used as an alternative way of using the drug.

Often, treatment with a solution lasts for 3-14 days, and a more accurate figure depends on the severity of the disease and its type, as well as on the type of bacterium pathogen. When there are medicinal indications (there is an improvement in the condition), it is allowed to switch to the appropriate antimicrobial treatment with oral medicines.

In the prevention of the development of infectious lesions due to surgery: 1 g of solution is required to be injected once intravenously, 60 minutes before the surgical procedure.

Before performing the injection, it is necessary to dissolve the lyophilizate, and then dilute it. To prepare an intravenous infusion, you need to use a 0.9% solution of sodium chloride or sterile water. During the manufacture of the injection solution for intravenous infusion, it should not be mixed with other drugs, but in addition use solvents containing glucose.

Preparing the intramuscular solution requires the use of lidocaine hydrochloride as a solvent.

Injection in / m occurs deep inside the muscles of the buttock or in the region of the lateral femoral muscles. Do not use solutions for intramuscular injection for IV administration.

Long-term therapy with the use of Inwance can cause the growth of bacteria that have resistance to the drug.

[5]

Use of the invenza during pregnancy

Appropriate and well-controlled tests for the use of In-venza were not carried out by pregnant women. Animal tests do not show a direct or indirect adverse effect on the fetus, its development, delivery, and postnatal development. But still pregnant women are recommended to take the medicine only in cases when the probable benefit exceeds the risks of complications for the fetus.

Ertapenem passes into the mother's milk. Since infants, whose mothers use the drug, may develop negative reactions, they are required to refuse breastfeeding for the duration of treatment.

Contraindications

Among the contraindications: previously diagnosed hypersensitivity to the elements of the drug or other drugs from the same category and to β-lactam drugs (cephalosporins or penicillins). Since there is no information on the use of the solution in infants until 3 months, it is forbidden to assign it to this age group.

Lidocaine hydrochloride (a drug-solubilizer drug) can not be used by people who suffer from intolerance with regard to local amide anesthetics, as well as to persons with cardiac blockade or a shock condition in severe form.

Side effects of the invenza

Among the side effects caused by the drug: allergy symptoms, vomiting, headaches, diarrhea with nausea, and in addition dizziness, fatigue or weakness, as well as insomnia or a feeling of drowsiness. Thrombophlebitis of the postinfusion type may develop, candidiasis in the mouth or thrush, convulsions appear, dry mouth of the mouth, abdominal pain, belching, blood pressure decreases, skin itching or rash occurs, and flavors also occur. There may be puffiness, a state of fever, colitis, thrombocyto- or leukopenia, as well as erythrocyturia.

Interactions with other drugs

During the combined use of ertapenem with drug-blockers of tubular secretion, no changes in dose sizes are required.

Combined medication with valproate or sodium divalpro proteom decreases valproic acid levels, which increases the likelihood of an attack of seizures.

There is no reliable information on the interaction of the drug with other drugs, except for the drug Probenecid.

[6], [7]

Storage conditions

Sealed vials of powder should be kept in a temperature not exceeding 25 ° C. It is forbidden to freeze solutions of Inwan.

Special instructions

Reviews

In vance has for the most part positive feedback from patients. The drug demonstrates effectiveness in the process of eliminating a variety of pathologies of inflammatory-infectious origin.

Among the shortcomings of the drug is a fairly high price for it.

Shelf life

Invalz is allowed to be used in the period of 2 years from the date of release of the drug. Ready injection solution for intramuscular injection can be stored for a maximum of 1 hour.