As a result of the combination of the drug with ACE inhibitors and β-adrenergic blockers, the hypotensive properties of the latter decrease.
Combined use with hypothiazide, furosemide and other diuretic drugs weakens their pharmacological properties.
Ibuprofen increases the properties of anticoagulants, so in the case of simultaneous use of these drugs increases the likelihood of bleeding in the gastrointestinal tract.
In case of use together with SCS, the likelihood of developing negative reactions from the digestive tract may increase.
The active component of the drug displaces from the process of synthesis with plasma protein the following drugs (when combined with them): anticoagulants of indirect action, antidiabetic drugs (oral), hydantoin derivatives and sulfonylureas.
Combined use with hydrochlorothiazide, amlodipine and captopril slightly weakens their hypotensive properties.
The combination with ibuprofen increases the toxic effect of methotrexate, as well as baclofen.
Aspirin reduces the plasma indices of ibuprofen.
Simultaneous use with the substance warfarin increases the duration of bleeding, and with it the development of hematomas and microhematuria.
Combination with colestyramin weakens the absorption of the active substance inside the digestive tract.
Combined reception with lithium drugs provokes an increase in lithium indices in plasma. Along with this, the drug, when used concomitantly, increases the concentration of digoxin with phenytoin inside the plasma.
Magnesium hydroxide enhances the initial absorption of ibuprofen inside the gastrointestinal tract.