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Ikzim is an antimicrobial drug for oral use.





J01DD08 Cefixime

Indications of ikzyme

Indicated for the elimination of infections provoked by pathogenic flora, which is sensitive to the effects of substances cefixime:

  • acute or chronic forms of lung diseases;
  • acute or chronic stages of diseases of upper respiratory tract;
  • bacterial infection in the kidneys or urinary ducts;
  • in acute forms of intestinal infections.

Release form

Produced in powder form in 50 ml vials. Inside the package contains 1 bottle, in a set with a measuring cup attached.


The medicine belongs to the category of third generation cephalosporins, which have a pronounced bactericidal activity, as well as strong resistance to the action of β-lactamases.

Actively acts on gram-negative and also gram-positive bacteria: pneumococci, streptococcus pyogenes, E. Coli, proteus mirabilis, klebsiella, hemophilic rod (gram-positive with gram-negative β-lactamase), moraxel cataralis (gram-negative with gram-positive β-lactamase), and enterobacter. Most enterococci, and in addition to pseudomonads, bacteroid fragilis, listeria monocytogenes, as well as staphylococci and clostridia, are insensitive to the effects of cefixime.

Increased sensitivity to the drug also have salmonella intestinal, salmonella enteric and vulgar prothey.


The medicine is quickly absorbed from the digestive tract. At internal use the peak of its indicators in the blood comes in 2-6 hours. The bioavailability level reaches 30-50%. Synthesis with albumins is 65%. The half-life lasts 2.5-4 hours. Elimination of the substance is carried out with urine, often in unmodified form. About 10% of LS is excreted with bile.

Use of ikzyme during pregnancy

Ikzim can not be given to pregnant women, but also during lactation.


Among the contraindications: a strong intolerance to the substance cephalosporin, and along with this penicillin or other components of drugs. In addition, the presence of bleeding inside the gastrointestinal tract, porphyria, liver failure and nonspecific type of ulcerative colitis.

Side effects of ikzyme

Use of drugs can provoke specific side effects:

  • hematopoietic and lymphatic processes: development granulotsito-, trombotsito-, neutropenia and leukopenia, and in addition, eosinophilia or hypereosinophilic. The emergence of thrombocytosis, agranulocytosis, hypoprothrombinemia, hemolytic forms of anemia, thrombosis, purpura. Additionally can increase the duration of prothrombin and thrombin time (appearance bruising bleeding without visible reasons);
  • organs of the digestive system: stomach cramps, diarrhea, abdominal pain, nausea, dyspepsia. In addition, vomiting, flatulence, candidiasis oral mucosal overgrowth, glossitis or stomatitis;
  • bile ducts and the liver: the development of cholestasis, jaundice, hepatitis and in addition;
  • Infectious diseases: pseudomembranous colitis form;
  • Laboratory tests: an increase in AST or ALT levels, urea and bilirubin in the blood, and in addition, serum creatinine;
  • the process of metabolism: loss of appetite with the development of anorexia;
  • NA organs: dizziness, headaches, hyperactivity condition, the development of dysphoria;
  • auditory organs: hearing loss;
  • respiratory system organs, sternum and mediastinal disorders: dyspnea development;
  • kidney and urinary system: the acute stage renal failure with interstitial nephritis as an underlying disease, but in addition, the development of hematuria;
  • subcutaneous fat with the skin and the immune system: anaphylaxis, symptoms similar to serum sickness, and besides medication rash accompanied by systemic symptoms, and eosinophilia. In addition, the swelling of the face, a state of fever, itching and rash, arthralgia, and fever medication form. May develop angioedema or urticaria. The above symptoms generally disappear after drug withdrawal. It is also possible the development of toxic epidermal necrolysis or Stevens-Johnson;
  • mammary glands and reproductive system: candidiasis or vaginitis, and itching in the genital area;
  • Other disorders: severe fatigue, sweating, a feeling of weakness, inflammation of the mucous membranes.

Dosing and administration

Ikzim is an antibiotic for internal use, used to treat children (age 0.5-12 years with a weight less than 50 kg), the dosage is 8 mg / kg 1 time per day or 4 mg / kg twice a day .

At the age of more than 12 years with weight more than 50 kg it is required to drink 400 mg once or 200 mg twice a day. The average therapeutic course is 10-14 days.

With a chronic form of kidney failure (the glomerular filtration rate is> 20 ml / minute), half the daily dosage is required. In other cases, the size of the dose should not be adjusted.

To make a suspension, you must first shake the vial of powder to make it fluff. Then, boiled water is added to the vessel, cooled to room temperature (at level 1 of the label) and shaken. After that, add water to the upper mark and mix until a suspension is formed. You need to drink it 5 minutes after the powder has dissolved. It is recommended to shake the medicine before each use.


Due to an overdose of the drug, functional disorders may occur in the liver or kidney, and in addition nausea along with vomiting, hallucinations, as well as dizziness and hyperreflexia.

There is no specific therapy for disorders. To remove symptoms, you need to perform gastric lavage, take deintoxication drugs and sorbents. Procedures for peritoneal dialysis and hemodialysis will not work.

Interactions with other drugs

In the case of combination with probenecid, the pharmacological properties of Ikzyme are enhanced.

When taken with salicylic acid in large doses, the bioavailability of cefixime can be increased by 50%.

The active component of the drug increases the peak value of carbamazepine, which increases the likelihood of an overdose from it.

Nifedipine increases bioavailability of cefixime, and in addition increases the likelihood of side effects.

Aminoglycosides, as well as furosemide, increase the nephrotoxic properties of cefixime. False positive glucose reactions in the urine can develop in the case of simultaneous use of cefixime with copper sulfates, felting fluid or Benedict's reagent.

Cefixime can provoke false-positive reactions with a direct Coombs test.

Combined use with warfarin and anticoagulants prolongs prothrombin time. This should be taken into account when prescribing the medicine to people who are treated with anticoagulants.

The effectiveness of combined oral contraception is weakened when combined with Ikzyme.

Storage conditions

The medicine should be kept in a place that is closed from moisture and sun, as well as access to small children. The temperature is a maximum of 25 ° C.

Shelf life

Ikzyme usable life for 2 years from the date of its release. The finished slurry may be stored up to 2 weeks (in a dark and dry place).

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To simplify the perception of information, this instruction for use of the drug "Ikzyme" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.

Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.

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