In the case of combination with probenecid, the pharmacological properties of Ikzyme are enhanced.
When taken with salicylic acid in large doses, the bioavailability of cefixime can be increased by 50%.
The active component of the drug increases the peak value of carbamazepine, which increases the likelihood of an overdose from it.
Nifedipine increases bioavailability of cefixime, and in addition increases the likelihood of side effects.
Aminoglycosides, as well as furosemide, increase the nephrotoxic properties of cefixime. False positive glucose reactions in the urine can develop in the case of simultaneous use of cefixime with copper sulfates, felting fluid or Benedict's reagent.
Cefixime can provoke false-positive reactions with a direct Coombs test.
Combined use with warfarin and anticoagulants prolongs prothrombin time. This should be taken into account when prescribing the medicine to people who are treated with anticoagulants.
The effectiveness of combined oral contraception is weakened when combined with Ikzyme.