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Chondrosamine
Last reviewed: 04.07.2025
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Chondrosamine contains chondroitin with glucosamine. It is included in the category of antirheumatic drugs and NSAIDs.
Indications Chondrosamine
It is used for combination therapy for diseases in the musculoskeletal system, as well as other disorders, against the background of which changes in the condition of cartilaginous tissue in the joints are observed, having a degenerative-dystrophic form:
- osteoarthritis of primary or secondary type (1-3 degrees), periodontopathy and osteoporosis;
- periarthritis of the shoulder-scapular nature, spondylosis with osteochondrosis, as well as chondromalacia in the patellar region;
- various fractures (to speed up the process of bone callus formation);
- pathologies in the spine and joints that have a degenerative-dystrophic nature.
Release form
The drug is released in capsules, in the amount of 10 pieces inside a blister pack. The box contains 6 such packs.
Pharmacodynamics
The therapeutic effect of the drug is provided by the activity of the components that are part of its composition - glucosamine hydrochloride, as well as chondroitin sulfate.
Chondroitin
Chondroitin is a high-molecular-weight mucopolysaccharide (20,000-30,000 g/mL), located in many different types of connective tissues, especially within cartilage (it is an auxiliary substrate in the formation of the cartilage matrix).
This element affects the processes of phosphorus-calcium metabolism inside cartilage tissues. In addition, it slows down resorption in the area of bone tissues and reduces calcium loss, and also increases the rate of bone tissue regeneration and slows down the degeneration of cartilage tissues. It also stimulates the healing of cartilage in the area of joints, helps to restore the joint capsule and cartilage surfaces in the area of joints.
At the same time, the substance maintains the viscous structure of the synovium, prevents compression of connective tissues and acts as a lubricating element inside the joints.
Chondroitin slows down the progression of osteoarthritis complications and reduces the severity of its manifestations, reduces the need for NSAIDs and stabilizes metabolic processes within the hyaline tissue. In addition, it helps form hyaluronic acid, bind type 2 collagen and proteoglycans, and prevents the breakdown of hyaluronic acid under the action of enzymes (including lysosomal enzymes), which results in the destruction of connective tissues.
Glucosamine
Glucosamine is an endogenous element contained in glycosaminoglycans and proteoglycans. It promotes the activation of the binding processes of hyaluronan, proteoglycans, chondroitin sulfuric acid, and other components that act as a material from which the joint membranes, cartilaginous tissues, and fluid located in the joints are formed. The element also potentiates the production of cartilaginous matrix and stabilizes the processes of calcium deposition inside bone tissues.
In addition, the substance non-specifically protects cartilage from chemical damage, including effects caused by the action of GCS and NSAIDs. It has a moderate anti-inflammatory effect. Systematic use helps slow down the progression of degenerative processes inside the spine with joints, as well as perispinal soft tissues.
The medication is a participant in biosynthesis processes in the area of connective tissues, prevents the destruction of cartilage and promotes the healing of its tissues.
The interaction of the active elements of the drug ensures the development of anti-inflammatory, healing and analgesic effects, thereby improving joint mobility. Continuous use of the drug reduces the need for NSAIDs, which has a positive effect on the patient's health.
A stable therapeutic effect is observed after 6 months of taking the drug.
Pharmacokinetics
After oral administration, 90% of the drug is absorbed through the gastrointestinal tract. Peak values in the blood plasma are noted after 3-4 hours, and in the synovium - after 4-5 hours.
The level of bioavailability in relation to synovia is 13% for chondroitin and 25% for glucosamine (due to the pronounced effect of the first liver pass).
After distribution within tissues, the highest LS values are observed within articular cartilage and kidneys with liver. About 30% of the consumed portion remains within muscle and bone tissues for a long time.
The half-life is approximately 6-8 hours. Most of the unchanged substance is excreted in the urine, with some excreted in the feces.
Dosing and administration
The medicine is taken orally, washed down with plain water.
It is necessary to take 2 capsules 2-4 times a day. After 30 days of such therapy, it is allowed to reduce the dose to 2 capsules with 1-2 times a day. The therapeutic effect develops slowly and can persist for a long time after the end of taking the drug.
The minimum permissible duration of the treatment cycle is 1.5 months. The peak therapeutic effect is observed after 2-3 months of taking the drug.
Use Chondrosamine during pregnancy
There are no adequate controlled tests of medicinal efficacy and safety when used in pregnant or lactating women.
Contraindications
Main contraindications:
- the presence of intolerance to medicinal components;
- thrombophlebitis;
- severe renal dysfunction;
- tendency to bleeding;
- phenylketonuria.
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Side effects Chondrosamine
The use of the drug may cause some side effects: for example, dizziness or skin allergies. Gastrointestinal disorders are also possible - abdominal pain, constipation, nausea and diarrhea with bloating.
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Interactions with other drugs
Combined use with chloramphenicol or penicillins increases the absorption of tetracyclines within the gastrointestinal tract.
Chondrosamine can be combined with GCS and NSAIDs. It should also be noted that when taking it, the need for NSAIDs is reduced.
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Storage conditions
Chondrosamine should be kept in a dark and dry place, out of reach of small children. The temperature level should be within 15-25°C.
Shelf life
Chondrosamine can be used within 24 months from the date of release of the therapeutic drug.
Attention!
To simplify the perception of information, this instruction for use of the drug "Chondrosamine" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.