Holudexan

Choludexan is a medication with a hepatoprotective effect.

Indications Holudexana

It is used for therapy in the following cases:

• chronic form of active hepatitis;
• cholelithiasis;
• liver damage caused by the action of toxins (for example, due to drug poisoning);
• alcoholic form of liver pathology;
• liver cirrhosis (primary or biliary);
• dyskinesia;
• cholangitis or steatohepatitis;
• atresia in the biliary tract (may also be congenital);
• cystic fibrosis;
• esophagitis or reflux gastritis.

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Release form

The substance is released in capsules. 10 pieces are placed in blister packs. There are 2 such packs inside the box.

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Pharmacodynamics

Because the medicine has hepatoprotective properties, it can have a choleretic effect, and at the same time helps to form and subsequently dissolve stones inside the body. In addition, the medicine has a hypolipidemic, immunomodulatory, and at the same time hypocholesterolemic effect.

Due to the presence of the UDCA element in the composition of the drug, non-toxic forms of mixed-type micelles are formed together with apolar bile acids. As a result, the negative effect of gastric reflux on cell membranes (develops with esophagitis or reflux gastritis) is leveled.

The effect of the UDCA component leads to the formation of molecules inside the human body that are embedded in the cell walls of hepatocytes with cholangiocytes, as well as epithelial cells inside the stomach. This leads to their stabilization and the development of resistance to pathogenic cytotoxic micelles. UDCA reduces the level of bile acids, which have a destructive effect on liver cells, and also stimulates the process of choleresis, characterized by the presence of a large number of bicarbonates.

The highly active binder contained in the preparation helps to reduce the cholesterol values in bile, resulting in a decrease in its gastric absorption and binding in the liver. UDCA also interacts with cholesterol and increases its solubility in bile, which ultimately leads to the formation of crystals and a decrease in the lithogenic index. The result is the complete dissolution of gallstones.

Laboratory test results have shown that the drug has a high ability to block fibrosis in people with cirrhosis, cystic fibrosis or alcoholic steatohepatitis. At the same time, Choludexan prevents the development of varicose veins inside the esophagus and slows down the processes of premature aging, as well as the death of hepatocytes with cholangiocytes and other cells.

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Dosing and administration

The drug must be used in accordance with the treatment regimens presented below:

• a cycle lasting a minimum of 10-14 days/maximum of 0.5-2 years, and including daily intake of 1 capsule of the drug (0.3 g) before bedtime (treatment of esophagitis or reflux gastritis);
• a continuous cycle lasting a minimum of several months/maximum of 2 years, includes the use of 2-5 capsules/day (treatment of chronic liver pathologies, cholelithiasis, biliary sludge and cholesterol gallstones). The medicine should be taken until the stones are completely dissolved, and then for another 3 months to prevent the appearance of neoplasms;
• in a course lasting at least 6 months, take the medicine in a daily dose of 10-15 mg/kg (for the treatment of biliary cirrhosis);
• in the period of 0.5-2 years, use Choludexan in a daily dose of 13-15 mg/kg (for steatohepatitis that is not associated with alcoholic beverages);
• a cycle consisting of several months and including taking 2 capsules of the drug per day (prevention of the development of cholecystectomy or cholelithiasis);
• during a cycle lasting 0.5-1 year, it is necessary to take 10-15 mg/kg of the drug per day (therapy for liver diseases caused by the action of drugs or toxins, as well as for atresia);
• during the period of 0.5-2 years, it is necessary to take a daily dose of 20-30 mg/kg (treatment of cystic fibrosis);
• for a course lasting 0.5-2 years, it is required to take 12-15 mg per day (maximum - 20 mg) - for the treatment of cholangitis.

For therapy in children over 4 years of age, the drug is prescribed in a daily dose of 10-20 mg/kg.

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Use Holudexana during pregnancy

It is usually not recommended to use Choludexan during pregnancy, but if there are vital indications, it can be prescribed by the attending physician, but only if he is sure that the possible benefit from taking it is more likely than the risk of negative symptoms.

In addition, it is forbidden to use capsules during breastfeeding.

Contraindications

Among the contraindications:

• gallbladder dysfunction;
• the presence of gallstones of a radio-positive nature (if they contain a large volume of the element Ca);
• acute cholecystitis;
• fistulas arising in the bile-gastric region;
• cholangitis in the acute stage;
• infections that affect the gallbladder with bile ducts, as well as the intestines (acute phase of the disease);
• cirrhosis at the stage of decompensation;
• liver or kidney failure;
• empyema affecting the gallbladder;
• the presence of high sensitivity to drug components.

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Side effects Holudexana

Taking the medicine may cause some side effects: nausea, pain in the back, exacerbation of psoriasis, vomiting, alopecia, constipation or diarrhea, as well as a transient increase in the activity of liver transaminases.

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Interactions with other drugs

The absorption of Choludexane is weakened when combined with antacid drugs (colestyramine, ion exchange resins, and aluminum).

Hypolipidemic drugs reduce the intensity of stone dissolution (this effect is most clearly manifested when combined with clofibrate, neomycin, progestin and estrogen).

The drug potentiates the antidiabetic activity of corresponding drugs taken orally.

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Storage conditions

Choludexan should be kept in a place inaccessible to children. Temperature level – within 15-20°C.

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Shelf life

Choludexan is allowed to be used within 36 months from the date of manufacture of the therapeutic agent.

Application for children

The medicine can be used by children aged 4 years and older, in the portions indicated below in the instructions.

Analogues

Analogues of the drug are Urso, Livodex, Ursosan with Ursodez, Ursolit, Ursoliv with Ursor Rompharm, as well as Urdoksa, Ursofalk, Ursodeoxycholic acid, Ursorom S and Ursodex, and also Exhol.

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Reviews

Choludexan receives various reviews regarding its medicinal effectiveness. There are people who noted the positive effect of the drug, but there are also comments from those who were disappointed with the drug. In this case, most likely, the effectiveness of the drug depends on the individual characteristics of each individual patient.