Holudeksan

Choludexan is a medicament with a hepatoprotective effect.

Indications Choludexane

It is used for therapy in such cases:

• chronic form of active hepatitis;
• cholelithiasis ;
• hepatic lesions, provoked by the action of toxins (for example, when poisoning with medicines);
• alcoholic form of hepatic pathology;
• hepatic cirrhosis (primary or biliary nature);
• dyskinesia;
• Cholangitis or steatohepatitis;
• atresia in the biliary tract (may also be congenital);
• cystic fibrosis;
• esophagitis or reflux gastritis.

[1]

Release form

The substance is released in capsules. 10 pieces are placed in blister packs. Inside the box there are 2 such packages.

[2]

Pharmacodynamics

Because the medicine has hepatoprotective properties, it can have a cholagogic effect, and with it helps to form and further dissolve stones inside the body. In addition, the drug has lipid-lowering, immunomodulating, and at the same time hypocholesterolemic effect.

Due to the presence of an element of UDCA in the drug, non-toxic forms of mixed-type micelles are formed together with bile acids of an apolar nature. As a result, the negative effect of gastric reflux on cell membranes (developing with esophagitis or reflux gastritis) is leveled.

The influence of UDCA component leads to the formation of molecules inside the human body that are embedded in the cell walls of hepatocytes with cholangiocytes, as well as epithelial cells inside the stomach. This leads to their stabilization and development of immunity against pathogenic cytotoxic micelles. UDCA reduces the level of bile acids, which have a destructive effect on the liver cells, and also stimulates the process of choleresis, which is distinguished by the presence of a large number of bicarbonates.

Highly active binder, which is contained in the drug, helps to reduce the cholesterol inside the bile, resulting in a decrease in its gastric absorption and binding within the liver. UDCA also interacts with cholesterol and increases its solubility in the bile, which eventually leads to the formation of crystals and a decrease in the level of the lithogenic index. A consequence of this is the complete dissolution of the gallstones.

The testimony of laboratory tests revealed that the drug has a high ability to block fibrosis in people with cirrhosis, cystic fibrosis or steatohepatitis of an alcoholic nature. Along with this, Holudexan interferes with the development of varicose veins inside the esophagus and inhibits the processes of premature aging, and in addition the death of hepatocytes with cholangiocytes and other cells.

[3], [4]

Dosing and administration

The drug should be used in accordance with the following treatment regimens:

• cycle, lasting at least 10-14 days / maximum 0.5-2 years, and including the daily intake of the 1st capsule LS (0.3 g) before bedtime (treatment of esophagitis or reflux gastritis);
• a continuous cycle lasting at least a few months / a maximum of 2 years, includes the use of 2-5 capsules / day (treatment of hepatic pathologies in the chronic stage, cholelithiasis, biliary sludge and biliary cholesterol stones). Take the medicine should be until the full dissolution of the stones, and then for another 3 months to prevent the appearance of tumors;
• a course of at least 6 months, use the drug in a daily dose of 10-15 mg / kg (for treatment with biliary cirrhosis);
• in the period of 0.5-2 years, use Holudexan in a daily dose of 13-15 mg / kg (with steatohepatitis, which is not associated with alcohol);
• a cycle consisting of several months, and including the taking of 2 capsules of medicines per day (preventing the development of cholecystectomy or cholelithiasis);
• during the cycle lasting 0.5-1 year, it is required to consume 10-15 mg / kg of medication per day (therapy for hepatic diseases, provoked by the action of drugs or toxins, and besides with atresia);
• in the period of 0.5-2 years it is required to take a daily dose of 20-30 mg / kg (treatment of cystic fibrosis);
• a course of 0.5-2 years, takes 12-15 mg per day (maximum 20 mg) for the treatment of cholangitis.

For therapy in children older than 4 years of age, the drug is prescribed in a daily dose of 10-20 mg / kg.

[12]

Use Choludexane during pregnancy

Use Holudexan during pregnancy is usually not recommended, but in the presence of life testimony it can appoint a doctor, but only if he is sure that the possible benefits of his admission is more likely than the risk of negative symptoms.

In addition, it is forbidden to use capsules during the period of breastfeeding.

Contraindications

Among the contraindications:

• disruption of the gallbladder;
• presence of biliary calculi of X-ray positive nature (if they contain a large volume of element Ca);
• acute form of cholecystitis;
• fistulas arising in the bile-gastric region;
• Cholangitis at the stage of exacerbation;
• infections that affect the gallbladder with bile ducts, as well as the intestines (acute phase of the disease);
• cirrhosis at the stage of decompensation;
• insufficiency of liver or kidney function;
• empyema affecting the gallbladder;
• The presence of high sensitivity for the components of drugs.

[5], [6], [7], [8]

Side effects Choludexane

Taking medication can cause some side effects: nausea, pain on the back, exacerbation of psoriasis, vomiting, alopecia, constipation or diarrhea, as well as a transient increase in hepatic transaminase activity.

[9], [10], [11]

Interactions with other drugs

Absorption of choludexan is weakened when combined with antacids (colestyramine, ion exchange resins, and aluminum).

Lipid-lowering drugs weaken the intensity of dissolution of stones (this effect is most evident when combined with clofibrate, neomycin, progestin and estrogen).

The drug potentiates the antidiabetic activity of the corresponding medicines consumed orally.

[13],

Storage conditions

Holudexan must be kept in a place that is closed from children's access. The temperature level is within the limits of 15-20 ° C.

[14]

Shelf life

Choludexan is allowed to be applied within 36 months from the date of manufacture of the therapeutic agent.

Application for children

You can use the medicine for children, whose age reaches 4 years, in the portions indicated in the instructions below.

Analogues

Analogues of the drug are drugs Urso, Livedoksa, Ursosan with Ursodez, Ursolit, Ursoliv with Ursoron Rompharm, as well as Urdoksa, Ursofalk, Ursodeoxycholic acid, Ursor C and Ursodex, and Exxhol.

[15], [16], [17], [18], [19],

Reviews

Holudexan receives a variety of reviews regarding drug effectiveness. There are people who noted the positive impact of drugs, but there are also comments from those who were disappointed with the medicine. In this case, most likely, the effectiveness of the drug depends on the individual characteristics of each individual patient.