Hepasol neo 8%

Gepasol Neo 8% is an infusion fluid used for parenteral nutrition procedures; It contains a complex of various amino acids.

Amino acids during metabolic processes synthesize ammonium ions, which have a powerful toxic effect, and also help them to remove. The drug significantly potentiates liver detoxification activity, and also prevents ammonia damage of tissues inside the CNS and PNS in people with disorders of the liver work.

Indications Hepasola neo 8%

The substance is used to provide the body with amino acids by parenteral administration. It is prescribed in case of insufficiency of the liver of a severe nature (accompanied by encephalopathy or not), when enteral or oral nutrition is prohibited, not enough or impossible.

Release form

The release of the drug substance is produced in the form of an infusion fluid, inside 0.5 l bottles.

Pharmacokinetics

The level of bioavailability of all amino acids contained in the fluid is 100%.

When used parenterally, the introduced amino acids are distributed, as well as undergo metabolic processes within all body tissues; they are participants of protein binding, as well as the processes of providing the body with energy. Those amino acids that have not been used by the cells undergo deamination with the formation of urea.

Excretion is carried out through the kidneys in the form of metabolic elements. In the case of parenteral administration at high speed, some of the amino acids are excreted unchanged.

Dosing and administration

You can use the medicine exclusively at the hospital and only for adults.

The drug should be administered intravenously - in the region of the central and peripheral veins. Servings used - 1.0-1.25 ml / kg per hour, which equals 0.08-0.1 g / kg of amino acids per 1 hour. The speed of the infusion can be no more than 1.25 ml / kg in 60 minutes, which corresponds to 0.1 g / kg of amino acids in 60 minutes. A maximum of 1.5 g / kg of amino acids per day is allowed, which corresponds to 18.75 ml / kg and is equivalent to 1.3 liters for a person with an average weight of 70 kg.

In the case of parenteral nutrition, the substance is usually administered in combination with liquids satisfying the energy requirement (fat emulsions with carbohydrates), and in addition, the need for vitamins, electrolytes and trace elements.

The duration of drug use is determined by the clinical picture. The drug should be used until the metabolic processes of amino acids are stabilized.

Use Hepasola neo 8% during pregnancy

Testing regarding the safety of using Gepasol Neo 8% during pregnancy or breastfeeding was not performed. Clinical data do not contain information with a proven risk of adverse effects during the specified periods. In the case of the appointment of the drug in these terms, it is necessary to carefully evaluate the benefits and risks of its use.

Contraindications

The main contraindications:

• severe intolerance associated with elements of the drug;
• disorder of amino acid metabolism;
• hyperhidria;
• hypokalaemia or -treatremia;
• kidney failure;
• CH in decompensated stage;
• hypoxia or shock;
• metabolic acidosis;
• pulmonary edema in the active phase.

Side effects Hepasola neo 8%

In the case of drug administration inside the peripheral veins, thrombophlebitis can develop.

With the right use of the medication, side effects usually do not develop.

In the case of the use of funds that contain amino acids, sometimes there are headaches, symptoms of severe sensitivity and manifestations in the area of the injection.

Overdose

With proper use of Gepasol NEO 8% the likelihood of developing poisoning is extremely low. If the infusion is too rapid in the region of peripheral veins, thrombophlebitis may appear (it is necessary to select an appropriate osmolarity). Individuals with previously induced disorders of the liver activity may develop vomiting, proteinuria, nausea, and fever.

If symptoms of intoxication develop, it is necessary to immediately stop the infusion.

Interactions with other drugs

Amino acid liquid cannot be mixed with other solutions (except substances for parenteral feeding), because there is a possibility of incompatibility or microbiological mixing.

Combination with other parenterally administered nutritional components is allowed upon confirmation of their compatibility.

Storage conditions

Gepasol Neo 8% is required to be kept in a dark place closed from small children. Temperature indicators - not more than 30 ° С.

Shelf life

Hepasol Neo 8% can be used within a 2-year term from the date of manufacture of the drug.

Application for children

It is forbidden to use the medicine in pediatrics.

Analogs

Analogues of drugs are the substances Aminoven Infant 10%, Nefrotect with Aminoplasmal 10% E, as well as Aminosteril-H-Hepa.