Heparil

Heparil has an intense anticoagulant and antithrombotic effect, demonstrates anti-edema activity, reduces inflammation and helps heal connective tissue.

The anticoagulant effect develops with a direct effect on the blood-clotting system, by forming a compound with antithrombin-3, which synthesizes intraplasma coagulation factors. The substance stimulates metabolism, tissue epithelialization and granulation. The intensity of the drug effect of the gel significantly exceeds the effect exerted by the ointments - because the gel can penetrate deeper into the tissues.

[1]

Indications Heparilа

It is used for diseases affecting superficial veins - for example, varicose veins (and its complications), thrombophlebitis with phlebothrombosis, and also periphlebitis of a superficial nature.

It can be used for postoperative phlebitis of varicose nature and complications associated with surgical removal of the saphenous veins in the legs.

Appointed in the case of localized swelling, infiltrates, injuries with bruises, as well as subcutaneous hematomas. Together with these, it is used in case of sprains or injuries affecting the capsule-ligament and muscle-tendon structures.

[2], [3]

Release form

The release of the drug component is realized in the form of a gel, inside a tube with a capacity of 40 g. There is 1 tube in a box.

Pharmacokinetics

Heparin is determined inside the blood plasma for 24 hours from the time the medicine is used; Heparin Cmax values are noted after 8 hours. After external treatment, the gel does not cause the development of systemic effects.

After absorption of the substance, it passes through the intrahepatic and reticuloendothelial biotransformation. Intlasma protein synthesis equals 95%.

The term half-life is 1-1.5 hours. Excretion is realized through the kidneys.

Dosing and administration

The medicine is used 1-3 times a day. The affected area is treated with gel (3-10 cm), gently rubbing it. The duration of therapy is chosen individually (this is done by the attending doctor), taking into account the degree of intensity of the pathology.

The applied substance is completely absorbed through the epidermis after 1.5-2 minutes, leaving no stains behind.

[12]

Use Heparilа during pregnancy

There is no information regarding the use of the drug during lactation or pregnancy, so it is not prescribed during these periods.

[4], [5], [6]

Contraindications

Among the contraindications:

• severe intolerance to heparin or other elements of the drug, including parabens (nipazol with nipagin);
• having a bleeding nature trophic type ulcers on the legs;
• infected with infection or open wounds;
• hemophilia;
• hemorrhagic diathesis;
• thrombocytopenia or purpura;
• tendency to bleed.

[7], [8], [9]

Side effects Heparilа

Occasionally, manifestations of intolerance can be noted, including epidermal itching and swelling, burning, redness, urticaria, hemorrhages, rashes and angioedema. In addition, small bubbles, pustules or bubbles may appear (they quickly disappear after stopping the use of drugs). Treatment of large areas of the epidermis can cause common adverse events.

[10], [11]

Overdose

If the gel is swallowed by a small child, vomiting or nausea may occur.

If this happens, gastric lavage is required and symptomatic measures should be taken if necessary. The effect of heparin is neutralized with protamine sulfate.

[13], [14]

Interactions with other drugs

Heparin contributes to the prolongation of PTV parameters in people who use anticoagulants for oral administration.

It is forbidden to combine Heparil with other local medicines (for example, substances that contain salicylic acid, tetracycline or hydrocortisone) and anticoagulants.

[15], [16]

Storage conditions

Heparil must be kept in a closed place from the penetration of young children. Temperature indicators - a maximum of 25 ° C.

[17]

Shelf life

Heparil can be used for a 36-month term from the date of manufacture of the therapeutic agent.

Application for children

Because the experience of using drugs in pediatrics is extremely limited, it is not used in children.

Analogs

Analogues of the drug are the substances Venitane, Heparoid, Lyogel, Venohepanol with Esfatil, Liotromb, Venosan with Hepatrombin, and in addition, Viatrombe, Dermaton, Heparin ointment, Lioton and Thrombocide with Thromblosis.