Glycine

Glycine is a simple amino acid compound that is one of the main building blocks of protein in the human body. It is part of protein molecules and is involved in many biological processes.

Glycine can also be used in medicine as a drug. It is often used as a supplement to foods, vitamin supplements, and medications to improve sleep and the nervous system, as well as reduce stress and anxiety. It can also be used to treat certain conditions, such as insomnia, neuroses, as well as to improve memory and cognitive functions.

Indications Glycine

1. Improving sleep and reducing insomnia.
2. Stress and anxiety.
3. Neuroses and nervous disorders.
4. Increasing cognitive functions and improving memory.
5. Heart and nervous system support.
6. Improved concentration and resistance to stress.

Release form

Glycine is usually available in tablet or capsule form for oral administration. The dosage may vary depending on the manufacturer and the specific brand of the drug.

Pharmacodynamics

1. Neurotransmitter action: Glycine is one of the main inhibitory neurotransmitters in the central nervous system. It acts as an inhibitory neurotransmitter, suppressing the excitation of nerve cells and helping to reduce the activity of the nervous system. This makes it an important regulator of the balance of excitation and inhibition in the brain.
2. Participation in protein synthesis: Glycine plays an important role in protein synthesis, which is necessary for growth, tissue repair and maintenance of normal cell function.
3. Activation of glycine receptors: Glycine also acts directly on glycine receptors, increasing their activity and reducing the excitability of nerve cells. This helps improve the function of inhibitory transmission systems in the brain.
4. Participation in metabolism: Glycine is involved in the metabolism of amino acids and other important metabolic processes in the body.
5. Anticonvulsant: Glycine has the ability to reduce nervous system excitability, making it potentially useful in the treatment of some forms of seizures.
6. Involvement in signaling in peripheral tissues: Glycine also plays a role in signaling between nerve and muscle cells, which may be important for the control of muscle tone and contraction.

Pharmacokinetics

Glycine is a simple amino acid preparation that is generally well absorbed by the body when taken orally. It is rapidly absorbed through the gastrointestinal wall and distributed rapidly throughout the body. Glycine is metabolized in the liver and is involved in various biochemical processes, such as protein and neurotransmitter synthesis. Excess glycine that is not used in the body is excreted mainly through the kidneys as urea.

Dosing and administration

Glycine is usually taken in the form of tablets or capsules for oral administration. Here are general recommendations for dosage and method of application:

• To relieve stress and improve sleep, it is usually recommended to take 1-2 tablets (or capsules) of glycine in the afternoon or evening, half an hour before bedtime. You can also take one tablet throughout the day as needed.
• To improve cognitive function and maintain memory, the dosage can be increased to 3-4 tablets per day, divided into several doses.
• Glycine tablets can usually be dissolved in the mouth or taken with water. For better absorption, it is recommended to keep the tablet under the tongue until completely dissolved.

Use Glycine during pregnancy

Glycine is generally considered relatively safe during pregnancy. However, it is important to consult with your doctor before taking any medication, including glycine, to ensure it is safe for you and your baby.

Contraindications

1. Allergies: People with a known allergy to glycine or other amino acids may have an allergic reaction to glycine. Therefore, before using it, you should make sure that there are no allergic reactions.
2. Pathological Aminopathy: In people with disorders of amino acid metabolism (for example, those with pathological aminopathy), the use of glycine may require caution and medical supervision.
3. Diabetes mellitus: Glycine may affect blood glucose levels, so patients with diabetes mellitus should be careful when using it and perhaps consult a doctor.
4. Pregnancy and breastfeeding: Information on the safety of glycine during pregnancy and breastfeeding is limited, so its use requires consultation with a doctor.
5. Renal Impairment: Glycine may cause effects on the kidneys and its use may be contraindicated or require dosage adjustment in patients with renal impairment.
6. Liver Impairment: Similar to renal impairment, glycine may have effects on the liver and its use may be contraindicated or require dosage adjustment in patients with hepatic impairment.

Side effects Glycine

1. Allergic reactions such as skin rash, itching or swelling of the face and throat are rare.
2. Nausea, vomiting, or stomach discomfort may occur in some people, especially if recommended doses are exceeded.
3. In some cases, headache or drowsiness may occur, especially when first starting to take the drug or with an increased dosage.

Overdose

1. Hyperglycinia: When large doses of glycine are consumed, an increase in glycine levels in the blood may occur, which can lead to hyperglycinia. This may be accompanied by various symptoms such as dizziness, fatigue, confusion, muscle weakness and even severe cases of coma and seizures.
2. Lowering Blood Pressure: Glycine may have a slight lowering effect on blood pressure. If consumed in excess, it can lead to hypotension, especially in people with already low blood pressure.
3. Metabolic imbalance: It is possible that excessive glycine intake may disrupt the body's metabolic balance, although this usually occurs with underlying medical conditions or other risk factors.
4. Gastrointestinal Irritation: In rare cases, excess glycine may cause gastrointestinal irritation or dysfunction, which may include diarrhea, nausea, or vomiting.
5. Drug Interactions: Excessive glycine intake may interact with certain medications, especially medications used to treat seizures or mental disorders.

Interactions with other drugs

Glycine usually does not exhibit significant interactions with other drugs.