Gynoforte

Gynofort is a drug whose main active ingredient is butoconazole. Butoconazole belongs to the class of antifungal drugs and is commonly used to treat fungal infections in gynecology.

The drug is used in the form of a cream or vaginal tablets and can be recommended for the treatment of various fungal infections of the female genital organs, such as vaginal candidiasis (cracks and irritations around the vagina caused by yeast-like fungi Candida albicans), vaginal trophic candidiasis, bacterial vaginosis, coccogoryosis and others.

Butoconazole works by killing fungal cells or inhibiting their growth and reproduction, which leads to the disappearance of the infection. When used correctly, Gynofort can help eliminate the symptoms of a fungal infection and speed up recovery. However, before using Gynofort, it is important to consult a doctor for a proper diagnosis and recommendations for use.

Indications Gynoforte

1. Vaginal candidiasis (thrush): This is the most common use of Gynofort. Vaginal candidiasis is caused by a yeast-like fungus called Candida albicans and presents with a variety of symptoms including itching, burning, irritation in the vaginal area, and a profuse white, loose discharge.
2. Atrophic vaginitis: This is a condition in which the vaginal mucosa becomes thinner and more sensitive due to decreased estrogen, which can lead to the development of a yeast infection.
3. Bacterial vaginosis: Although butoconazole is primarily used to treat yeast infections, in some cases it may also be recommended to treat bacterial vaginosis, although this is a less common use.

Release form

Gynofort, which contains butoconazole, is usually available as vaginal creams or suppositories. These forms allow the drug to be applied directly inside the vagina to treat various vaginal infections, such as vaginal candidiasis (cracks or infections caused by yeast-like fungi).

Pharmacodynamics

Butoconazole belongs to the class of antimycotic (antifungal) drugs, it has a broad spectrum of activity against various fungal infections, including yeast-like fungi (eg, Candida spp.) and dermatophytes (fungi that cause dermatomycosis).

It acts by inhibiting the synthesis of ergosterol, an important component of the fungal cell membrane. This leads to disruption of the cell membrane function, fungal growth, reproduction and, ultimately, death.

Pharmacokinetics

1. Absorption: Butoconazole is usually administered vaginally as a cream or suppository. Following vaginal administration, it can be absorbed through the vaginal mucosa and resorbed into the systemic circulation. Absorption is usually low, and most of the butoconazole remains at the injection site, providing local action.
2. Metabolism: Butoconazole is metabolized in the liver. It undergoes metabolic changes that result in the formation of metabolites, which can then be excreted from the body.
3. Excretion: Butoconazole and its metabolites are generally excreted from the body via the kidneys and bile.
4. Half-life: The half-life of butoconazole in the body may vary depending on the individual characteristics of the patient and the conditions of use of the drug.
5. Drug Interactions: Because butoconazole is administered topically, systemic interactions with other drugs are generally low. However, it is important to consider potential interactions, especially if the patient is taking systemic antifungal drugs or drugs that may affect liver or kidney function.

Dosing and administration

1. Directions for use:

   • Before using Ginofort, it is recommended to wash your hands thoroughly.
   • If the medication is in cream form, it should be applied inside the vagina using the applicator provided in the package. This is usually done while lying on your back or with your legs slightly bent.
   • If the medication comes in suppository (vaginal tablet) form, it should be inserted into the vagina as deeply as possible using the provided applicator or finger.

2. Dosage:

   • The dosage of Ginofort may vary depending on the severity of the infection and the doctor's recommendations.
   • It is generally recommended to use one dose of cream or suppository daily, usually for 1 to 2 weeks.
   • The dosage may be adjusted by the doctor depending on the individual characteristics of the patient and the severity of the disease.

Use Gynoforte during pregnancy

The use of Gynofort (butoconazole) during pregnancy is generally considered safe for the treatment of vaginal candidiasis, especially in the second and third trimesters, when the risk to the fetus is minimized due to topical application and limited absorption. However, as with any medication, its use should be discussed with a doctor.

1. One study showed that miconazole, which is similar in action to butoconazole, is effective and safe in the treatment of vaginal candidiasis during pregnancy, demonstrating high therapeutic and mycological cure rates in pregnant women (Weisberg, 1987).
2. Updated data on the use of antifungals during pregnancy indicate that topical antifungals, including butoconazole, are used because of their limited absorption, which reduces the risk of exposure to the fetus (Pilmis et al., 2015).

It is important to consult a doctor before starting treatment with Gynofort during pregnancy to ensure the safety and effectiveness of therapy taking into account individual circumstances.

Contraindications

1. Hypersensitivity or allergic reaction: People with known hypersensitivity to butoconazole or other components of the drug should avoid using it.
2. Pregnancy and breastfeeding: Pregnant and breastfeeding women should consult their doctor before using Gynofort to weigh the benefits of treatment against the potential risks to the baby.
3. Children: The efficacy and safety of Gynofort in children have not been established, therefore its use in children may be undesirable.
4. Systemic fungal infections: Gynofort is intended for topical use and is not suitable for the treatment of systemic fungal infections. If a systemic infection is present, you should consult a doctor for appropriate treatment.
5. Damage to the skin or mucous membranes: The use of Ginofort may be contraindicated in the presence of significant damage to the skin or mucous membranes at the site of application.

Side effects Gynoforte

1. Burning, itching or irritation in the vaginal area: Some women may experience a temporary increase in symptoms such as itching, burning or irritation in the vaginal area. This may be caused by a reaction to the drug itself or a reaction to a yeast infection.
2. Change in color or odor of vaginal discharge: There may be a change in vaginal imbalance, which may cause a change in color or odor of the discharge.
3. Skin reactions: Some people may experience a skin reaction such as a skin rash, redness, or swelling at the application area.
4. Allergic reactions: In rare cases, serious allergic reactions such as hives, swelling of the face, difficulty breathing, and anaphylactic shock may occur. If signs of an allergic reaction occur, seek immediate medical attention.
5. Other rare side effects: Other side effects may include headache, nausea, lower abdominal pain, or diarrhea.

Overdose

Information on overdose of Gynofort (containing butoconazole) is limited, as overdose cases are rare or absent. However, if overdose is possible, you should contact your doctor or medical institution for advice and treatment.

Since Ginofort is applied topically in the form of a cream or suppository, the probability of overdose is low. However, if the drug is swallowed or used in the wrong dose, unwanted effects may occur.

Symptoms of a possible overdose may include increased side effects of the drug, such as irritation, burning, itching, or allergic reactions. If any unpleasant symptoms occur after using Ginofort, it is recommended to stop using the drug and seek medical help.

Interactions with other drugs

1. Other antifungal drugs: When used in combination with other antifungal drugs of local or systemic action, an enhanced or competitive effect may occur, which may improve or worsen the effectiveness of treatment.
2. Metal-containing drugs: Since butoconazole is an azole antifungal drug, it may interact with metal-containing drugs such as aluminum, magnesium, calcium and iron, which may reduce its effectiveness. It is recommended to avoid the simultaneous use of Gynofort with such drugs or take them with an interval of time.
3. Medicines that affect vaginal pH: Using medicines or products that change vaginal pH, such as soaps or douches, may change the effectiveness of butoconazole. It is recommended to consult a doctor before using such products during treatment with Gynofort.
4. Hormonal agents: The effectiveness of butoconazole may be slightly affected by the use of hormonal agents such as contraceptives or hormone replacement therapy. However, the effect on practical use is usually minor.

Storage conditions

1. Temperature: It is generally recommended to store Ginofort at a temperature of 15°C to 30°C. This means that the drug should be protected from extreme temperatures, as well as from direct exposure to sunlight and heat sources.
2. Humidity: The product should be stored in a dry place to avoid damage. High humidity may cause deterioration of the product.
3. Packaging: It is important to store Ginofort in the original packaging or in the container it was purchased in. This will help prevent accidental exposure of the drug to light and moisture.
4. Child safety: The drug should be kept out of reach of children to avoid accidental use.