Finlepsin

Finlepsin is an anticonvulsant medication. This is a derivative of dibenzazepine, which has antipsychotic, anti-depressive, analgesic and antidiuretic effects.

The therapeutic efficacy of the drug develops in the case of combined as well as simple epileptic seizures, against which generalization of a secondary nature can be noted, and so on. When using drugs, there is a weakening of signs of depression, aggressiveness, anxiety and irritability.

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Indications Finlepsin

Used for such disorders:

• neuralgia;
• different types of epilepsy ;
• nerve disorders associated with diabetic pain;
• alcohol withdrawal;
• various forms of convulsive disorders - seizures, cramps, etc.;
• psychotic disorders.

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Release form

The release of the drug is implemented in the form of tablets - 10 pieces inside the cell plate. In the box - 3, 4 or 5 such records.

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Pharmacodynamics

Under the influence of the drug, a blockade of the activity of voltage-dependent Na-channels occurs, which helps stabilize the walls of overly excited neurons, reduces the conduction of impulses through synapses, and slows down serial neural discharges.

There is also a reduction in the amount of glutamate released by the body (neurotransmitter amino acid), which demonstrates a stimulating effect, which helps the drug to reduce the convulsive threshold of NA, which as a result reduces the risk of developing an attack of epilepsy.

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Pharmacokinetics

The drug has a low absorption rate, but it is full; however, the degree of absorption is not tied to food intake. The necessary level of medication inside the body is noted for 12 hours, and its therapeutic effect lasts for 4-5 hours.

The medicine reaches equilibrium values inside the plasma after 7-14 days of therapy. But these indicators can vary due to the peculiarities of the patient's metabolic processes: autoinduction of intrahepatic enzyme systems, heteroinduction of others used in combination, drugs, portion size, patient's condition and duration of the course. It is determined that carbamazepine overcomes the placenta and is excreted in breast milk.

Drug metabolism processes are realized inside the liver with the formation of the main metabolic components: carbamazepine-10,11-epoxide, which has a pronounced activity, as well as a conjugate having no activity and glucuronic acid. In metabolic processes, a metabolic element with activity, 9-hydroxymethyl-10-carbamoyl acridane, is formed that can induce its own metabolism.

Excretion is mainly carried out with urine; some of it is excreted with faeces.

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Dosing and administration

The drug is prescribed for oral administration, without reference to food intake.

During epilepsy, Finlepsin is used as monotherapy. In cases where it is attached to anti-epileptic treatment, this is done gradually, with strict monitoring of dosages. When you skip a pill, you need to take it immediately after it was remembered (but taking the 2nd dosage is prohibited).

First, the medication is consumed in portions of 0.2-0.4 g per day. Thereafter, a gradual increase in the batch can be performed in order to obtain an optimal result. The size of the maintenance dosage per day is equal to 0.8-1.2 g (this dosage is divided into 1-3 doses). For the day, you can enter no more than 1600-2000 mg of drug substance.

The selection of the dosage for the child is determined by his age. At the same time, if he cannot swallow the pill whole, it is allowed to grind, chew or dissolve in a small amount of water.

For the age of 1-5 years, use a portion of 0.1-0.2 g, with its gradual increase to obtain the optimal effect.

Persons of 6-10 years old need a daily dosage of 0.2 g, and in the future it is also gradually increased.

A child of 11-15 years old should first take 0.1-0.3 g of the drug. Next, the portion is gradually increased by 0.1 g to develop the desired therapeutic effect.

The size of the average maintenance dosages per day:

• 1-5 years of age - 0.2-0.4 g;
• 6-10 years old - in the range of 0.4-0.6 g;
• 11-15 years of age - 0.6-1 g (divided into several uses).

The duration of the treatment cycle is directly determined by the patient’s personal characteristics and medical indications. In all situations, the treatment doctor should decide on the treatment regimen. Often, the option of reducing the portion or cancellation of the medication starts to be considered when the patient does not have seizures during a 2-3-year period.

With the abolition of therapy should be performed a gradual reduction of the dosage, which lasts 1-2 years; at the same time you need to constantly monitor EEG indicators. A child must also take into account increasing age and weight.

In the treatment of other disorders, the size of the portion and the duration of the drug administration are selected by the doctor, taking into account the patient’s personal characteristics and the severity of the disease.

Use Finlepsin during pregnancy

The use of carbamazepine in pregnant women with epilepsy is required as carefully as possible. When tested on animals, administration of the drug inside led to defects.

In cases when a woman who takes carbamazepine becomes pregnant (either planning to conceive or having already got pregnant, the need for using drugs has arisen), you need to carefully evaluate the likely benefits of the substance and compare it with the possible consequences (most of all it relates to the 1st trimester).

Women who are suitable for conception are advised to use carbamazepine in monotherapy whenever possible.

You need to enter the minimum giving the result portions of drugs and monitor plasma indicators of carbamazepine.

Women need to report an increase in the likelihood of congenital abnormalities and prenatal screenings for them.

Effective anticonvulsant treatment should not be interrupted during pregnancy, since with the exacerbation of the pathology, there may be a threat to both the patient and the fetus.

During pregnancy, a woman may be deficient in B9-vitamin. Anticonvulsants can potentiate this deficiency, which is why it is necessary to additionally assign this element to receive in the specified period.

To prevent blood coagulation disorders in newborns, women (during the last weeks of gestation) and newborn babies should use K1-vitamin.

There is information regarding the occurrence of seizures or suppression of respiration in newborn babies, and also about diarrhea, vomiting, or weak appetite, the cause of which may be precisely carbamazepine.

Carbamazepine is secreted along with milk for HB (equal to 25-60% of plasma drug levels). It is necessary to carefully evaluate the benefits and possible consequences of the use of drugs for HB. Breastfeeding in parallel with the intake of carbamazepine is allowed only on condition that the infant is monitored for the possible occurrence of adverse symptoms (for example, allergic epidermal manifestations or increased sleepiness).

Contraindications

The main contraindications:

• strong sensitivity to the elements of the drug or tricyclics;
• disorders of hematopoietic processes within the bone marrow;
• intermittent porphyria in the active phase;
• AV blockade;
• combination with MAOI or lithium substances.

It is used with great caution in people with CHF of decompensated nature, disorders of the renal / hepatic function, dilutional hyponatremia, suppression of hematopoiesis in the marrow area, prostate hyperplasia, alcoholism in the active phase and increased IOP values, and besides with the use of other drugs and in elderly people.

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Side effects Finlepsin

Often, side effects when administering a drug appear in connection with the excess of a portion or a significant variation in the indices of the active component inside the body.

Mainly observed violations associated with the function of the national Assembly: ataxia, headaches, systemic weakness, dizziness, drowsiness, and so on.

There may be signs of allergy, including erythroderma, urticaria, epidermal rash, and so on.

Among hematopoietic disorders: eosinophilia, lymphadenopathy, platelet or leukopenia, and leukocytosis.

There is a risk of developing problems in the gastrointestinal tract: xerostomia, vomiting, constipation, nausea, diarrhea, and an increase in the action of intrahepatic transaminases and GGT.

There may be lesions affecting metabolic processes and endocrine function: water retention, vomiting, edema, weight gain, hyponatremia, and so on.

There is a possibility of violations in the urogenital system, the cardiovascular system, the ODE, as well as the senses.

Overdose

Finlepsin poisoning leads to the development of various symptoms associated with disorders of the CAS, NA, and in addition the sensory organs, respiratory system and systemic deviations. This causes disorientation, hallucinations, suppression of the central nervous system, visual blurring, agitation, coma and drowsiness. In addition, fainting, tachycardia, pulmonary edema, impaired blood pressure, nausea, breathing problems, urinary retention, vomiting, and so on.

It was revealed that the medicine does not have an antidote, therefore supporting actions are performed, depending on the developed manifestations. With complex violations of the patient is sent to the hospital.

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Interactions with other drugs

The combination of drugs and substances that slow down the effect of CYP3A4 leads to an increase in the plasma level of carbamazepine and the appearance of negative signs. Use together with inducers of CYP3A4 activity usually increases the rate of metabolic processes of carbamazepine, reducing its performance and drug effects.

Introducing lithuania for kids ) can significantly increase the performance of carbamazepine.

A similar effect is observed when using isoniazid, grapefruit juice, loratadine with terfenadine, agents that slow down the action of the virus protease, and propoxyphene. In such cases, you need to change the serving size and monitor the plasma values of the drug.

Mutual increase or decrease in therapeutic indicators is observed when combined with felbamate.

To decrease carbamazepine levels may result in theophylline valpromid and phenobarbital with clonazepam, and in addition, primidone, cisplatin, oxcarbazepine, valproic acid, metsuksimid, doxorubicin together with phenytoin, and besides rifampicin with fensuksimidom and some herbal drugs, which is composed of Common St. John's Wort.

The drug lowers the plasma values of alprazolam, haloperidol, cyclosporine with clobazam, tetracycline, primidone with clonazepam, valproic acid with ethosuximide, and intravenous drugs that contain progesterone with estrogen.

It is determined that tetracyclines reduce the therapeutic activity of carbamazepine.

Introduction in combination with paracetamol increases the likelihood of developing toxic effects on the liver, while at the same time weakening the medicinal effect.

Combining with pimozide, haloperidol, maprotiline, phenothiazines, and tricyclics, as well as clozapine, thioxanthenes, and molindone, potentiates the inhibitory effect on NS, reducing the influence of Finlepsin.

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Storage conditions

Finlepsin is required to keep in the reach of small children, penetration of moisture and sunlight.

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Shelf life

Finlepsin is allowed to apply within a 36-month term from the date of the release of the therapeutic substance.

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Application for children

Children may require increased amounts of medication (because they have eliminated carbamazepine more quickly). It is allowed to appoint Finlepsin in pediatrics since 5 years.

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Analogs

Analogues of drugs are Carbamazepine, Zagretol, Aktinerval, Stazepin with Carbalepsin Retard, and besides this, Apo-Carbamazepine, Storilat, Mazepin with Septol, Tegretol, and so on.

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Reviews

Finlepsin receives rather contradictory reviews from people who accept or accept it. There are comments from people with epilepsy who say that the drug negatively affects mental abilities, causes communication disorders in society and apathy; but at the same time they confirm that its therapeutic efficacy is very high - the drug helps to eliminate epileptic seizures.

There are also reviews about the use of the drug in panic attacks due to being in closed or open spaces. Therapy often eliminates panic, but there are also comments about the fact that it is not possible to get rid of instability in gait.

In general, Finlepsin is still considered one of the most popular anticonvulsants, which effectively acts in the treatment of these indications of violations. Doctors say that it is this drug that acts most efficiently - it is only necessary to adhere to all medical instructions regarding the dose of drugs and other conditions.

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