Finasterid

Finasteride demonstrates antiandrogenic drug activity. It is a hormone-type medicament - it is an artificial selective blocker of the activity of type 2 5α-reductase.

The drug with high efficacy reduces tissue and free dihydrotestosterone levels. At the same time, the drug does not demonstrate tropism with respect to androgenic endings, and at the same time it does not have any other hormonal effect on the body.

[1]

Indications Finasteride

It is used for the following violations:

• prostate hyperplasia, which has a benign form (to reduce its size);
• with the need to improve the processes of urination, as well as to reduce the symptoms of existing hyperplasia;
• the need to reduce the risk of acute urinary retention, which requires catheterization or surgery.

[2],

Release form

The release of the drug element is implemented in tablets - 7, 10 or 14 pieces inside the cell bundle. Inside the box 1, 2, 3 or 4 such packs.

Pharmacodynamics

The 5α-reductase component (type 2) is an intracellular enzyme that converts testosterone to the androgenic substance dihydrotestosterone, which exhibits a higher therapeutic activity.

In the case of prostate adenoma, an increase in its size is directly determined by the conversion of testosterone to the element dihydrotestosterone inside the tissues of the prostate gland.

[3], [4],

Pharmacokinetics

The drug is fully and at high speed absorbed inside the intestine. The suction process ends after approximately 7 hours. The average bioavailability is 80%. Cmax values inside the circulating blood are recorded after 1-2 hours.

93% of drug molecules bind to plasma protein. The drug overcomes the BBB in the case of use for 7-10 days. Intrahepatic metabolic processes lead to the formation of 5 metabolic elements, of which only two have activity.

The term half-life is about 6 hours. About 39% of the applied portion is excreted together with urine in the form of derivatives, and the remainder is excreted.

[5], [6], [7]

Dosing and administration

Finasteride should be taken orally - 1 tablet per 1 time per day (you do not need to chew it). Therapy is often long-term, and the terms are selected for patients personally.

[13], [14], [15], [16], [17]

Use Finasteride during pregnancy

The drug is not prescribed to women.

[8], [9]

Contraindications

Among the contraindications:

• severe drug intolerance;
• prostate carcinoma;
• uropathy, having an obstructive nature.

[10], [11]

Side effects Finasteride

Main adverse events:

• immune disorders: signs of hypersensitivity;
• mental disorders: decreased libido;
• problems with circulatory function: the development of palpitation;
• lesions associated with digestive activity: activation of the action of intrahepatic enzymes;
• epidermal disturbances: itching, rash or urticaria;
• symptoms associated with sexual function and mammary glands: gynecomastia, impotence, pain in the area of the testicles, ejaculation disorder, and a decrease in the volume of ejaculate secreted.

[12]

Overdose

The combination with Ca channel blockers, benzodiazepines, ACE inhibitors, NSAIDs, and in addition with nitrates, H2-terminal blockers, β-blockers, diuretics, quinolones, blockers of the substance HMG-CoA-reductase, and also α-blockers does not lead to the appearance of therapeutic interaction.

[18], [19]

Storage conditions

Finasteride must be kept in a closed place from the penetration of sunlight, moisture and children.

Shelf life

Finasteride can be used within a 3-year period from the time the drug is manufactured.

[20], [21], [22]

Application for children

Finasteride is not used in pediatrics.

[23]

Analogs

Analogues of the medication are the drugs Urofin, Penister, Finister and Finasteride Teva with Adenosteride Health, and in addition Proscar, Avodart, Urofin and Finpros with Prostan.

[24], [25], [26], [27], [28]

Reviews

Finasteride receives good reviews from patients - with long-term use according to the schemes selected by the doctor, the drug demonstrates high therapeutic efficacy.

[29], [30], [31]