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Last reviewed: 11.04.2020

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A combined drug that increases the resistance of brain cells to oxygen starvation, dilates and strengthens the blood vessels of the brain, which activates the influx of arterial blood to the ischemic area. Stimulates cognitive functions, intelligence, as well as the activity of the central departments of the auditory and visual analyzer.

trusted-source[1], [2], [3]

Indications of the fezama

Presence of foci of ischemia of different genesis - consequences of acute and chronic disorders of cerebral circulation (hemorrhages, blockage of cerebral arteries, craniocerebral trauma, intoxication).

Intellectual cognitive disorders (attention, memory, thinking) and emotional-volitional (apathy, irritability) spheres.

Psycho-organic disorders, especially those accompanied by adynamic and asthenic symptoms.

Inhibition of brain functions caused by various non-inflammatory causes (encephalopathy).

Diseases of the inner ear are not inflammatory, in particular, Meniere's disease.

Disturbance of blood supply to the eye membranes, dystrophic diseases of his retina, including those associated with age-related changes.

Cognitive disorders in pediatrics, in particular, in patients with decreased intelligence.

Asthenic syndrome.

Arterial hypertension.

Prevention of migraine and movement diseases - motion sickness, dizziness and other unwanted reactions of the body to acceleration and weightlessness.

Release form

Capsules containing active ingredients: piracetam - 0.4 g; cinnarizine - 0.025 g.

Auxiliary ingredients: milk sugar (lactose), pyrogenic silicon dioxide, emulsifier - magnesium stearate.

The capsule shell consists of gelatin and titanium dioxide. 


The active ingredients of the drug complement each other and enhance each other's action.

Piracetam has a beneficial effect on the brain departments responsible for learning-concentration of attention, the ability to memorize material, thinking, and also increases the threshold of intellectual fatigue.

Presumably, the nootropic effect of the drug consists in stimulating metabolic processes in neurons, changing the rate of transmission of excitation in the brain regions, improving cerebral circulation in ischemic areas by affecting the physico-chemical properties of the blood, without exerting a vasodilating effect. 

Over time, improves interneuronal conduction, reduces inhibition and improves memory functions. The connections between the left and right hemispheres of the brain are restored, activation of cognitive functions is observed and concentration of attention is improved.

Cinnarizine slows down the reduction in the number of cells in the muscle tissue of the cerebral vessels, blocking the channels permeable to calcium ions. As a result, the smooth muscle of the vessels relaxes, the reactive effect on the biogenic narrowing vessels of the elements (adrenaline, norepinephrine, dopamine, angiotensin, vasopressin) decreases. The brain vessels expand, and there is no noticeable hypotensive effect, as well as an effect on the heart rate.

Under the influence of cinnarizine, the cell membrane of erythrocytes becomes more elastic, which contributes to the dilution of blood. Increases cell resistance to oxygen starvation.

This active ingredient has the ability to suppress free histamine, reduces stimulation of the vestibular apparatus, exerts a tonic effect on the sympathetic nervous system and prevents the development of syncope.


Fezam is absorbed in the digestive canal at a good speed and almost completely. The concentration of Cinnarizine reaches its highest value after 60 minutes after ingestion. Splits completely and binds to serum proteins by 91%. About two thirds are excreted with feces unchanged, the rest is through the urinary system in the form of metabolic products.

The highest serum density of piracetam is fixed after oral administration after a time interval of two to six hours. This active ingredient easily overcomes the blood-brain barrier. Eliminated unchanged through the kidneys.

It should be noted that Fezam penetrates through the filters of the apparatus for hemodialysis.

Use of the fezama during pregnancy

The drug is not recommended for pregnant and lactating women, however, after the first trimester of pregnancy can be appointed for vital indications.  


Sensitization to any (active or ancillary) component of the drug, the first three months of pregnancy, the period of breastfeeding, age 0-4 years, severe forms of disruption of the kidney and / or liver are absolute contraindications.

Relative is considered ocular hypertension (after normalization it is allowed to apply), acute hemorrhagic or ischemic stroke, acute psychomotor agitation, porphyria.

Caution is prescribed for patients with Parkinson's disease or symptoms reminiscent of Huntington's chorea, kidney disease (dose adjustment is required depending on creatinine clearance), liver disease (control of hepatic enzymes activity), bleeding disorders. With prolonged courses of taking the drug to patients of advanced age, a dose adjustment may be necessary depending on the creatinine clearance.

Side effects of the fezama

Neuropsychiatric effects: disturbance of the regulation of excitation (hyperkinesia); coordination disorders; insomnia; headache; disturbance of the vestibular apparatus; fainting; complication of epileptic syndrome (increased frequency of attacks, imbalance); tremor; increased drowsiness up to lethargy; fast fatiguability; impotence; Parkinsonism; depressive state; anxiety; hallucinations, sexual arousal.

On the part of the gastrointestinal tract, dyspepsia, cholestatic jaundice, is possible.

Skin manifestations: puffiness, redness, itching, urticaria, photodermatosis, excessive sweating, flat red lichen, erythema.

Other: muscle rigidity; disorders of hematopoiesis; increase in body weight.

It should take into account some features of the drug: a positive result (false) is possible with doping control, the same applies to the sample for radioactive iodine. The drug can affect the reaction rate and concentration of attention.


Dosing and administration

Capsules should be swallowed whole one or two at a time three times a day at regular intervals after a meal, with plenty of water.

Duration of admission is determined by the attending physician depending on the severity of the symptoms of circulatory disorders and ranges from one to three months. After a three-month course, a break of at least a month is necessary.

trusted-source[5], [6]


The symptomatology of exceeding the recommended dose of the drug is expressed in the increase of its side effects. Single cases of acute overdosage were accompanied by severe dyspepsia in the form of diarrhea with blood, indomitable vomiting, abdominal pain, confused consciousness up to a coma, significant reduction in blood pressure, coordination disorders.

In childhood, the symptoms of an excited consciousness are more characteristic - insomnia, irritability, euphoric state, trembling of limbs, sometimes convulsions, hallucinations, nightmares.

The first aid is gastric lavage, the use of enterosorbents. Treatment is symptomatic, in severe cases, hemodialysis can help.

Interactions with other drugs

In combination with alcohol-containing preparations, alcoholic beverages, medicines and phytopreparations, which suppress the central nervous system, the soothing effect is enhanced. 

Synergistically acts with hypotensive, nootropic and vasodilating drugs.

With simultaneous admission with hypertensive drugs, their activity decreases.

It is possible to increase the effectiveness of thyroid hormones and oral anticoagulants in combination with Fezam.

The antihistaminic action of Cinnarizine can mask a positive skin reaction when testing for sensitivity to a drug, therefore, four days before the test, taking Fesam should be discontinued.

trusted-source[7], [8], [9], [10]

Storage conditions

Store at a storage temperature of 25 ℃. Keep away from children.

trusted-source[11], [12], [13]

Shelf life

3 years.



To simplify the perception of information, this instruction for use of the drug "Fezam" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.

Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.

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