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Fezam
Last reviewed: 03.07.2025

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A combined medicinal product that increases the resistance of brain cells to oxygen starvation, dilates and strengthens the blood vessels of the brain, and activates the flow of arterial blood to the ischemic area. Stimulates cognitive functions, intelligence, and also the activity of the central sections of the auditory and visual analyzers.
Indications Fezama
The presence of foci of ischemia of various origins is a consequence of acute and chronic cerebrovascular accidents (hemorrhages, blockage of cerebral arteries, traumatic brain injury, intoxication).
Disorders of the intellectual-cognitive (attention, memory, thinking) and emotional-volitional (apathy, irritability) spheres.
Psychoorganic disorders, especially those accompanied by adynamic and asthenic symptoms.
Depression of brain function caused by various non-inflammatory causes (encephalopathy).
Diseases of the inner ear of non-inflammatory origin, in particular, Meniere's disease.
Impaired blood supply to the membranes of the eye, degenerative diseases of the retina, including those associated with age-related changes.
Cognitive disorders in pediatrics, particularly in patients with reduced intelligence.
Asthenic syndrome.
Arterial hypertension.
Prevention of migraines and motion sickness – motion sickness, dizziness and other undesirable reactions of the body to acceleration and weightlessness.
Release form
Capsules containing active ingredients: piracetam – 0.4 g; cinnarizine – 0.025 g.
Excipients: milk sugar (lactose), pyrogenic silicon dioxide, emulsifier - magnesium stearate.
The capsule shell consists of gelatin and titanium dioxide.
Pharmacodynamics
The active ingredients of the medicine complement each other and enhance each other’s effects.
Piracetam has a beneficial effect on the parts of the brain responsible for learning - concentration, the ability to memorize material, thinking, and also increases the threshold of intellectual fatigue.
Presumably, the nootropic effect of the drug consists of stimulating metabolic processes in neurons, changing the rate of excitation transmission in parts of the brain, improving cerebral circulation in ischemic areas by influencing the physicochemical properties of the blood, without having a vasodilating effect.
Over time, interneuronal conductivity improves, inhibition decreases, and memory functions improve. Connections between the left and right hemispheres of the brain are restored, cognitive functions are activated, and concentration improves.
Cinnarizine slows down the reduction of the number of muscle cells in the vessels of the brain by blocking channels permeable to calcium ions. As a result, the smooth muscles of the vessels relax, the reactive effect on biogenic vasoconstrictor elements (adrenaline, noradrenaline, dopamine, angiotensin, vasopressin) decreases. The vessels of the brain expand, while there is no noticeable hypotensive effect, nor does it affect the heart rate.
Under the influence of cinnarizine, the erythrocyte cell membrane becomes more elastic, which helps thin the blood. Cellular resistance to oxygen starvation increases.
This active ingredient has the ability to suppress free histamine, reduces stimulation of the vestibular apparatus, has a tonic effect on the sympathetic nervous system and prevents the development of fainting.
Pharmacokinetics
Fezam is absorbed in the digestive tract at a good rate and almost completely. The concentration of Cinnarizine reaches its highest value 60 minutes after oral administration. It is completely broken down and binds to serum proteins by 91%. About two thirds are excreted with feces unchanged, the rest - through the urinary system in the form of metabolic products.
The highest serum density of piracetam is recorded after oral administration after a time interval of two to six hours. This active ingredient easily overcomes the blood-brain barrier. It is eliminated unchanged through the kidneys.
It should be taken into account that Fezam penetrates through the filters of the hemodialysis machine.
Dosing and administration
The capsules should be swallowed whole, one or two at a time, three times a day at equal intervals after meals, with a sufficient amount of water.
The duration of treatment is determined by the attending physician depending on the severity of the symptoms of circulatory disorders and ranges from one to three months. After a three-month course, a break of at least a month is required.
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Use Fezama during pregnancy
The drug is not recommended for pregnant and lactating women, however, after the first trimester of pregnancy it can be prescribed for vital indications.
Contraindications
Sensitization to any (active or auxiliary) component of the drug, the first three months of pregnancy, breastfeeding, age 0-4 years, severe forms of renal and/or hepatic impairment are absolute contraindications.
Relative conditions include ocular hypertension (it is permitted to be used after normalization), acute hemorrhagic or ischemic stroke, acute psychomotor agitation, and porphyria.
Use with caution in patients with Parkinson's disease or symptoms resembling it, Huntington's chorea, kidney disease (requires dose adjustment depending on creatinine clearance), liver disease (requires monitoring of liver enzyme activity), and blood clotting disorders. In elderly patients, dose adjustment may be necessary for long-term treatment depending on creatinine clearance.
Side effects Fezama
Neuropsychiatric effects: disturbance of excitation regulation (hyperkinesia); coordination disorders; insomnia; headache; disturbances of the vestibular apparatus; fainting; complication of epileptic syndrome (increased frequency of attacks, imbalance); tremor; increased sleepiness up to lethargy; rapid fatigue; impotence; parkinsonism; depressive state; anxiety; hallucinations, sexual arousal.
From the gastrointestinal tract, dyspepsia and cholestatic jaundice are possible.
Skin manifestations: swelling, redness, itching, urticaria, photodermatosis, increased sweating, lichen planus, erythema.
Others: muscle rigidity; blood disorders; weight gain.
Some features of taking the drug should be taken into account: a positive result (false) is possible during doping control, the same applies to the test for radioactive iodine. The drug can affect the reaction speed and concentration.
Overdose
Symptoms of exceeding the recommended dose of the drug are expressed in the increase of its side effects. Single cases of acute overdose were accompanied by severe dyspepsia in the form of diarrhea with blood, uncontrollable vomiting, sharp abdominal pain, confusion up to a comatose state, a significant decrease in blood pressure, and coordination disorders.
In childhood, symptoms of excited consciousness are more typical - insomnia, irritability, euphoric state, trembling of the limbs, sometimes convulsions, hallucinations, nightmares were observed.
First aid – gastric lavage, use of enterosorbents. Treatment is symptomatic, in severe cases hemodialysis can help.
Interactions with other drugs
In combination with alcohol-containing drugs, alcoholic beverages, medicines and herbal preparations that depress the central nervous system, the sedative effect is enhanced.
It acts synergistically with antihypertensive, nootropic and vasodilator drugs.
When taken simultaneously with hypertensive drugs, their activity decreases.
It is possible to increase the effectiveness of thyroid hormones and oral anticoagulants in combination with Fezam.
The antihistamine action of Cinnarizine can mask a positive skin reaction when testing for sensitivity to any drug, so four days before the test, Fezam should be discontinued.
Storage conditions
Shelf life
3 years.
Attention!
To simplify the perception of information, this instruction for use of the drug "Fezam" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.