Fencarol

Fenkarol has anti-allergic properties and helps reduce swelling.

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Indications Fencarol

It is used to treat disorders such as urticaria or hay fever, as well as allergies to food products or therapeutic agents, and other diseases of allergic origin.

Along with this, the medication can be prescribed in the following situations:

• various dermatoses ( eczema, itching, and neurodermatitis);
• rhinopathy of allergic etiology;
• Quincke's edema;
• reactions to various allergens, which cause bronchial spasms.

Release form

The drug is produced in the form of a medicinal solution and tablets. The solution is packaged in ampoules with a capacity of 1 or 2 ml (in a separate box - 10 pieces), and the tablets - in blister plates (in the amount of 10 pieces), 2 blisters per box.

Pharmacodynamics

The active ingredient of the drug is a derivative of quinuclidine carbinol, which weakens the activity of histamine (it is produced as an immune response to the effect of an allergen). The structure of the substance contains a cyclic quinuclidine nucleus, and it itself is located at a significant distance between the category of diphenylcarbinol, as well as nitrogen.

The element khifenadine helps block H1-endings using the competitive principle, and during this process it activates the activity of the enzyme diamine oxidase. This enzyme helps break down histamine (about 30%). Due to these properties, Fenkarol demonstrates higher efficiency in comparison with other antiallergic drugs.

The drug hardly penetrates the BBB, exerting only a weak effect on the processes of serotonin deamination inside the brain, as well as on MAO.

The medicine helps to remove spasms affecting smooth intestinal muscles, as well as itching and discomfort caused by allergies. It also reduces the antihypertensive effect and strengthens capillary strength, while not affecting the heart muscles and blood pressure.

Fenkarol differs from the well-known drugs pipolfen and diphenhydramine in that it does not suppress the central nervous system, and is present in very small amounts inside the brain tissue. However, when a patient develops a specific response to medicinal elements, a weak sedative effect may appear.

Pharmacokinetics

After intramuscular injections, peak drug levels are observed after half an hour. When taking tablets orally, similar values are observed after 60 minutes.

The accumulation of the drug is mainly carried out in the kidneys with the liver and lungs. Then the substance undergoes metabolic transformations, and its decay products are then excreted in the urine.

Dosing and administration

The drug is used in the appropriate therapeutic form, taking into account the patient's age, signs of the disease and side effects. Tablets should be taken after meals, while washing them down with plain water or some other liquid.

Use of tablets containing 25 mg.

For an adult, the standard dosage is 1-2 tablets taken 3-4 times a day. In total, a maximum of 0.2 g of the drug is allowed per day.

Teenagers over 12 years of age are required to take 50-75 mg of the drug per day (thus, the dosage regimen is 1 tablet taken 2-3 times a day).

Such therapy usually lasts for 10-20 days.

Use of children's Fenkarol (tablet volume - 10 mg).

The medicine is taken orally. For children aged 3-7 years, the dosage is 1 tablet 2 times a day. Children aged 7-12 years are prescribed to take 1 tablet 2-3 times a day. Teenagers over 12 years of age are recommended to take 2 tablets of the drug 2-3 times a day.

The treatment cycle should be drawn up by the attending pediatrician. Usually it is 10-15 days.

Scheme of application of the medicinal substance for intramuscular injections.

To treat hay fever, injections are required, the dosage of which is 2 ml, twice a day, for 3 days. Then the portion size is reduced to 2 ml (single injection per day), which must be administered for another 2 days.

For the treatment of urticaria or angioedema, 2 ml of the drug should be administered twice a day for the first 5 days, and then 2 ml once a day for another 3 days.

One injection of the drug may contain no more than 2 ml of the substance (20 mg), and a maximum of 4 ml (40 mg of the drug) may be administered per day.

After the acute allergy symptoms have been relieved, the patient must be transferred to taking Fenkarol tablets.

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Use Fencarol during pregnancy

Fenkarol should not be prescribed during the first trimester of pregnancy.

Contraindications

Main contraindications:

• the presence of hypersensitivity to the components of the therapeutic agent;
• lactation period.

The drug should be used with caution in people with diseases affecting the kidneys, intestines and stomach, liver, and cardiovascular system.

Side effects Fencarol

The development of negative symptoms is noted only occasionally. If the patient has high sensitivity to quifenadine, the following effects may occur:

• development of dry oral mucosa;
• a bitter taste in the mouth, as well as indigestion;
• vomiting or severe nausea;
• subtle sedative effect (feeling of lethargy or drowsiness);
• loss of consciousness and severe headaches.

In the presence of diseases affecting the function of the gastrointestinal tract, the risk of negative symptoms increases.

If a patient experiences any of the above symptoms, they should immediately consult a specialist.

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Overdose

When consuming up to 0.3 g of the drug per day, no serious complications in the functioning of the body were recorded.

If symptoms such as vomiting, stomach pain and indigestion, dry mouth, headaches and nausea develop, it is necessary to give the patient activated charcoal and also perform the required symptomatic procedures.

Interactions with other drugs

The combination with Fenkarol can lead to changes in blood levels of drugs that are characterized by slow gastric absorption (including coumarins).

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Storage conditions

Fenkarol must be stored under standard conditions required for storage of therapeutic drugs.

Shelf life

Fenkarol in tablet form can be used within 5 years from the date of manufacture of the drug, and the injection liquid has a shelf life of 24 months.

Application for children

Persons under 18 years of age are prohibited from receiving the injection liquid.

Tablets in a special form for children, containing 10 mg of the active element, can be prescribed to patients under 12 years of age.

Analogues

Analogues of the drug are Alergostop, Alerik, Loran with Alersis and Alernova, and in addition to this, Alergomax, Kestin, Loratadine with Gistafen, Edem with Lordes and Diazolin with Fexomax. The list also includes Ketotifen, Tigofast, Erolin with Lorisan and Erius, and along with this, Semprex, Trexil Neo, Peritol, Fexofen-Sanovel with Fribris, Altiva, Eridez with Telfast, Claritin, Fexofast and Lorano ODT.

Reviews

Fenkarol receives mostly positive reviews from patients who have taken it. It works well for severe bronchial spasms, and also eliminates swelling that occurs due to acute respiratory infections, bronchitis or rhinitis. Its advantages include low cost and high-quality effects. Its disadvantages include negative symptoms, most often including a bitter taste and nausea.

The drug also gets good reviews as a treatment for children. It is often used as a first aid medication (for example, when a child eats something potentially dangerous) or in case of very intense allergy symptoms, during which swelling is observed. Children also tolerate Fenkarol (children's) well.

Some commentators in their reviews highlight the impossibility of using the drug for infants under 1 year of age as a disadvantage.