Fenkarol

Fenkarol has anti-allergic properties, it helps to reduce swelling.

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Indications Fenkarola

It is used to treat disorders such as hives or hay fever, and in addition allergies to foods or therapeutic agents, and other diseases of allergic origin.

Along with this, the medication can be prescribed in such situations:

• various dermatoses ( eczema, itching, and also neurodermatitis);
• the rhinopathy having an allergic etiology;
• edema of Quincke;
• reactions in relation to various allergens, against which bronchial spasms are noted.

Release form

Release of drugs is realized in the form of drug solution and tablets. The solution is packed into ampoules with a capacity of 1 or 2 ml (in a separate box - 10 pieces), and tablets - in blister plates (in the number of 10 pieces), 2 blisters per box.

Pharmacodynamics

The active element of the drug is the derivative of quinuclidyl carbinol, which weakens the activity of histamine (it is produced as an immune reaction to the effect of an allergen). The structure of the substance contains a cyclic quinuclidine nucleus, and it itself is located at a significant distance between the category of diphenylcarbinol, as well as nitrogen.

The element hifenadine promotes the blocking of H1-terminations, using a competitive principle, and in the course of this process activates the activity of the diaminoxidase enzyme. This enzyme helps to break down histamine (about 30%). Due to these properties Fenkarol and demonstrates a higher effectiveness in comparison with other antiallergic drugs.

The drug hardly penetrates the BBB, having only a weak effect on the processes of serotonin deamination inside the brain, as well as at the MAO.

The medicine helps to remove spasms affecting smooth intestinal muscles, and besides itching and discomforting sensations that appear due to allergies. It also reduces the antihypertensive effect and strengthens the capillary strength, at the same time without affecting the musculature of the heart and the level of pressure.

Fenkarol differs from the fairly well-known preparations of pifolen and diphenhydramine in that it does not suppress the work of the central nervous system, and inside the brain tissue is present in very small volumes. But when the patient develops a specific response to the medicinal elements, a weak sedative effect may appear.

Pharmacokinetics

After intravenous injections peak values of the drug are noted after a half an hour. When oral tablets are taken, similar values are observed after 60 minutes.

Cumulation of the medication is mainly carried out inside the kidneys with the liver and lungs. Further, the substance undergoes metabolic transformations, and its decay products are then excreted in urine.

Dosing and administration

The drug is used in appropriate therapeutic form, taking into account the age of the patient, signs of illness and side symptoms. You need to take the pill after eating, while washing them with plain water or some other liquid.

The use of tablets having a volume of 25 mg.

For an adult, the standard dosage is 1-2 tablets, which take 3-4 times a day. Totally per day allowed to take a maximum of 0.2 g of drugs.

Adolescents over 12 years of age are required to take 50-75 mg of the drug per day (thus, the regimen is 1 to 2 tablets with a 2-3-time application).

Such therapy usually lasts within 10-20 days.

Use of infant Fenkarol (tablet volume - 10 mg).

The medicine is used orally. For children of the age group 3-7 years, the dosage is 1 tablet 2 times a day. Children aged 7-12 years are prescribed to take the 1st pill 2-3 times a day. Adolescents over 12 years of age are recommended to use 2 tablets of medicines 2-3 times per day.

The treatment cycle should be made by the attending pediatrician. Usually it is 10-15 days.

Scheme of drug substance application for intramuscular injections.

For treatment of pollinosis it is required to perform injections, the dosage of which is 2 ml, twice a day, for 3 days. Further, the size of the portion is reduced to 2 ml (one-time injection of the injection per day), which are required to enter for another 2 days.

For therapy with urticaria or angionevrotic edema for the first 5 days, it is required to administer 2 ml of the drug twice a day, and then once a day for 2 ml - for another 3 days.

A single injection of the drug can contain no more than 2 ml of the substance (20 mg), and a maximum of 4 ml (40 mg of the drug) is allowed in a single day.

After relief of acute allergy symptoms, it is required to transfer the patient to Fenkarol tablets.

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Use Fenkarola during pregnancy

Do not prescribe Fenkarol for the 1st trimester of pregnancy.

Contraindications

The main contraindications:

• the presence of hypersensitivity to the components of the therapeutic agent;
• lactation period.

With caution the medication is used in people with diseases affecting the kidneys, intestines with stomach, liver, and also CCC.

Side effects Fenkarola

The development of negative symptoms is noted only sporadically. If the patient has a high sensitivity to hifenadine, such effects can occur:

• development of dry mouth mucosa;
• a bitter taste in the mouth, as well as gastric indigestion;
• vomiting or severe nausea;
• unobtrusive sedative effect (feeling of inhibition or drowsiness);
• loss of consciousness and severe headaches.

In the presence of diseases affecting the function of the gastrointestinal tract, the risk of negative symptoms increases.

If the patient has a development of any of the above manifestations, you should immediately consult with a specialist.

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Overdose

When you consumed up to 0.3 grams of medication a day, there were no serious complications in the functioning of the body.

When developing such manifestations as vomiting, stomach pain and indigestion, dry mouth mucosa, headaches and nausea, it is necessary to give the patient an activated charcoal, as well as perform the required symptomatic procedures.

Interactions with other drugs

Combination with Fenkarol can lead to a change in blood levels of drugs that are characterized by slow gastric absorption (among these coumarins).

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Storage conditions

Fenicarbon should be kept under standard conditions required for the storage of therapeutic drugs.

Shelf life

Fenkarol in tablet form can be used within 5 years from the date of release, and the injection liquid has a shelf life of 24 months.

Application for children

Persons under the age of 18 are not allowed to prescribe an injection liquid.

Tablets in a special form for children, containing in their composition 10 mg of the active element, can be prescribed to patients under 12 years of age.

Analogues

The analogues of the medication are Alergostop, Aleric, Laurent with Alersis and Alernova, and besides Alergomax, Kestin, Loratadin with Histafen, Eden with Lorddes and Diazolin with Fexomax. The list also includes Ketotifen, Tigofast, Erolin with Lorisan and Erius, and along with this Semprex, Trexil Neo, Peritol, Feksofen-Sanovel with Fribris, Altiva, Eridez and Telfast, Claritin, Thexophastus and Lorano Cott.

Reviews

Fenkarol receives mostly positive feedback from his patients. It works well for spasms of bronchi in a severe degree, and also eliminates edemas that arise due to ARI, bronchitis or rhinitis. Among its advantages are low cost and quality impact. Of the minuses - negative symptoms, of which most often give off a bitter taste and nausea.

The drug receives good reviews and as a means for treating children. Often it is used in the form of a first-aid medicine (for example, when a child eats something potentially dangerous) or with very intense allergy manifestations, during which swelling is noted. Children also tolerate Fenkarol (child) well.

Separate commentators in their reviews highlight as a drawback the inability to use drugs for infants who have not reached the age of 1.