Femoden

Femoden has estrogen-gestagenic and contraceptive properties.

[1]

Indications of the femodena

It is used as a contraceptive. In addition, it can be used to stabilize the menstrual cycle and relieve extremely heavy menstrual bleeding.

[2], [3],

Release form

The release occurs in the form of a dragee, inside the blister plates.

[4], [5]

Pharmacodynamics

The drug is part of a group of drugs that have a low hormone dosage. It affects the system, which includes the pituitary gland with the hypothalamus and the ovaries.

The drug depresses the process of binding hormones that stimulate follicular maturation. It also causes a slowdown in ovulation and activates the changes that occur in the processes of separation of cervical mucus.

Femodena does not have androgenic activity. In addition, it reduces the susceptibility of the endometrium to the consolidation of the blastocyst.

[6]

Pharmacokinetics

When ingested, ethinyl estradiol with gestodene is absorbed completely and at high speed. At the 1st hepatic pass, Gestodene does not undergo cleavage, but the greater part of ethinylestradiol, on the contrary, enters the metabolic processes. The latter is also more synthesized with an intraplasma protein. In addition, it passes into the mother's milk.

The level of bioavailability of the drug is 99%. Gestodene is synthesized with plasma albumin, capable of binding sex steroids, and at the same time with globulin.

Excretion of Gestodene and Ethinyl estradiol takes place in the form of decay products - with bile and urine.

[7], [8], [9]

Dosing and administration

The medicine must be consumed inside, every day and at about the same time of the day. Dragee swallowed whole, washed down with ordinary water. Take the drug on the 1st dragee during the 21st day. Then the patient should make a 7-day break, then resume the procedure. Menstrual bleeding often begins on the 2nd-3rd day after the start of the break and can end before switching to a new pack of drugs.

Women who have not previously used any hormonal contraceptive drugs should take Femoden from the first day of the menstrual cycle beginning or from the 2nd to the 5th day. At the same time, it is recommended to use additional contraceptives during the first week of the course.

Women who had previously taken other complex medications for ingestion should take the medicine on the next day after the last drug. It is forbidden to begin reception later the next day after the end of the standard 7-day break for the period of menstruation.

When switching from medications containing solely gestagens, or from intrauterine devices releasing gestagen, you can start taking Femodena from any day. If an intrauterine device or implant was used, the course begins immediately on the day it is removed. If a solution was applied, the intravenous injection - the beginning is the next day. At this time on the first week of the course you need to use additional (barrier) contraceptives.

Women who have had an abortion on the 1st trimester should start taking drugs immediately. There is no need for additional protective equipment. Those who have had an abortion on the 2nd trimester or after childbirth, it is recommended to start using the drug after 3-4 weeks. At the beginning of use in a later period, it is required to make sure of the absence of pregnancy and the first time to use additional contraception.

If you miss a drug intake (for a period of less than 12 hours), its contraceptive effect will still be effective. Take medication as quickly as possible, and use the next portion at standard time. If you miss an application with a duration of more than 12 hours (but no longer than 7 days), the dose should be used as soon as possible. Then the medicine is taken as usual. During the whole of the next week should be protected from pregnancy by additional means. In addition, it is necessary to exclude the possibility of an existing pregnancy.

If you skip the use of the drug for a period longer than 12 hours at week 3, you need to take it as quickly as possible, after that continuing use at the standard time before the start of a new pack. Before it ends, the probability of bleeding is rather low. In this period, when taking drugs, there may be secretions of smearing type and small bleeding. At the same time, it is allowed to make a standard 7-day break after the end of the 1st package, and only then start a new one.

If you miss a dose and miss no menstrual bleeding in a standard 7-day break, you must definitely exclude the possibility of pregnancy.

If a woman develops diarrhea or vomiting during the first 4 hours after using the medication, additional barrier contraception should be used for protection. In addition, it is necessary to focus on the application schemes for skipping reception.

There are also situations where a delay in the menstrual cycle is required. In this case, the drug should continue to be used, without observing a 7-day break, during the required period, until the end of the second pack. At this time, there may be weak bleeding, and in addition, highlighting the smearing character. At the end of the 2nd package, a 7-day break is mandatory.

[14], [15], [16]

Use of the femodena during pregnancy

The use of Femodena during pregnancy is prohibited.

Contraindications

The main contraindications:

• the presence of high sensitivity with respect to drug components;
• hepatic tumors (also their presence in the anamnesis);
• migraine (in anamnesis accompanied by focal reactions that had a neurological character);
• a severe stage of diabetes mellitus, accompanied by complications in the vascular system and severe form of hypertriglyceridemia;
• bleeding from the uterus, having an unknown nature;
• severe stages of functional hepatic disorders;
• thromboembolism (also its presence in the anamnesis or a high probability of its occurrence);
• pancreatitis, accompanied by a severe stage of hypertriglyceridemia (also having a history).

[10], [11], [12]

Side effects of the femodena

The use of medication can trigger the appearance of such side effects:

• chloasma, urticaria, hypersensitivity to contact lenses, rashes, anaphylaxis and angioedema;
• nausea with vomiting and changes in weight;
• fluid retention, discharge from the nipples, pain in the chest, change in vaginal discharge or libido, and in addition, engorgement of the mammary glands;
• headaches, migraine, mood lability;
• tachycardia.

[13],

Overdose

Poisoning with medication can cause tachycardia, bleeding from the vagina, vomiting with nausea and smearing discharge.

There is no Antidote for Femodena. Select a treatment scheme should be a gynecologist.

Interactions with other drugs

Individual antibiotics can lead to a decrease in the values of the active elements of the drug within the blood plasma. In addition, medications such as phenylbutazone and hydantoin with rifampicin can weaken its effectiveness.

[17], [18], [19], [20]

Storage conditions

Femoden must be kept at a temperature that does not exceed 25 ° C.

Shelf life

Femoden is allowed to be used for 5 years from the date of manufacture of the drug.

Reviews

Femoden receives a lot of different opinions on the forums, but they do not write negative opinions about him. Although many women note the presence of many negative symptoms. Often complain of vomiting with nausea, mood lability and weight gain. But those to whom the medicine has approached, speak about it only positively.

Doctors confirm that the drug can cause the development of negative manifestations - often due to the fact that these people simply do not fit the drug. In addition, it is often prescribed to patients not only as a contraceptive, but also for the treatment of inflammation in the endometrium (in combination with anti-inflammatory therapy). Sometimes, Femoden is used before the IVF procedure (in situations where before it was an unsuccessful protocol).