Faspik

The widely known nonsteroidal anti-inflammatory drug ibuprofen, an effective antipyretic analgesic, is now presented by Swiss pharmacists in a new dosage form of granules for the preparation of an oral solution flavored with various flavoring agents masking the bitter taste of the active ingredient.

Under this trade name Faspik, a tablet form is also available in the form of a salt of the L-isomer of aliphatic acid arginine, which contributes to a certain increase in the digestibility and effectiveness of ibuprofen. 

Indications of the faspica

Symptomatic relief of joint, muscle, head, menstrual, dental, neuralgic pain, in addition - pain and febrile syndrome, associated with acute viral infections, flu and colds. 

Release form

This medication is available in solid form of gastroplasty coated tablets that contain 0.4 g of active ingredient - ibuprofen, and also in granular form for the preparation of a warm drinking solution packaged in sachets:

• Faspik with mint flavor contains 0.2 g of active ingredient and auxiliary substances: sodium bicarbonate, synthetic sweetener - aspartame, L-arginine, saccharinate, cane sugar, food flavoring "mint";
• Faspik with apricot flavor is produced in two versions of the active ingredient dosing at 0.4 and 0.6 g, differs from the previous species in the presence of "apricot" flavor in the food flavoring;
• Faspik with mint-anise taste is produced in two versions of the active ingredient dosing at 0.4 and 0.6 g, in the auxiliary composition of this species contains two food flavors - mint and anise.

         In all forms, the active ingredient (ibuprofen) is contained as the salt of the L-isomer of aliphatic acid arginine.

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Pharmacodynamics

The effect of this drug is determined by the presence in its composition of ibuprofen - a non-hormonal substance that reduces the production of inflammatory mediators. The mechanism of this phenomenon is associated with the suppression of the enzymatic activity of cyclooxygenase, a catalyst for the production of prostaglandins from arachidonic acid. A decrease in their number in the hypothalamic center of thermoregulation causes a decrease in the body temperature of the patient, while only an abnormally high temperature is selectively reduced, if this is normal, then there is no reduction.

As a result of a decrease in the level of prostaglandins, the sensitivity to mediators of pain decreases.

Inhibition of cyclooxygenase also affects the synthesis of the endogenous thromboxane proagregant, diluting the blood and exerting a thrombolytic effect.

Pharmacokinetics

The active substance is absorbed with good speed in the digestive tract and distributed in the tissues of the body. The maximum plasma content is determined after 15 minutes, sometimes this period is prolonged, but does not exceed half an hour from the moment of reception. 

Splitting occurs in the liver, excreted in the urine in the form of inactive metabolites. The half-cycle of active substance circulation in the blood is from one to two hours.

Dosing and administration

To reduce the likelihood of developing digestive disorders, it is recommended that the drug be taken with food.

Patients of advanced age, and also - with pronounced organic or functional impairment of vital organs, the dose is adjusted downwards.

Tablets: at the beginning of the treatment, one tablet per dose is taken, no more than 1.2 g of the drug can be taken per day, the interval from one dose to the next should be at least four hours. The tablet is swallowed whole, washed down with clean water in the volume necessary for this.

The solution is prepared as follows: the granules from the sachet are poured into ½ cup of warm boiled water, dissolve, slightly shaking. Take immediately after dissolution. The rules of reception are similar to tablets.

The maximum single dose of the active substance is 0.6 g.

The duration of any form should not exceed a week.

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Use of the faspica during pregnancy

The drug is contraindicated in pregnant women and nursing mothers, in addition - it is not recommended for patients planning a pregnancy.

Contraindications

1. Sensitization to the ingredients of the drug, to the history of NVP (in particular - aspirin triad).
2. Pregnancy and lactation.
3. The course of treatment with another cyclooxygenase inhibitor.
4. Low prothrombin index, hemorrhagic diathesis, bleeding tendency, unspecified, hemophilia.
5. Phenylketonuria.
6. Gastrointestinal hemorrhages, perforations and ulcerative-erosive lesions, acute and in anamnesis.
7. Expressed and progressive heart, kidney and liver failure.
8. Age 0-11 years, for a dose of 0.6g - 0-18 years.
9. Pathologies of the optic nerve.
10. Hyperkalemia.
11. Congenital enzymatic insufficiency of sucrose-isomaltase, fructosemia, galactosemia.

Be wary of elderly patients suffering from diabetes, collagen, kidney problems, bronchial asthma and bronchial prone bronchial spasmodic medications that increase the likelihood of hemorrhages.

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Side effects of the faspica

With short-term treatment with this drug, skin and respiratory allergic reactions are most likely to develop up to anaphylactic shock.

Prolonged reception can provoke the development of the following phenomena:

Organs of digestion: abdominal pain, nausea, vomiting (possibly with a trace of blood), bloating, diarrhea, heartburn and other digestive disorders, erosive and ulcerative lesions along the digestive tract, gastrointestinal hemorrhages (possibly intense with a risk of fatal outcome); there is a risk of inflammatory processes in the pancreas, esophagus or duodenum, Crohn's disease, jaundice, hepatonecrosis, liver inflammation and disruption of its functions.

Neurology: migraine-like pain, not amenable to cupping by non-narcotic analgesics, even in high doses; dizziness, tinnitus, drowsiness, emotional lability, or, on the contrary, increased excitability, insomnia, anxiety, anxiety, muscular spasms, hearing impairment.

Genitourinary system: acute disruption of kidney function, urination disorders, inflammatory and degenerative processes along the urethra, impairment of fertility;

Organs of hematopoiesis: agranulocytosis, anemia (including aplastic), a decrease in the quantitative indicators of the content of blood cells: leukocytes, platelets, erythrocytes, an increase in the level of eosinophils;

Heart and blood vessels: a sharp decrease in blood pressure until the development of coma; disturbances in the rhythm of the heart, increased heart rate; symptoms of cardiac and cerebral vascular insufficiency; high doses of the drug can trigger the development of acute stroke, thromboembolism of the artery.

Sensitization reactions: from hives and allergic rhinitis to shock.

Eyes: violation of color perception, clarity of vision, "lazy eye".

In persons with collagenosis, aseptic meningitis may develop.

The risk of undesirable effects of taking the drug is significantly reduced with short-term use with minimal effective dosing. 

Overdose

Exceeding the recommended dosages can cause either side effects or a combination of them in an acute form up to a lethal state.

Therapy is performed according to the symptoms. If the time interval from the moment of taking a large amount of medicine is no more than half an hour, you can wash the stomach and give activated charcoal or enterosgel. The antidote is not known.

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Interactions with other drugs

Combined reception with ibuprofen of the following medicines can provoke the consequences:

• the formation of multiple erosive and ulcerative lesions of the mucosa of the digestive tract and bleeding from them - drugs that selectively inhibit the synthesis of serotonin, prevent the formation of thrombi, glucocorticosteroids;
• decrease in the effectiveness of hypotonic and diuretic drugs;
• increased plasma concentrations of cardiac glycosides, methotrexate and lithium;
• strengthening the effect of drugs that reduce blood clotting and sugar levels;
• the toxic effect of cyclosporine and tacrolimus on the kidneys increases;
• reduction in the efficacy of mifepristone (the interval between doses should be at least eight days);
• increase the likelihood of convulsive syndrome in patients taking antibiotics of the quinolone group.

You should not combine Faspik with other NVPs and with alcoholic beverages.

Patients with HIV infection who take zidovudine should be aware that the simultaneous administration of Faspic increases the risk of hemarthrosis and bruising.

[7], [8]

Storage conditions

Keep in accordance with the temperature range of 15-25 ℃. Keep away from children.

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Shelf life

3 years.