Ezolong

One of the most common means for treating peptic ulcer and gastroesophageal reflux is Ezolong, an antiulcer drug, the so-called proton pump inhibitor, whose main substance is esomeprazole.

Indications Ezolong

 Ezolong is prescribed as a primary or auxiliary drug in the following situations:

• with erosive reflux esophagitis;
• to prevent the recurrence of esophagitis;
• for relief of the condition with reflux disease;
• with an ulcer of the duodenal ulcer, provoked by Helicobacter pylori;
• for the prevention of recurrent ulcer disease in patients with Helicobacter pylori lesions;
• with ulcers caused by the use of non-steroidal anti-inflammatory drugs;
• for the prevention of ulceration with the administration of non-steroidal anti-inflammatory drugs;
• with the syndrome of Zollinger-Ellison.

Release form

Ezolong is produced in the form of tablets with a film-coated coating. One tablet may contain 20 or 40 mg of the active ingredient of esomeprazole.

Appearance of the tablet: oval, convex on both sides, slightly pinkish shade (40 mg) or yellowish tinge (20 mg), with a transverse incision for dosing on one side.

Aluminum blister plate contains 7 tablets. One package of cardboard contains one or two blister plates, as well as instructions for this product.

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Pharmacodynamics

Ezolong is an active ingredient of esomeprazole, the s-isomer of omeprazole, which is known as an agent that inhibits gastric secretion. Esomeprazole is a specific proton pump inhibitor drug with directed pharmacodynamic activity.

The active ingredient of the preparation of Azolong belongs to weak bases - the substance accumulates and is activated in the acid medium of the excretory channels of parietal cellular structures, where the inhibition of the enzyme H + K + ATPase - acid pump, as well as the inhibition of acid production.

Pharmacokinetics

The drug is absorbed rapidly, reaching high concentrations for half an hour after the use of the dosage. Full bioavailability can be 90%. The connection with plasma proteins is 95%.

Simultaneous consumption of food reduces absorption and slows down the assimilation of Esolong.

The drug is metabolized with the participation of the cytochrome P450 system. A higher percentage of metabolism is dependent on CYP3A4, responsible for the formation of esomeprazole sulfone, the main plasma metabolite.

The half-life is 60-90 minutes. The ratio of plasma concentration and time increases with repeated use of the medication. This increase depends on the dosage of Esolong and provokes a non-linear dependence of the "dosage-AUC" type with repeated admission.

Such a time dependence is due to a decrease in the metabolism of the first passage, as well as indicators of systemic clearance due to inhibition of the CYP2C19 enzyme.

The active substance is fully excreted from the bloodstream during the period between doses of regular doses, without accumulation, with daily intake of Azolong 1 time per day.

The presence of basic metabolic products does not show any effect on the production of gastric juice. Approximately 80% of the taken amount of the drug leaves the body with the urinary fluid, and the remaining amount - with the calves.

Dosing and administration

Ezolong is taken one hour before eating, squeezed with water. Tablets are not crushed or chewed.

With erosive form of esophagitis reflux, 40 mg of medication is prescribed daily, throughout the month.

To eliminate the symptoms of gastroesophageal reflux disease, 20 mg are prescribed daily, provided there is no esophagitis.

As a prolonged prophylaxis of recurrent esophagitis, 20 mg of the drug are prescribed daily.

When Helicobacter pylori and duodenal ulcer are diagnosed, 20 mg of Azolongum with Amoxicillin and Clarithromycin are administered twice a day for a week.

To prevent recurrence of Helicobacter pylori and peptic ulcer, 20 mg of Ezolong with Amoxicillin and Clarithromycin are prescribed twice a day for a week.

For the treatment of ulcers caused by the use of non-steroid anti-inflammatory drugs, appoint 20 mg of the drug daily, for 1-2 months.

To treat the Zollinger-Ellison syndrome, take 40 mg of the drug twice a day. However, the dose can be changed, depending on the clinical indication. Admission is allowed from 80 to 160 mg of the drug per day (divided into 2 divided doses).

If the kidney or liver function is impaired, as well as for elderly patients, it is not necessary to adjust the amount taken.

Use Ezolong during pregnancy

Clear and reliable information about the use of the drug Ezolong during pregnancy is absent, which does not allow to recommend this drug to use in pregnant patients.

There is also no information on the possibility of drug treatment during lactation.

Contraindications

Ezolong is contraindicated:

• with hypersensitivity to the drug;
• children under the age of 12;
• in combination with medicines Atazanavir and Nelfinavir.

Side effects Ezolong

Treatment with the drug Ezolong can be accompanied by some undesirable effects:

• a decrease in the number of leukocytes or platelets in the blood;
• allergy, anaphylaxis;
• edema of the extremities associated with the disorder of metabolic processes;
• sleep disorders;
• states of overexcitation, depression;
• pain in the head, fatigue;
• disorder of visual function, hearing;
• dizziness;
• phenomena of bronchospasm;
• dyspepsia, abdominal pain;
• thirst;
• jaundice, hepatitis;
• dermatitis, skin rashes, zonal baldness;
• pain in the joints and muscles;
• increased sweating.

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Overdose

Information on the overdose of Ezolong is not enough. Signs of damage to the digestive system and a sense of weakness occurs after oral administration of 280 mg of the drug.

Specific antidote is not installed.

Hemodialysis is considered to be ineffective, therefore, when an overdose is limited to symptomatic treatment and supporting therapeutic measures.

Interactions with other drugs

The presence of reduced gastric acidity when taking Ezolong can affect the absorption of medications, if the processes of their assimilation depend on the degree of acidity. It is noted that the use of other drugs inhibiting the production of acid, as well as antacids, provokes a decrease in absorption of ketoconazole or Intraconazole during the period of therapy with Ezolong.

Ezolong, combined with medications that metabolize CYP2C19 (diazepam, phenytoin, imipramine) can cause an increase in the concentration of the listed drugs. Given this, it is necessary to lower their dosage.

The combined administration of 30 mg of Azolong will result in a reduced clearance of the substrate of Diazepam by 45%.

The combined use of Ezolong will lead to an increase in the concentration of phenytoin in the serum in people with epilepsy. It is necessary to control the amount of the drug in the bloodstream at the time of prescribing or abolishing the Ezolong.

Admission Ozolong in combination with the medication Warfarin requires control of the quality of blood coagulability.

The combination with Voriconazole and other inhibitors of CYP2C19 and CYP3A4 can lead to an increase in exposure of the active component of Esolong by more than two times, which, however, does not require correction of the dosage of the drug.

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Storage conditions

Ezolong is stored in the factory packaging at a temperature of up to + 25 ° C, outside the children's access area.

Shelf life

Ezolong can last up to 2 years, with proper storage conditions.