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Erius
Last reviewed: 07.06.2024

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The drug Erius is a trade name for the active ingredient desloratadine. Desloratadine belongs to the class of antihistamine drugs and is used to relieve the symptoms of allergic reactions. Here is a brief description of Erius:
- Indications for use:
- Seasonal and year-round allergic rhinitis (runny nose) accompanied by itchy nose, sneezing, runny nose and stuffy nose.
- Urticaria (or chronic idiopathic urticaria) is an allergic skin disease characterized by the appearance of red, itchy, swollen patches or papules on the skin.
- How to use: The drug is usually taken orally in the form of tablets, solution or syrup, according to the doctor's recommendations or instructions for use.
- Side effects: Side effects of Erius may include drowsiness, dizziness, fatigue, headache, dry mouth and rarely - gastrointestinal disorders. In case of serious undesirable effects, you should contact your doctor.
- Contraindications: The drug is contraindicated in case of known individual intolerance to desloratadine or other components of the drug, as well as in pregnancy and during breastfeeding without a doctor's prescription.
Before using Erius, it is important to consult your doctor for advice on dosage and duration of treatment, especially if you have any medical problems or are taking other medications.
Indications Eriusa
- Allergic Rhinitis: Includes seasonal or year-round runny nose, sneezing, stuffy nose, itchy nose and eyes caused by allergic reactions to pollen, dust, down, fluff, mold, animals and other allergens.
- Urticaria: This skin allergic condition is characterized by the appearance of red, itchy, swollen patches of skin that can range in size from small spots to large plates.
- Associated symptoms of allergic reactions: Erius may also be used to relieve other symptoms associated with allergic reactions such as itchy eyes, tearing and allergic cough.
Release form
- Tablets: Erius comes in tablet form for oral (by mouth) administration. The tablets are usually coated to make them easier to swallow. The tablets are available in different dosages, such as 5 mg.
- Syrup: For patients, especially children, who have difficulty swallowing hard tablets, Erius can be provided as a syrup. The syrup has a pleasant taste and makes it easier for children to take.
Pharmacodynamics
- Histamine receptor antagonism: Desloratadine is an antagonist of histamine H1 receptors. It competes with histamine for binding to these receptors, blocking their activation. This has the effect of reducing the body's response to histamine released in response to allergic stimuli such as pollen, animal hair, or food allergens.
- Reduction of allergy symptoms: Blocking histamine receptors results in the reduction or prevention of allergy symptoms such as runny nose, itching, swelling of mucous membranes, sneezing and lacrimation. Erius is usually effective in reducing these symptoms.
- Minimal side effects: Desloratadine is highly selective for H1 receptors and has a lower tendency to cross the blood-brain barrier, making it less likely to cause drowsiness and other side effects often associated with older antihistamines.
- Long-acting: Erius has a long-lasting effect and is usually taken once a day. This makes it convenient to use and provides long-lasting protection against allergy symptoms for up to 24 hours.
Pharmacokinetics
- Absorption: Desloratadine is rapidly and completely absorbed from the gastrointestinal tract after oral administration. Food may slightly slow its absorption, but this usually does not affect its effectiveness.
- Distribution: Desloratadine is well distributed to organs and tissues, including skin, respiratory tract and eyes. It also penetrates the placental barrier and is excreted in mother's milk.
- Metabolism: Desloratadine is metabolized in the liver to form the active metabolite 3-hydroxydesloratadine. This metabolite also has antihistamine action.
- Excretion: Approximately 85% of the desloratadine dose is excreted from the body via the kidneys, mainly as metabolites, and the remainder via the intestine.
- Concentration: Maximum blood concentrations of desloratadine are usually reached 3 hours after oral administration. Its metabolites reach maximum concentrations after 8-10 hours.
- Pharmacodynamics: Desloratadine is a selective histamine H1-receptor antagonist that blocks the action of histamine, reducing the symptoms of allergic reactions.
- Duration of action: The effect of desloratadine usually lasts up to 24 hours, allowing it to be taken once daily.
- Interactions with other drugs: Desloratadine does not usually interact with other drugs, but caution should be exercised when taking it concomitantly with other drugs that may also cause sedation or enhance the effects of antihistamines.
Dosing and administration
-
Pills:
- For adults and children aged 12 years and older, it is generally recommended to take 1 tablet (5 mg desloratadine) once daily.
- The tablet is best taken with water, regardless of food intake.
-
Syrup:
- For children 6 months to 5 years of age, the dosage is usually 2.5 mL of syrup (1.25 mg of desloratadine) once daily.
- For children aged 6 to 11 years, 5 ml of syrup (2.5 mg of desloratadine) once daily is recommended.
- The syrup is best taken with a measuring spoon or syringe, which often comes with the medication.
Use Eriusa during pregnancy
According to the FDA (U.S. Food and Drug Administration), Erius is a Category C classification for use during pregnancy. This means that although studies in humans have not shown direct harm to the fetus, there is some evidence of harmful effects in animals, or there are no studies in humans or animals.
Doctors usually avoid prescribing medications during pregnancy, especially in the first trimester if possible. However, if allergy symptoms make life significantly more difficult for the pregnant woman and exceed the potential risks to the fetus, the doctor may decide to prescribe Erius. The decision is always made on an individual basis, taking into account the benefits of treatment and the possible risks.
Contraindications
- Hypersensitivity: Patients with known hypersensitivity to desloratadine or other ingredients of the drug should avoid its use because of the risk of allergic reactions.
- Pregnancy and breastfeeding: Use of Erius during pregnancy or breastfeeding requires caution and medical advice. Although desloratadine is considered relatively safe, data on its safety during pregnancy are limited, so use should be made only for medical reasons.
- Severe renal impairment: Dose adjustment is recommended in patients with severe renal impairment, as desloratadine and its metabolites may accumulate in the body.
- Hepatic insufficiency: In the presence of severe hepatic insufficiency, a dose adjustment of desloratadine may also be necessary.
- Pediatric age: The use of Erius is not recommended in children under 12 years of age, unless the benefits of treatment exceed the potential risks and the decision is made by a doctor.
- Therapy with ketoconazole or erythromycin: The use of desloratadine together with ketoconazole or erythromycin may increase the concentration of desloratadine in the blood, therefore in such cases it is recommended to take lower doses.
- Diabetes mellitus: Patients with diabetes should take Erius with caution, as the syrup contains sugar and the tablets may affect blood glucose levels.
Side effects Eriusa
- Drowsiness: In some people, taking desloratadine, the active ingredient in Erius, may cause drowsiness or tiredness. This is especially likely when using the drug for the first time or when the dose is increased.
- Dizziness: Some patients may experience dizziness while taking Erius.
- Dry mouth: This is one of the most common side effects of Erius.
- Stomach pain or diarrhea: Some people may experience stomach pain, discomfort, or diarrhea.
- Headache: Erius may cause headache in some patients.
- Inability to sleep: The drug may cause insomnia or sleep disturbance in some people.
- Throat or chest discomfort: This is a rare side effect, but some patients may experience throat or chest discomfort.
- Rare allergic reactions: In rare cases, allergic reactions such as skin rash, itching, swelling of the face or throat, difficulty breathing and anaphylaxis may develop.
Overdose
- Drowsiness and fatigue.
- Dizziness and decreased concentration.
- Dry mouth.
- Increased heart rate (tachycardia).
- Stomach disorders such as nausea, vomiting, or diarrhea.
- Rarely, more serious reactions such as bradycardia (slowing of the heart rate), hypertension, and arrhythmias may occur.
Treatment of Erius overdose usually includes symptomatic therapy aimed at relieving the manifestations of overdose. This may include gastric lavage, administration of activated charcoal to bind the drug in the stomach and reduce its absorption, and symptomatic treatment tailored to the manifestations of overdose.
Interactions with other drugs
- Cytochrome P450 inhibitors: Some drugs, such as ketoconazole, erythromycin and clarithromycin, are inhibitors of cytochrome P450 isoenzymes, which may increase the blood concentration of desloratadine and increase its effect.
- Symptomatic allergy treatment: When desloratadine is co-administered with other antihistamines, such as fexofenadine or cetirizine, increased sedation may occur.
- Alcohol: Concomitant use of alcohol with desloratadine may increase the sedative effect, resulting in impaired cognitive function and reaction time.
- Sibutramine: The use of desloratadine with sibutramine, used to treat obesity, may increase the risk of cardiac arrhythmias due to their mutual effect on the QT interval.
- Centrally acting drugs: When taking desloratadine concomitantly with other drugs that also have a central effect (e.g. Sleeping pills, antidepressants), sedation and decreased concentration may increase.
- Calcium, aluminum, magnesium containing drugs: These drugs may reduce the absorption of desloratadine from the GI tract, so they should be taken at intervals.
Storage conditions
Erius (desloratadine) should generally be stored according to the manufacturer's recommendations and standards for storage of medicines. Common storage conditions for Erius include:
- Temperature: The drug should be stored at room temperature, which is usually between 20 and 25 degrees Celsius (68 to 77 degrees Fahrenheit).
- Humidity: Erius should be stored in a dry place to prevent decomposition or aggregation of the drug. If possible, contact with water or moisture should be avoided.
- Light: The drug should be protected from direct sunlight and other sources of bright light. It is recommended to store Erius in the original package or container to minimize its exposure to light.
- Packaging: It is important to follow the instructions on the drug package regarding storage. Usually, the drug should be stored in its original packaging to maintain its stability and protect it from external factors.
- Additional information: Some manufacturers may provide additional storage recommendations. It is important to read the information on the package carefully or contact your pharmacist if you have any questions about storage conditions.
Attention!
To simplify the perception of information, this instruction for use of the drug " Erius" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.