Emoxipine

Emoxipine is an angioprotector that strengthens the strength of vascular membranes, accelerating free-radical processes. The drug is also included in the category of antihypoxants and antioxidants.

[1], [2], [3], [4]

Indications of the emoxipine

Drops for the eyes are used for such violations:

• occurring inside the eye hemorrhage;
• formed inside the central vein of the ocular retina, as well as its branches thrombosis;
• glaucoma;
• to protect the retina after the procedure of laser coagulation, and in addition to high-intensity light (for burns caused by laser or sunlight).

Use of medication in the form of injections:

• diabetic retinopathy;
• myopathy with complications;
• chorioretinal forms of central type of dystrophy.

Along with this, injections can be administered in acute or chronic forms of cerebro-vascular circulatory disorders (provided that they have arisen because of ischemic or hemorrhagic disorders). If necessary, the drug can be administered in / m way or intravenously.

[5], [6], [7], [8]

Release form

The release of the drug occurs in the form of a solution, in ampoules, having a different dosage. Within each individual pack of medicines there are 5 such ampoules, the dose size of which is indicated on the box.

Also produced in the form of eye drops - in bottles with a capacity of 5 ml, equipped with a pipette.

[9]

Pharmacodynamics

The drug reduces the blood viscosity, weakens the tendency to hemorrhage, and also strengthens the vascular membranes. At the same time, the active elements of the drug increase the parameters of cyclic nucleotides contained within the cerebrospinal tissues and blood platelets.

The fibrinolytic effect of drugs is manifested in the fact that when the infarct is exacerbated, its use promotes the expansion of coronary vessels, which allows to limit the size of the site on which necrosis develops. Together with this, the contractile and conduction functions of the heart are improved.

In the form of an ophthalmic element, the drug has a retinoprotective effect, protecting the retina from light rays of high intensity. Thanks to drops, the hemorrhages that occur inside the eye dissolve, and microcirculation processes also improve.

Medication has a positive effect on blood circulation - reducing the total coagulation index and the process of platelet aggregation, Emoxipin prolongs the period of blood circulation. Cellular and vascular membranes stabilize under the influence of drugs, erythrocytes increase their resistance to hemolysis and possible mechanical damage.

The drug helps to effectively slow the free radical processes of lipid oxidation inside the biomembranes. Also increases the activity of enzymes that provide antioxidant effects, and has a hypolipidemic effect by reducing the binding of triglycerides.

Due to the use of the drug, the symptoms of cerebral hemodysfunction are reduced. It also positively influences the resistance of the cerebral cortex in relation to hypoxia with ischemia, and also corrects the vegetative dysfunction occurring in circulatory disorders in the brain.

The drug has pronounced cardioprotective properties. Provides protection of the SSS for myocardial damage, which is ischemic: the drug blocks the spread of the lesion.

Pharmacokinetics

With intravenous injection of drugs in a dose of 10 mg / kg, an extremely low level of semi-elimination of the substance is observed. The elimination constant is 0.041 minutes. The size of the apparent distribution volume is 5.2 liters, and the level of total clearance is 214.8 ml / minute.

Emoksipin quickly passes inside the tissues with the organs in which metabolic processes are carried out.

Its pharmacokinetic parameters vary with the patient's condition taken into account. For example, with coronary occlusion, which has a painful shape, the rate of excretion of the drug decreases, which increases its bioavailability.

When administered by the retrobulbar method, the active components of the drug are almost immediately noted inside the blood, stably stored in large amounts for 2 hours. But after 24 hours after use, there are almost no traces of the presence of drugs inside the blood. Certain indicators of the drug persist inside the eye tissues.

[10], [11]

Dosing and administration

Scheme of drug administration in the form of drops.

In the retrobulbar method of drug administration, a 1% solution should be used in a 0.5 ml dose - it is administered once daily for 10-15 days. When using the solution with parabulbar or subconjunctival method, 0.2-0.5 ml of the substance are injected once a day, during 10-30 days.

If you want to protect the retina, you should inject the drug with a retrobulbar method in a dose of 0.5 ml / day 60 minutes before the procedure of laser coagulation. The duration of therapy is determined by the severity of the burns that occurred during laserocoagulation. Often drops are used once a day for 2-10 days.

Application of the drug as an injection liquid.

For neurological and cardiac disorders, medication is usually given intravenously via a dropper - at a rate of 20-40 drops / minute. Serving size - 20-30 ml of 3% substance. To put the dropper is allowed 1-3 times / day for 5-15 days. The duration of such a course is determined by the form of pathology.

After the end of the drip-drop, the patient is transferred to injections intramuscularly - 3-5 ml of a 3% solution, which is administered 2-3 times / day. The course of injection of injections in / m method lasts 10-30 days.

[14], [15], [16]

Use of the emoxipine during pregnancy

Prescribe Emoksipin pregnant is prohibited.

Contraindications

Contraindication is the presence of hypersensitivity to the elements of the therapeutic agent.

Caution should be given to breastfeeding mothers (only if there are indications).

Side effects of the emoxipine

The use of the drug may cause some side-effects: a feeling of excitement, which is replaced quickly enough by a feeling of drowsiness. Also, rashes may appear and the blood pressure level may increase. Local symptoms - pain, burning, itching, redness and denseness in the area of paraorbital tissues.

[12], [13]

Overdose

When the medicine is poisoned, the development of the reactions indicated among the side symptoms or their amplification is noted. As a result of an overdose, there may be an increase in the level of blood pressure, the development of a strong excitability or sensation of drowsiness, and in addition the appearance of headaches or pain in the heart, nausea and abdominal discomfort. Also, the process of blood uptake can be violated.

To eliminate violations, you should abolish the use of drugs, and then, if necessary, carry out symptomatic procedures.

[17]

Interactions with other drugs

When used with α-tocopherol acetate, the antioxidant effect of Emoxipine may be enhanced.

[18], [19], [20]

Storage conditions

Emoxipine should be kept in a dark place. Temperature values are not higher than 25 ° C.

[21], [22]

Shelf life

Emoxipine is allowed to be used for 3 years from the date of manufacture of the drug.

[23],

Application for children

Use the drug to appoint adolescents and children under 18 years of age is prohibited, because the data on its use in this group of patients is too small.

[24]

Analogues

Analogues of the drug are such drugs as Emoxibel with Emoxi-Optik, and besides this, Emoxipin-AKOS and Methyl ethylpyridinol-Eskom.

Reviews

Emoxipine has a high efficacy of drug treatment. The only drawback of the drug is the development of a strong local irritation when it is applied. Patients treated with severe ophthalmologic pathologies respond very positively to the drug, because because of the severity of the disease they have to use it, strictly following the instructions and recommendations of the doctor, and also because they have no choice but to use it, regardless of irritation . But in case of its use in less complicated disorders, reviews about the drops are already characterized by variability: this is due to the fact that not every patient is ready to suffer the burning sensation that occurs after the use of drugs.

Doctors speak about the drops exceptionally positively. The medication perfectly eliminates disturbances, although it leads to temporary discomfort in the treated.

The injections of the drug can cope well with the effects of heart attacks, as well as strokes. Together with this medication helps to quickly reduce the severity of the symptoms of various neurological disorders. That is why the medicine receives a large number of positive responses from both patients and doctors.

[25], [26]