Eiconol

One of the representatives of hypocholesterolemic and hypotriglyceridemic drugs that are used in pathologies of the cardiovascular system is Eikonol - a natural and effective hypolipidemic agent.

[ 1 ], [ 2 ]

Indications Eiconol

Eikonal is taken:

As a secondary prevention of myocardial infarction (usually in combination with statins, antithrombotic drugs, β-blockers, ACE inhibitors;

For endogenous hypertriglyceridemia (type 4 according to Fredrickson classification) – as an independent therapy against the background of dietary nutrition;

In case of hyperlipidemia of mixed etiology (types III and II-b) simultaneously with the use of statins;

As a preventive measure and in complex therapy for coronary heart disease, and for preventing sudden death in individuals with coronary heart disease or hypertension.

[ 3 ]

Release form

Eikonoll is produced in the form of soft oval capsules with a gelatin shell. The capsules have a yellowish-brown tint, a transparent elastic structure with a visible connecting seam. Inside the capsule there is an oily homogeneous liquid of yellow color, with an oily pleasant aroma. During long-term storage, the contents of the capsule may become slightly cloudy - this indicates the appearance of a small sediment.

The blister plate contains 10 capsules of the drug. The general cardboard packaging contains five blister plates.

Eikonal is available in pharmacies without a prescription.

[ 4 ], [ 5 ], [ 6 ]

Pharmacodynamics

The action of Eikonal is due to the rich composition of the drug - a combination of saturated and unsaturated Omega-3 fatty acids, vitamin A and vitamin D.

Eikonolum has anti-atherosclerotic, hypolipidemic and antiplatelet properties.

The hypolipidemic property is explained by the ability to normalize the structure and composition of low and very low density lipoproteins.

Eikonolum provokes changes in the properties of cell membranes and activation of membrane receptors, which has a positive effect on cell-lipid interaction. At the same time, the production of triglycerides in the liver is inhibited (by inhibiting the esterification of fatty acids). The decrease in triglyceride levels also occurs due to a decrease in the content of free fatty acids, which are intended for their release. As a result, hyperlipidemia is eliminated and atherosclerotic processes are inhibited.

The increase in HDL levels is inconsistent and small, especially compared with fibrates.

The duration of the hypolipidemic effect (after a year of treatment with the drug) is unknown. There are few arguments regarding the reduction in the risk of developing coronary heart disease.

The antiplatelet effect of Eikonal is due to changes in the lipid composition of red blood cell membranes, a decrease in the amount of arachidonic acid in them, and an increase in the amount of eicosapentaenoic acid. The listed processes lead to a decrease in the production of thromboxane A² and other diunsaturated eicosanoids, which accelerate platelet aggregation and increase the production of thromboxane A³ and other eicosanoids that do not have a pro-aggregation effect.

No significant changes in clotting factors were detected.

[ 7 ], [ 8 ], [ 9 ]

Pharmacokinetics

After taking the Eikonal capsule, the absorption of the components of the drug can occur in three ways:

• delivery of fatty acids to the liver, with inclusion in the composition of lipoproteins and redirection to the peripheral accumulation of lipids;
• replacement of cell membrane phospholipids with lipoprotein phospholipids (after which fatty acids become precursors of all kinds of eicosanoids);
• oxidation of most fatty acids to provide energy to the body.

The content of Omega-3 fatty acids in plasma phospholipids coincides with the content of fatty acids in the composition of cell membranes.

Dosing and administration

Eikonal capsules are intended for internal use. The drug should be washed down with water or juice (preferably tomato). The daily amount of the drug can be taken at one time or 2-3 times, preferably in the morning and half an hour after lunch.

If Eikonal is used for medicinal purposes, then adult patients and children from 14 years of age take 8 to 12 capsules daily. Children aged 2-14 years take 4 to 6 capsules daily. The therapeutic course lasts on average 4-8 weeks, depending on the doctor's prescription.

If Eikonal is used for prevention, it is enough to take 2 to 6 capsules daily for 4 weeks. The treatment can be repeated twice a year, preferably in the autumn-spring period.

In case of kidney dysfunction, there is no need to adjust the dosage of the drug.

[ 17 ]

Use Eiconol during pregnancy

Eikonal is not recommended for use by pregnant or lactating women, as certain properties of the drug have not been sufficiently studied at this time.

Contraindications

Eikonal is not prescribed or used:

• in exogenous hypertriglyceridemia (type I according to Fredrickson);
• in the acute phase of chronic cholecystitis;
• for pathologies of the liver and biliary system;
• with calculous cholecystitis;
• for hemorrhages;
• during pregnancy and breastfeeding;
• if there is a high probability of allergy to the drug;
• in hereditary pathologies of blood clotting.

[ 10 ], [ 11 ]

Side effects Eiconol

During treatment with Eikonal, the following undesirable accompanying symptoms may occur:

• reflux of stomach contents into the esophagus, belching with a fishy taste, nausea, increased gas formation, bowel disorder;
• skin rashes;
• allergy.

[ 12 ], [ 13 ], [ 14 ], [ 15 ], [ 16 ]

Overdose

Signs of overdose are side effects that manifest themselves to a greater extent. In addition, with prolonged treatment with Eikonal, the following may be observed:

• drowsiness;
• weakness;
• headaches;
• attacks of nausea and vomiting;
• leg pain associated with bone demineralization.

If such symptoms appear, the doctor will prescribe symptomatic therapy, and Eikonal will be discontinued in such cases.

Interactions with other drugs

• Eikonal and oral anticoagulants in combination with each other may lead to prolongation of the bleeding period.
• Eikonal with Warfarin requires periodic monitoring of prothrombin time.
• Eikonal should not be combined with fibrates (fibric acid derivatives).
• The action of Eikonal is enhanced by the influence of vitamins A and E, ascorbic and pantothenic acids, thiamine, pyridoxine, riboflavin, and magnesium-based medications.
• The combination of Eikonal with vitamins A and D may lead to the development of vitamin intoxication.

[ 18 ], [ 19 ], [ 20 ], [ 21 ], [ 22 ], [ 23 ]

Storage conditions

Eikonal is stored in a cool, dry place, out of reach of children. The maximum permissible storage temperature is no more than +20°C.

[ 24 ], [ 25 ]

Shelf life

Eikonal can be stored for up to 3 years.