The hormone-producing tumors of the adrenal cortex are one of the topical problems of modern endocrinology. Pathogenesis and clinical picture are due to the hyperproduction of certain steroid hormones by tumor tissue.
In most cases, they are found in the intestine in the area of the ileocecal angle and in the bronchi, while they are rarely functioning. Pancreatic carcinoid is capable of secreting virtually all peptides that are characteristic of ortho- and para- endocrine neoplasms.
Ectopic secretion of ACTH-like activity is known for many organs and tissues, including the pancreas. The clinical symptom complex is expressed by glucocorticoid hypercorticism.
The unusually severe course of duodenal ulcer in pancreatic tumors was noticed as far back as 1901, but only in 1955 this combination was isolated into an independent syndrome called ulcerogenic syndrome of ulcerative diathesis (or by the name of the authors who described it - Zollinger's syndrome Ellison).
Pancreatic peptide (PP) is secreted by F-cells of the pancreas. In general, the peptide reduces the contractile function of the gallbladder, increases the tone of the common bile duct and inhibits the endocrine function of the pancreas.
Glucagon is a tumor from the alpha-cells of the islets of Langerhans, secreting glucagon, which leads to the development of a complex symptom-complex, most often including dermatitis, diabetes, anemia and weight loss.
Tumors of the islets of Langerhans were known to morphologists as early as the beginning of the 20th century. The description of endocrine syndromes became possible only with the discovery of hormones of the pancreas and gastrointestinal tract.
It is necessary to distinguish its features in the period of acute tetanus attack and emphasize the need for supporting systematic therapy in the interictal period. To treat the hypoparathyroid crisis intravenously, 10% calcium chloride or calcium gluconate solution is administered. The dose is determined by the severity of the attack and ranges from 10 to 50 ml (usually 10-20 ml).
