Diseases of the liver and biliary tract

Alcoholic liver fibrosis

Alcoholic liver fibrosis develops in 10% of patients with chronic alcoholism. The main pathogenetic factor of alcoholic liver fibrosis is the ability of ethanol to stimulate the proliferation of connective tissue.

Alcoholic fatty hepatosis

A special and rare form of fatty hepatosis in chronic alcoholism is the Zieve syndrome. It is characterized by the fact that a pronounced fatty liver dystrophy is accompanied by hyperbilirubinemia, hypercholesterolemia, hypertriglyceridemia, hemolytic anemia.

Alcoholic adaptive hepatopathy

Alcoholic adaptive hepatopathy (hepatomegaly) is observed in 20% of patients with chronic alcoholism. This form of liver damage is characterized by hyperplasia of the endoplasmic reticulum on the background of a decrease in the activity of alcohol dehydrogenase, an increase in the amount of peroxisomes and the appearance of giant mitochondria.

Alcoholic liver disease

Alcoholic liver damage (alcoholic liver disease) - various violations of the structure and functional capacity of the liver, caused by prolonged systematic use of alcoholic beverages.

Primary sclerosing cholangitis

The causes of sclerosing cholangitis are numerous. Its outcome is progressive fibrosis and, as a consequence, disappearance inside and / or extrahepatic bile ducts. In the early stages of damage to the bile duct and hepatocyte is not so pronounced, liver failure develops later.

Dabina-Johnson syndrome: causes, symptoms, diagnosis, treatment

At the heart of the Dabin-Johnson syndrome (family chronic idiopathic jaundice with an unidentified pigment in the hepatic cells) is a congenital defect in the violation of the excretory function of hepatocytes (postmicrosomal hepatocellular jaundice).

Kriegler-Nayyar Syndrome: Causes, Symptoms, Diagnosis, Treatment

At the heart of the Kriegler-Nayar syndrome (nonhemolytic nuclear jaundice) is the complete absence in the hepatocytes of the enzyme glucuronyltransferase and the absolute inability of the liver to conjugate bilirubin (microsomal jaundice).

Gilbert's Syndrome

Gilbert syndrome is a hereditary disease and is transmitted by an autosomal dominant type. At the heart of the pathogenesis of the disease is the insufficiency in the hepatocytes of the enzyme glucuronyltransferase, which conjugates bilirubin with glucuronic acid.

Rotor Syndrome: causes, symptoms, diagnosis, treatment

Rotor Syndrome (chronic family non-hemolytic jaundice with conjugated hyperbilirubinemia and normal liver histology without unidentified pigment in hepatocytes) is hereditary in nature, transmitted autosomally recessively. The pathogenesis of the Rotor syndrome is similar to the pathogenesis of the Dabin-Johnson syndrome, but the defect in the excretion of bilirubin is less pronounced.

Secondary biliary cirrhosis

Secondary biliary cirrhosis of the liver is a cirrhosis that develops as a result of a prolonged disturbance of the outflow of bile at the level of the large vnucrohepatic bile ducts.

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