Some types of autoimmune hepatitis do not have a clearly established cause, others are associated with known agents such as thienyl acid (diuretic) or with diseases such as hepatitis C and D. In general, in autoimmune hepatitis of unknown etiology, there is a more vivid clinical picture for him a higher activity of serum transaminases and a level of y-globulin is characteristic; histological changes in liver tissue indicate a higher activity than in cases with known etiology, and the response to corticosteroid therapy is better.