Diclofen

Diclogene exhibits potent anti-inflammatory and analgesic activity. Antipyretic effect of drugs is expressed rather weakly.

The influence of the drug leads to the suppression of the binding processes of proteoglycans inside the cartilage. Because of this, it is effective in joint diseases and in periods after getting injuries or operations. The drug eliminates puffiness and joint stiffness, and also increases motor volume.

Prolonged use of drugs leads to desensitizing activity.

When ophthalmic or ENT procedures are prescribed to eliminate pain and swelling.

[1], [2],

Indications Diclofen

It is used for articular pathologies such as gout, ankylosing spondylitis, rheumatoid arthritis and osteoarthritis. The drug is used in the case of diseases of the musculoskeletal system (post-traumatic, degenerative or chronic) - sprains, osteochondrosis, bruises and periarthropathy.

Diclogen shows efficacy in the case of neuralgia, colic, migraine, adnexitis, proctitis, pain of various origins, developing in the zone of muscles, joints, ENT system and the spine, as well as in postoperative pain.

The medication can be prescribed to prevent miosis during ophthalmologic operations associated with cataract or macular edema of cystoid character after the removal or implantation of the lens, as well as in the case of inflammation that occurs when the eye is injured (penetrating or not). The drug should be used for ophthalmic pathologies with inflammatory and non-infectious etiology.

[3], [4], [5]

Release form

The release of drugs is implemented in the form of a gel, tablets, and parenteral fluid.

Tablets with a volume of 50 mg, 10 pieces each in a cellular package. The pack contains 5 such packages. Also, tablets with an extended type of exposure (volume 0.1 g), in the amount of 10 pieces inside the strip. In the box - 1 or 2 such strips.

It is also available as a 1% or 5% gel, inside tubes with a capacity of 20, 30, as well as 50 or 100 g. In a pack - 1 such tube.

It is also produced as a parenteral liquid (volume 25 mg / ml), inside ampoules with a capacity of 3 ml. In the box - 5 or 10 of these ampoules.

[6], [7]

Pharmacodynamics

Diclofenac, which is a substance of NSAIDs, inhibits the binding processes of COX, the main factor involved in the exchange of arachidonic acid. By preventing GHG production, the medication reduces inflammation, eliminates pain and helps reduce temperature.

[8], [9], [10],

Dosing and administration

Tablets should be taken orally - after a meal at a dosage of 25-50 mg 2-3 times a day. The duration of therapy is determined by the severity of the disease, as well as the condition of the patient. Tablets having a prolonged effect are applied 1 st (0.1 g) 1 time per day, before meals.

Parenteral fluid is administered intramuscularly or intravenously. In / in the introduction is made through an IV (the substance from the ampoule is pre-dissolved in 5% glucose or saline (0.1-0.5 l), adding 8.4% (0.5 ml) or 4.2% (1 ml) sodium bicarbonate liquid). The duration of such an infusion can be 0.5-3 hours. Parenteral administration of Diclogen is possible for a maximum of 2 days.

To prevent postoperative complications, it is required to inject 25-50 mg of the drug intravenously - 15-60 minutes before the operation. Next, infusion is performed at a speed of 5 mg / hour before the introduction of the daily maximum (0.15 g).

To remove the pain, you need to inject the medicine intramuscularly, in portions of 25-50 mg, 1-2 times a day.

For the day, children can be administered parenterally and orally not more than 2 mg / kg of the drug; in the case of juvenile arthritis, not more than 3 mg / kg, and for an adult - a maximum of 0.15 g.

Gel is necessary to treat the area where the pain is localized. The drug is applied to the washed dry skin, with neat massaging movements, 2 times a day. Children 6-12 years of age per day can use a maximum of 1 g of the substance, and adolescents from 12 years old - 2 g. If the result is absent after 14 days of application of the gel, you should consult a doctor.

[16], [17], [18], [19],

Use Diclofen during pregnancy

The drug is used during lactation or pregnancy in situations where the likely benefit to a woman is significantly higher than the risks of negative consequences for the fetus or baby. Gel can not be assigned to the 3rd trimester.

[11], [12], [13], [14]

Contraindications

The main contraindications:

• exacerbation of chronic activity of the diseases of the ulcerative-erosive nature in the area of the digestive tract;
• disorders of hematopoietic processes;
• "Aspirin triad";
• use in persons with intolerance to the elements of the drug or other NSAIDs.

Gel can not handle damaged areas of the epidermis.

Caution is required when prescribing people with porphyria, a tendency to bleeding, insufficiency of the liver or kidney function, heart failure and asthma, as well as older people.

[15],

Side effects Diclofen

Medication in the form of a gel can lead to contact dermatitis, eczema, generalized epidermal eruptions, photophobia and allergies (bronchial spasms, angioedema and urticaria).

In the case of parenteral or oral use, anemia, irritability, upset stool and digestion, epidermal itching, hypertension, nausea, headaches and severe fatigue may occur. In addition, alopecia, pancreatitis, dry oral mucous membranes, stomatitis aphthous varieties and glossitis, as well as weakening of memory, insomnia, ear noise, nightmares and dizziness. In addition, there may be pain in the area of the sternum or abdomen, platelet or leukopenia, palpitations, agranulocytosis, necrosis of the papillae of the kidneys, cystitis, hematuria, and tubulo-interstitial nephritis.

Occasionally, with the use of drugs, anorexia, ultrafast hepatitis, an ulcer or bleeding inside the gastrointestinal tract, proteinuria, hepatic pathology, diplopia, taste disorder and visual impairment may occur with hearing. At the same time, it is possible to develop anxiety, arrhythmias, convulsions, paresthesias, disorientation, oliguria, depression, allergies and tremors, as well as ARF, aseptic meningitis, nephrotic syndrome, scotomas and erythrodermia.

Puffiness of the extremities, IEE, TEN, bronchial spasms and sexual dysfunction in men are observed individually.

Overdose

When digoxin intoxication, pain occurs in the epigastric zone, ear noise, dizziness, convulsions, gastrointestinal bleeding, stool disorders, respiratory depression, lethargy, liver failure or acute renal failure, as well as a comatose state.

[20], [21], [22], [23]

Interactions with other drugs

The use of the gel together with other local substances that enhance the sensitivity of the epidermis, increases the likelihood of photosensitization.

Tablets and drug solution can increase blood levels of digoxin with cyclosporine and lithium drugs when combined with them.

There is an increase in the likelihood of negative signs and bleeding in the gastrointestinal area when the drug is combined with the rest of NSAIDs, methotrexate, St. John's wort, GCS, corticotropin, alcoholic beverages and colchicine.

The combination with substances of gold, cyclosporine, a diuretic of potassium-saving type or paracetamol leads to an increase in Diclogen's toxic activity towards the kidneys, and also the risk of hyperkalemia.

The drug weakens the medical properties of diuretic drugs, antihypertensive drugs, hypnotics and vasodilators.

Increased likelihood of bleeding occurs when sharing the drug with substances that affect the blood coagulability - thrombolytics or anticoagulants.

Drug activity of diclofenac is weakened when combined with aspirin.

The use of medication together with hypoglycemic agents for oral administration can provoke hypo-or hyperglycemia.

The risk of hypoprothrombinemia is increased in the case of a combination of the drug with valproic acid, cefoperazone, cefotetan, and plicamycin or cefamandol.

[24], [25]

Storage conditions

Diclogen is required to be kept at the standard temperature for medicines. Opened vial should be used immediately, it is forbidden to store it.

[26], [27], [28], [29],

Shelf life

Diclogene can be applied within a 3-year term from the date the drug was manufactured.

[30], [31], [32],

Application for children

Diclogene is forbidden to use in children under 6 years of age. Tablets with extended type of exposure is not prescribed until the 18th anniversary.

[33], [34], [35], [36]

Analogs

Analogues of the drug are Dicloberl, Diclo-F, Flotak, Artrex with Veral, Diclorium with Diclac, and in addition Diclomelane, Veral and Diclobene with Sodium Diclofenac and Diclonac with Dicloran. In addition, the list of Voltaren, Diclofenacol, Ortofleks, Diklovit and Diclofen with Poplar, Dyslomax, Daklofen, Dyklonat, Sanfinak with Dov, and Diclofenac, Ortofen, Remetan and Diclofenaclong, Revmavak, Dorsan is a part of the same, and the same year, Dorzan, ortofen, Remetan and Diclofenaklong, Revmavak, Dosan is a part of the same, and Dorsen is the same. SwissDzhetom and Revodinaretardom.

[37], [38], [39], [40],