Diamond Green

Brilliant green is an antiseptic that is widely used in medical practice to disinfect the skin and mucous membranes. It belongs to the class of organic dyes and has a bright green color.

Brilliant green has antimicrobial properties and can be used to treat and prevent skin infections, burns, wounds, cracks, as well as for treating injection sites and medical procedures.

It is also sometimes used to stain tissue for medical procedures such as cytology and histology.

Besides medical purposes, brilliant green can also be used in other industries, such as biology and microbiology as a dye for microscopic studies.

Please remember, however, that the use of Brilliant Green should be limited to medical purposes and should only be used as directed by a physician or other qualified health care professional.

Indications Brilliant green

1. Wound and Burn Disinfection: Brilliant Green can be used to treat the surface of wounds and burns to prevent infection and promote healing.
2. Treatment of purulent skin infections: Used to treat purulent skin infections such as boils, abscesses and others.
3. Surgery Wound Treatment: Used to disinfect surgical and injection sites to prevent infection and promote healing.
4. Treatment of injection sites: Used to treat the skin before injections to prevent infection.
5. Tissue staining in medical procedures: Brilliant green can be used in surgery, cytology and histology to stain tissue and facilitate visualization of cells and structures for microscopic examination.
6. Treatment of certain skin diseases: In some cases, brilliant green can be used in the complex treatment of skin diseases such as eczema or fungal infections.

Release form

1. Solution for external use: Brilliant green can be presented as a solution in water or alcohol. This solution can be used to treat wounds, burns, for antiseptic procedures, etc.
2. Crystalline Powder: This is a pure form of brilliant green that can be diluted in water or other solvents for various purposes.

Pharmacodynamics

1. Antiseptic: Brilliant Green has antimicrobial properties and can kill or inhibit the growth of bacteria, fungi and viruses. It is often used to treat and prevent infections on the skin and mucous membranes.
2. Antimicrobial effect: Brilliant green can penetrate microorganisms and disrupt their cellular structures, which leads to their death.
3. Antifungal: It may be effective against fungal infections of the skin and mucous membranes.
4. Colouring Effect: Brilliant Green has a vibrant green color and can be used as a dye to visually mark treated areas.
5. Toxicity: High concentrations of Brilliant Green may be toxic to the body, so it should be used carefully and as recommended by a physician.
6. Use in the treatment of wounds and burns: Brilliant green can be used to treat superficial wounds, burns, abrasions and other skin lesions.
7. Medical Diagnostic Applications: Brilliant Green is sometimes used in medical procedures to visualize and diagnose various conditions, such as testing the permeability of lymphatic vessels.

Pharmacokinetics

1. Absorption: When applied topically to the skin or mucous membranes, Brilliant Green can be absorbed into the systemic circulation. However, absorption is usually negligible.
2. Distribution: Once absorbed, brilliant green can be distributed into body tissues. It can accumulate in the liver and be excreted through bile.
3. Metabolism: Diamond Green is not typically metabolized by the body.
4. Excretion: Diamond Green is excreted from the body primarily through bile and then through the intestines. Small amounts may also be excreted through urine.
5. Half-life: The half-life of Brilliant Green may vary depending on individual characteristics and dosage, but is usually several hours.

Dosing and administration

1. For treating wounds and burns:

   • Usually brilliant green is used in the form of a solution for external use.
   • Wounds are treated, washed or coated with a solution of brilliant green.
   • To do this, you can use a diluted solution or soak a gas bandage and apply to the wound.

2. For the treatment of skin infections:

   • Brilliant Green can be applied to the skin to treat infections such as fungal infections or simple wounds.
   • Usually the solution is applied to the area of infection using a cotton swab or applicator.

3. In laboratory studies:

   • In microbiology and histology, brilliant green is used to stain tissues and cells.
   • Dosage and method of application depend on the specific staining protocol and type of sample.

Use Brilliant green during pregnancy

Use of Brilliant Green during pregnancy should be considered with caution. There is currently limited data on the safety of its use in pregnant women, so it is recommended to use it only in cases where it is truly necessary and recommended by a doctor. It is important to consider the following points:

1. Absorption and toxicity:

   • Although Brilliant Green is used topically, there is a small risk of systemic absorption, especially if applied to large areas of skin or open wounds. In such cases, a potential risk to the developing fetus can be assumed.

2. Alternative means:

   • Less aggressive antiseptics, such as chlorhexidine or povidone-iodine, may be preferable for skin care during pregnancy if approved by your physician.

3. Consultation with a doctor:

   • Before using Brilliant Green or any other drug during pregnancy, it is important to consult with your doctor who can evaluate the potential risks and benefits of its use in your particular case.

Contraindications

1. Individual intolerance or allergic reaction: Some people may experience an allergic reaction to brilliant green, which manifests itself in the form of itching, redness, rashes and even angioedema. Therefore, if you experience such reactions, you should stop using the drug and consult a doctor.
2. Broken Skin: Brilliant Green is not recommended for use on open wounds, cuts or severely damaged skin as it may cause irritation and aggravate the condition.
3. Age: Brilliant Green may be less safe for use in infants or young children, so it is recommended that you consult a doctor before using it in children.
4. Pregnancy and Breastfeeding: If using Brilliant Green during pregnancy or breastfeeding, consult your doctor to evaluate the potential risks and benefits.
5. Avoid contact with eyes and mucous membranes: Diamond Green should not come into contact with eyes or mucous membranes, as this may cause irritation and burns.
6. Prolonged Use: Prolonged and excessive use of Brilliant Green may cause dryness and irritation of the skin.

Side effects Brilliant green

1. Allergic reactions:

   • Some people may experience allergic reactions to brilliant green, which include skin rashes, itching, hives, and even swelling.

2. Skin irritation:

   • Use of Brilliant Green may cause local skin irritation, redness or burning, especially if the skin is sensitive or if the product is used in large quantities.

3. Skin spots:

   • Brilliant Green leaves green stains on skin and fabrics that can be difficult to clean. Although this is not a side effect in the traditional sense, it can cause inconvenience.

4. Toxic reactions:

   • When used over large areas of skin or on open wounds, there is a risk of systemic toxicity, especially in infants and young children who have a higher risk of absorption through the skin.

5. Photosensitization:

   • Brilliant Green may increase skin sensitivity to sunlight, potentially leading to photodermatitis upon sun exposure.

Overdose

1. Toxic reactions: Toxic reactions such as nausea, vomiting, abdominal pain and diarrhea may occur if consumed orally or if large doses are ingested.
2. Allergic Reactions: Some people may develop an allergic reaction to brilliant green, resulting in itching, skin rash, swelling, or angioedema.
3. Methemoglobinemia: Ingesting large amounts of Brilliant Green may cause methemoglobinemia, a condition in which the level of methemoglobin in the blood increases, which can lead to headaches, dizziness, cardiac arrhythmias and fainting.
4. Toxic effects on the kidneys and liver: Toxic effects on the kidneys and liver may occur with prolonged or excessive exposure to brilliant green.
5. Other systemic complications: Various other systemic complications are possible, including cardiovascular, respiratory, and nervous system disorders.

Interactions with other drugs

1. Heart medications: Brilliant green may interact with some medications used to treat heart conditions. For example, it may interact with the metabolism of nitrates and angioprotectors.
2. Medicines to treat infections: In rare cases, brilliant green may interfere with the effectiveness of antibiotics, especially if it is used as an antiseptic along with antibiotics.
3. Allergy Medications: Interactions between Brilliant Green and allergy medications are usually minimal, but may occur in rare cases.
4. Skin Medications: Brilliant Green may interact with skin medications, especially if it is used as a dye or antiseptic on the skin.