Dexalgin

In diseases of the musculoskeletal system, non-steroidal anti-inflammatory drugs are actively used, of which Dexalgin is a typical representative.

Dexalgin is a medicament that refers to the derivatives of propionic acid, with the active ingredient dexketoprofen. The drug effectively eliminates joint and muscle pain, including rheumatic.

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Indications Dexalgin

Dexalgin is used for symptomatic elimination of minor or moderate painful sensations:

• with pain in muscles;
• pain in the joints;
• with painful sensations during menstruation in women;
• with toothache.

Release form

Dexalgin is a tablet having a film-coated, white coating and a dividing line on both sides.

The tablets are sealed in a blister, 10 pcs. Each. In one blister.

A cardboard package may contain one, three or five blister plates, as well as a medical instruction for the use of the medicament.

Dexalgin is referred to medicines that are dispensed in pharmacies only if prescription is confirmed by a doctor.

Pharmacodynamics

The active ingredient of the drug Dexalgin is a salt of propionic acid, which has analgesic, anti-inflammatory and antipyretic properties. The category of Dexalgine is non-steroidal anti-inflammatory drugs.

The effect of Dexalgina is explained by a decrease in the production of prostaglandins by inhibition of cyclooxygenase. For example, the transformation of arachidonic acid into cyclic endopeoxides pgg² and pgh², which promote the formation of prostaglandins pge¹, pge², pgf²ª, pgd², prostacyclin pgi² and thromboxanes txa² and txb², is blocked.

Among other things, blocking the production of prostaglandins affects other factors of the inflammatory process - for example, kinin. This can affect the basic properties of the drug. The inhibitory capacity of the active ingredient with respect to cyclo-isogenase isoenzymes was found during studies with animals and humans. During the experiments it was proved that active dexketoprofen possesses a pronounced analgesic property, which manifests itself after half an hour after the use of the drug, and lasts about 5 hours.

Pharmacokinetics

After the internal use of tablets Dexalgin the maximum content of the drug in the blood is detected after about half an hour. The time of distribution and half-life of the active ingredient can be 35 minutes and 2 hours, respectively. The connection with plasma proteins is high, about 99%.

The active ingredient dexketoprofen is excreted through the urinary system. Biological availability of the drug does not change depending on the frequency of administration of Dexalgin. The medicine does not accumulate in the tissues and fluids of the body.

The intake of tablets does not depend on food intake, however, the presence of dietary masses in the stomach lowers the indicator of the drug's limiting concentration, and also slows the rate of its absorption.

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Dosing and administration

Dexalgin is prescribed, given the intensity and severity of the pain. The standard amount of the drug is half the tablet every 4-6 hours, or the whole tablet every 8 hours. The average daily amount of the drug is no more than three 25 mg tablets.

Dexalgin should not be taken for a long time - it is a symptomatic drug that is taken only for relief of the main pain symptom.

For better effect, Dexalgin is taken half an hour before a meal.

Patients of the elderly and senile age are not recommended to take more than 2 tablets of Dexalgin daily.

For the children's age, the dosage of the drug is not determined, since taking it to children is not recommended.

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Use Dexalgin during pregnancy

Dexalgin is not used in the third trimester of pregnancy and during breast feeding of the baby.

In the first and second trimesters, the use of the drug is allowed, but only in case of acute necessity. At the same time, the dosage should be extremely low, and only a medical specialist should prescribe it.

Blocking the production of prostaglandins can adversely affect the course of pregnancy and the development of the unborn child. According to the studies, in any segment of the pregnancy period, Dexalgin can increase the risk of spontaneous interruption, as well as heart disease, gastroschisis in the fetus.

When planning pregnancy, it is also recommended to take extremely low dosages of the drug, or refuse it altogether.

In the third trimester, with the acceptance of Dexalgin, the following deviations may occur:

• cardiovascular intoxication;
• impaired renal function.

In later terms, the woman may have a longer bleeding time, even if the minimum dosage of the drug has been applied. In addition, sometimes inhibition of the contractile function of the uterus is observed, which threatens to delay the birth activity.

Information on the penetration of Dexalgin into the composition of breast milk is absent.

Contraindications

Dexalgin is not appointed:

• with hypersensitivity to the ingredients of the drug, as well as to any other non-steroidal anti-inflammatory drug;
• in the acute phase of peptic ulcer, with suspicion of gastric bleeding, with chronic dyspepsia;
• with various bleeding and syndrome of increased bleeding;
• with nonspecific ulcerative colitis, Crohn's disease;
• with bronchial asthma;
• with decompensated cardiac insufficiency;
• with insufficient renal function (if creatinine clearance is less than 50 ml per minute);
• with insufficient hepatic function;
• with various disorders of blood coagulation processes;
• in the third trimester of pregnancy and lactation.

Side effects Dexalgin

During treatment with Dexalgin, some side effects may appear:

• decrease in the number of platelets in the blood;
• allergic reactions, angioedema;
• deterioration of appetite;
• sleep disturbance, anxiety;
• pain in the head, numbness of the limbs, syncope;
• the nebula of sight;
• vertigo, ear noise;
• increased heart activity;
• increase or decrease in blood pressure;
• bronchospasm;
• dyspepsia, abdominal pain, increased gas formation, thirst, stomach ulcer and duodenal ulcer, inflammation of the pancreas;
• hepatitis;
• skin rash, hyperhidrosis;
• back pain;
• nephrotic syndrome;
• malfunctions of a monthly cycle, disturbances of function of a prostate;
• a feeling of fatigue, myasthenia gravis, a general feeling of discomfort.

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Overdose

When taking large doses of Dexalgina, there is supposedly an increase in adverse events. Disturbances of digestion, disorders from the nervous system can be observed.

In case of accidental ingestion of a large number of tablets, Dexalgin performs symptomatic treatment. Required reception activated carbon.

In severe cases, it is possible to use hemodialysis.

Interactions with other drugs

Undesirable combinations of drugs:

• Dexalgin and other non-steroidal anti-inflammatory drugs - the risk of developing a peptic ulcer increases;
• Dexalgin and anticoagulants - increased risk of bleeding;
• Dexalgin and corticosteroids - the risk of damage to the digestive tract is increased;
• Dexalgin and lithium-based medicines - toxic effects on the kidneys;
• Dexalgin and large doses of methotrexate - a toxic effect on the circulatory system;
• Dexalgin and sulfonamides - increased intoxication of the body.

With caution and under the supervision of a doctor, combinations of Dexalgin with diuretics, aminoglycosides, pentoxifylline, zidovudine, sulfonylureas, β-adrenoblockers, cyclosporine, thrombolytic agents, probenecid, cardiac glycosides, quinolines and mifepristone are used.

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Storage conditions

Dexalgin is allowed to be stored at temperatures up to + 30 ° C. Keep the drug in its original packaging, in a place inaccessible to children.

Shelf life

Dexalgin retains no more than 2 years.

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