Dermazole Plus

Dermazole plus is an antifungal drug with a local method of therapeutic effect.

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Indications Dermazole plus

The medicine is used to destroy and prevent the appearance of various fungal infections affecting the scalp, accompanied by itching and peeling:

• elimination of dandruff;
• elimination of dermatitis of a seborrheic nature;
• in the case of pityriasis versicolor, a localized form of lichen - in the hairy area of the skin on the head.

Release form

The product is released in the form of shampoo, in bottles of 50 or 100 ml. There is 1 such bottle inside the box.

Pharmacodynamics

The medicinal effect of the shampoo is developed due to the action of its active elements – zinc pyrithione with ketoconazole.

Ketoconazole is an artificial derivative of imidazole dioxalan, which has fungistatic and fungicidal properties against dermatophytes (Microsporum spp., as well as Epidermophyton spp. and trichophytons), as well as various strains of yeast-like fungi, as well as yeast-type fungi (from the genus Candida and Malassezia furfur).

Zinc pyrithione has antimicrobial and antimycotic effects when used externally. It is effective against fungi, staphylococci, streptococci and other pathogenic bacteria. This element has an antiseborrheic effect and helps eliminate dandruff along with seborrheic dermatitis.

A shampoo containing ketoconazole relieves itching and flaking, which often occur with dandruff, pityriasis versicolor and seborrheic dermatitis.

Thanks to the powder of the aloe vera plant, the hair is moisturized, and at the same time, the hair is enriched with various useful microelements, as well as vitamins.

Pharmacokinetics

No tests have been performed to determine the pharmacokinetic characteristics of the drug, but there is evidence that zinc pyrithione with ketoconazole after external application is almost not absorbed into the circulatory system and does not have a systemic effect.

Dosing and administration

Before use, shake the bottle of shampoo well.

It must be applied to pre-moistened scalp and hair for approximately 3-5 minutes, and then rinse the substance with warm water.

Schemes for using the drug for different diseases:

• for dandruff, and at the same time for seborrheic dermatitis - therapy lasts 0.5-1 month, using shampoo twice a week; for prevention, it is necessary to use the medication once a week or once every two weeks;
• for pityriasis versicolor - for treatment, you need to wash your hair with shampoo every day for 5 days; for prevention, take a single course before the start of the summer season - wash your hair with the preparation every day for 3 days.

Use Dermazole plus during pregnancy

During lactation or pregnancy, the shampoo can be used only in situations where the probable benefit to the woman is higher than the possibility of complications for the baby/fetus.

Contraindications

Contraindications include hypersensitivity to zinc pyrithione, ketoconazole or other components of the therapeutic agent.

Side effects Dermazole plus

The use of shampoo may cause the appearance of certain side effects:

• lesions affecting the subcutaneous layer and skin: itching with burning, development of erythema, contact dermatitis, acne, rashes and irritation. Also, a pustular rash appears at the treatment site, a feeling of discomfort, increased sensitivity, urticaria, and in addition, dry skin and changes in the skin develop, and peeling increases;
• disorders of the skin appendages: increased oiliness or dryness of the hair, changes in its structure or color, as well as alopecia (all these symptoms develop in people with gray or chemically damaged hair) and discoloration of the nails. There have also been reports of naturally curly hair straightening;
• disorders of the nervous system: taste disorders (dysgeusia), hypersensitivity and paresthesia;
• immune manifestations: symptoms of hypersensitivity, including anaphylactoid symptoms, and in addition, Quincke's edema;
• visual impairment: swelling of the eyelids, irritation affecting the eyes, and increased lacrimation;
• infectious and invasive processes: development of folliculitis.

Overdose

Because the drug is used exclusively externally, and ketoconazole almost does not penetrate the circulatory system, the likelihood of signs of intoxication is extremely low.

In case of accidental ingestion of the medication, only symptomatic and supportive procedures are performed. Inducing vomiting or performing gastric lavage is prohibited to avoid aspiration.

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Interactions with other drugs

If Dermazole is prescribed to people who have used topical GCS for a long time, it is necessary to continue using the latter, with gradual withdrawal over the next 2-3 weeks (to avoid the development of withdrawal syndrome).

The likelihood of interaction with other medications is extremely low, because the systemic absorption of the shampoo is very weak.

It is prohibited to combine the drug with dermatological drugs that contain GCS.

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Storage conditions

Dermazole Plus should be kept in a place closed to small children. Temperature conditions – within 25°C.

Shelf life

Dermazole Plus can be used for 3 years from the date of manufacture of the therapeutic agent.

Application for children

There is no data on the use of Dermazole Plus in children.

Analogues

The following medications are analogs of the drug: Bifon with Skin-Cap, as well as sulfur ointment, Perhotal with Ketozoral and Sulsen Forte, and in addition to this, the shampoos Nizoral, Mikozoral, Sebozol, Tsinovit, Sulsena, Friderm and Keto Plus, as well as Kenazol. This list also includes Tsinocap, Ecoderm with Sebopyrox, Nezo-Pharm, Ebersept, Friderm (tar and zinc) and Terbinakod.

Reviews

Dermazole Plus receives many positive reviews, which speak of the high effectiveness of the drug in eliminating dandruff, as well as various fungal diseases affecting the scalp.

The shampoo is mainly discussed in the context of its effectiveness against dandruff. Most patients note that although the drug is not cheap, it works very well.