Dermadrine

Dermadrin is an antipruritic drug with a local anesthetic effect. It is an antihistamine drug for topical use.

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Indications of the dermadrine

It is used to eliminate signs of itching, local pain and hypersensitivity in such cases:

• with dermatitis (also itchy or allergic type);
• due to the bites of various insects;
• with eczema or urticaria;
• for thermal type burns (this includes sunburn);
• in case of development of itching in the area of abrasions and wound edges;
• with polymorphic rash (allergies to sunlight).

Release form

Release in an ointment form in tubes with a volume of 20, 50 or 100 g. Inside a separate pack - 1 tube with ointment.

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Pharmacodynamics

Dermadrin has a blocking effect on the receptors (H1) of diphenhydramine, and also selectively inhibits H1 histamine endings.

The component of diphenhydramine hydrochloride has a pronounced anti-allergic, as well as antihistamine effect and a powerful antipruritic effect. In addition, the medicine has analgesic properties.

The ointment contains a cream component, so it does not cause irritation and is evenly applied to the skin. At the heart of the medicine is an emulsion of water-oil type, which provides a cooling effect.

Pharmacokinetics

After local treatment, the active component of Dermadrin passes inside the subcutaneous tissues and skin. Anesthetic and antipruritic effects are manifested immediately after the application of drugs and lasts for 2-6 hours.

Dosing and administration

Ointment should be treated affected areas of the skin, taking into account the area of the affected part:

• for adolescents from 12 years and adults - apply 5-15 cm of ointment 3-4 times a day;
• children aged 6-12 years - use 8-10 cm of medication 3-4 times per day;
• children 2-6 years old - 3 cm Dermadrine, 2-3 procedures per day.

During the day, adolescents from 12 years and adults can not apply more than 300 mg of active substance LS (15 grams of ointment). This figure is about ¾ tube with a medicine (volume 20 g), 1/3 tube with a volume of 50 g, and also 1/6 tube with a volume of 100 g.

Children 6-12 years old can apply a maximum of 150 mg of the active ingredient Dermadrin per day, which is 41 cm ointment strip. 

For children in the period of 2-6 years, a maximum of 37 mg of medicinal substance per day - about 10 cm of ointment strip can be used.

Weakened or elderly people, and in addition to those with liver / kidney failure in severe form, it is necessary to select the sizes of doses and the duration of the course of use, given the severity of the disease and the effectiveness of the treatment performed. All indicators are assigned individually.

In the case of prolonged use of the ointment, it is necessary to assess the need for further use of drugs.

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Use of the dermadrine during pregnancy

It is forbidden to use the medicine on the 1st trimester. According to epidemiological tests, it was found that pregnant women who used ointment in the first trimester, there was an increase in the incidence of the appearance of wolves in babies.

Animal tests have demonstrated that there is a risk of reproductive toxicity.

It is forbidden to treat with ointment large areas of the skin during pregnancy. Use Dermadrin is required after the appointment of an individual dosage size and only if the likelihood of benefit to the mother exceeds the risk of complications in the fetus. The continued use of H1 antagonists in pregnancy is often prohibited, because controlled tests have not been performed, which is why it is not possible to completely exclude the appearance of retinopathy of prematurity.

During lactation it is necessary to remember that the active component of drugs can penetrate into the mother's milk.

Contraindications

Among the contraindications:

• intolerance of the active component or additional elements of drugs, as well as other antihistamines;
• combination with other drugs, which contain the substance of diphenhydramine hydrochloride;
• treatment of areas with fractures, open wounds, and also mucous membranes and large areas of the skin (especially in cases of measles, chickenpox and vesicular skin diseases).

Side effects of the dermadrine

The composition of the ointment contains peanut butter, which occasionally can cause the development of allergies. The substance methyl parahydroxybenzoate can provoke skin irritation in an easy form. The ethyl is able to provoke the emergence of local dermatological manifestations (such as the contact form of dermatitis).

Due to violation of the regime of use, certain side effects may develop:

• dermatological diseases and subcutaneous layer reactions: cutaneous manifestations of allergy, photosensitivity (it is forbidden to be under sunlight) with pruritus and redness, the appearance of swelling and blisters, and in addition the development of dryness of the mucous membranes of the mouth;
• manifestations of the NC: in case of excessive absorption of the ointment through the skin, a feeling of fatigue develops (especially in children), increased sensitivity, a feeling of anxiety of excitability and anxiety, and spasms;
• pathology of urinary organs and kidneys: problems with the process of urination.

Interactions with other drugs

Tests for drug interaction were not performed. In the case of treatment with large areas of the skin, the likelihood of interaction can not be excluded. This applies, for example, to the use of MAOI, but in addition to drugs, which contain the substance diphenhydramine.

Tricyclics, together with atropine, are capable of potentiating the cholinolytic effect of the active component of Dermadrin, and in addition the properties of opioid analgesics, hypnotic drugs and drugs that suppress the function of the central nervous system.

Perhaps the emergence of interactions with antihypertensive drugs.

When combined with alcoholic beverages, alcohol exposure may be intensified.

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Storage conditions

Dermadrine is required to be kept in a place that is closed from penetration of sunlight, at a temperature within 15-25 ° C.

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Shelf life

Dermadrin is allowed to be used during the 3 years since the release of the ointment. At the same time after opening the tube, the expiry date is only 1 year.