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Depantol
Last reviewed: 03.07.2025
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Depantol is a combination drug with anti-inflammatory, reparative, and antimicrobial properties.
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Indications Depantol
Depantol suppositories are indicated for the treatment of patients suffering from vaginitis (acute or chronic stage), as well as exo- or endocervicitis (also with complications in the form of ectopia of the cervix).
The medicine is also used in the complex treatment of true erosive lesions of the cervix.
Suppositories can be prescribed to speed up the process of regeneration of the vaginal mucosa damaged as a result of destructive treatment methods (including diathermocoagulation, cryo-, and laser destruction), and also in the postpartum period or after gynecological operations.
Release form
It is produced in the form of suppositories. One blister contains 5 suppositories. The package contains 1-2 blister plates.
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Pharmacodynamics
The medicine contains 2 active components – chlorhexidine bigluconate and dexpanthenol.
Chlorhexidine is an antiseptic that has an active effect on a relatively large group of gram-negative and gram-positive microbes, yeast fungi, protozoa, and herpes viruses and dermatophytes. Among the strains sensitive to the substance are: vaginal trichomonas, gardnerella vaginalis, Escherichia coli, pale treponema, ureaplasma, chlamydia, staphylococci, streptococci, and also bacteroides fragilis and gonococcus. Chlorhexidine has no effect or weak effect on strains of Proteus spp. and pseudomonads, and also viruses (except for the herpes virus), spores and acid-resistant microorganisms. The substance retains its properties under the influence of pus, blood, and some secretions.
Dexpanthenol is a prodrug that is metabolized, acquiring the form of calcium pantothenate. This component is a component of coenzyme A, participates in the processes of carbohydrate and lipid metabolism, and in addition to acetylation. Along with this, it is a participant in the processes of binding of hormones GCS, acetylcholine, and in addition to porphyrins. The substance stimulates recovery processes, stabilizes cellular metabolism, strengthens collagen fibers and enhances mitosis processes.
Depantol suppositories do not affect the activity of lactobacilli.
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Dosing and administration
The medicine must be administered intravaginally. The suppository must be removed from the blister immediately before the procedure. The procedure should be performed lying on your back - the suppository should be inserted deeply. Before use, wash your hands and perform standard hygiene procedures. The dosage, as well as the duration of the therapeutic course, is prescribed by the attending physician.
As a rule, the dosage is 1 suppository 2 times a day.
On average, the treatment course lasts 7-10 days. There is a possibility of extending the treatment to 20 days - this depends on the effectiveness of the therapy, as well as the nature of the pathology.
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Use Depantol during pregnancy
The medicine is allowed to be used by pregnant and lactating women.
Contraindications
Contraindications include: the patient's intolerance to any of the components of the drug. Suppositories should also not be prescribed to children.
Side effects Depantol
Depantol is generally well tolerated, without causing various side effects. Sometimes patients experience hyperemia, itching and a burning sensation in the vaginal mucosa, as well as on the external part of the genitals. If the patient has an intolerance to the active substances of the drug, local and systemic allergic reactions may develop.
Side effects of the drug usually disappear after stopping the use of suppositories and do not require specific treatment.
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Interactions with other drugs
The medicine cannot be combined with substances that belong to the anion group, and also with soap (if these agents are administered intravaginally).
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Storage conditions
Suppositories must be stored in standard conditions for medicines at a temperature of 10-20°C.
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Shelf life
Depantol is approved for use for 2 years from the date of release of the drug.
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Attention!
To simplify the perception of information, this instruction for use of the drug "Depantol" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.