Chloropyramine hydrochloride

Chloropyramine hydrochloride has anti-cholinergic, antihistaminic, antispasmodic, and also hypnotic and at the same time antiallergic effect.

[1],

Indications of the chloropyramine hydrochloride

It is used to eliminate the following disorders:

• an allergic form of conjunctivitis;
• seasonal allergy;
• a runny nose of a vasomotor character;
• hives;
• allergy to medicines;
• angioedema;
• an easy stage of bronchial asthma;
• serum sickness;
• skin pathologies (such as atopic or contact form of dermatitis, neurodermatitis, and in addition eczema and toxicodermia);
• itching, resulting from the bite of an insect;
• respiratory pathologies of an acute nature (helps to "dry" the mucous membranes).

Release form

The release is made in tablets with a volume of 25 mg, 20 pieces inside the package.

Pharmacodynamics

The drug is reversibly synthesized with histamine (H1) conductors, while blocking them. This allows you to remove hypersecretion and swelling of the nasal mucosa, spasm of the bronchi and smooth muscles, as well as itching. In addition, there is a narrowing of the capillaries and strengthening the strength of the walls of the vessels.

Has sleeping pills, antihistamine, and also expressed antipruritic properties. The highest efficacy is demonstrated in preventing the development of allergy symptoms, as well as in reducing the severity of their symptoms.

Blocking m-holinoretseptorov leads to a moderate spasmolytic effect against smooth muscle organs - there is a decrease in muscle tone in the bronchi, intestines and urea.

[2],

Pharmacokinetics

Chloropyramine is absorbed completely, and its peak values are found inside the blood after a lapse of 2 hours. This level is held for 4-6 hours. The distribution of matter within the body is uniform.

The drug is exposed to the processes of hepatic metabolism. Excretion is carried out with feces and urine.

[3]

Dosing and administration

You should drink the drug orally - for adults, the size of the portion is 25-50 mg (3-4 meals per day). For a day is allowed to use no more than 150 mg of drugs.

Children taking into account the age should take the medicine in portions in the range of 6.25-12.5 mg, three times a day. For small children it is recommended to crush the tablet to the state of powder.

Chloropyramine is allowed to be taken to infants starting at the age of 1 month, but it can only be prescribed by a doctor in this case.

[10],

Use of the chloropyramine hydrochloride during pregnancy

It is forbidden to prescribe Chloropyramine hydrochloride to pregnant women.

Contraindications

The main contraindications:

• glaucoma of a closed angle;
• the presence of hypersensitivity to the drug;
• astheno-depressive syndrome;
• breastfeeding women;
• hyperplasia of the prostate;
• pilorospasm;
• urinary or intestinal atony;
• seizures of epilepsy;
• children in infancy.

Caution is required when using people who experience urinary retention and gastrointestinal ulcers, as well as those who use drugs that have an overwhelming effect on the central nervous system.

[4], [5], [6], [7]

Side effects of the chloropyramine hydrochloride

Taking medication can lead to the appearance of the following side effects:

• impairment of motor coordination, drowsiness, inhibition of psychomotor activity, dizziness, and worsening of attention;
• the appearance of a sensation of dryness in the nasal and oral cavity, and also in the throat;
• diarrhea, nausea, loss or increase in appetite, and development of gastralegia;
• a decrease in the values of AD, the development of tachycardia or arrhythmia.

[8], [9]

Overdose

Intoxication in a child manifests itself in the form of such symptoms: a feeling of excitement or anxiety, the appearance of convulsions, involuntary limb movements, and hallucinations. In addition, the pupil can expand, develop vascular collapse or hyperthermia.

In adults there is an excitation of a psychomotor character or a feeling of inhibition, but also a disorder of consciousness. Vascular collapse or convulsions may occur.

To eliminate the violations, gastric lavage is performed, and anticonvulsants, sorbents and caffeine are consumed. In the presence of indications, ventilation may be used.

[11], [12], [13],

Interactions with other drugs

Chloropyramine hydrochloride potentiates the properties of sedatives, as well as hypnotic drugs, anesthetics, narcotic analgesics, and atropine.

Tranquilizers and tricyclics potentiate the inhibitory effect of the chloropyramine substance against the CNS.

The drug is incompatible with ethyl alcohol.

[14], [15], [16], [17],

Storage conditions

Chloropyramine hydrochloride should be kept in a dark place at temperature values not higher than 25 ° C.

[18], [19]

Shelf life

Chloropyramine hydrochloride is allowed to be used for 2 years after the release of the drug.

[20], [21]

Reviews

Chloropyramine hydrochloride is an antihistamine drug of the 1st generation, which is reversibly synthesized with H1 conductors. Because of this, in order to obtain a therapeutic effect, the drug should be taken in large dosages, and therefore the effect of the drug has a short duration, for a day the drug should be consumed 4 times, and sometimes even 6.

The intake of large portions of the drug leads to the development of a feeling of drowsiness, as well as sedation (in some people also to dizziness). It is these facts that are usually the cause of negative reviews about the drug. Because of this impact, there is a need to limit the use of drugs in individuals whose work is associated with high coordination of movements, as well as rapid response. Therefore, doctors who prescribe this drug are required to warn patients about the possibility of developing sedative effects.

Rochloride is allowed to be used for 2 years from the date of release of the drug.