Chloropyramine hydrochloride

Chloropyramine hydrochloride has anticholinergic, antihistamine, antispasmodic, and also hypnotic and antiallergic effects.

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Indications Chloropyramine hydrochloride

It is used to eliminate the following disorders:

• allergic form of conjunctivitis;
• seasonal allergies;
• vasomotor rhinitis;
• hives;
• allergy to drugs;
• angioedema;
• mild stage of bronchial asthma;
• serum sickness;
• skin pathologies (such as atopic or contact dermatitis, neurodermatitis, and also eczema and toxicoderma);
• itching caused by the bite of some insect;
• acute respiratory pathologies (helps to “dry out” the mucous membranes).

Release form

The product is produced in tablets of 25 mg, 20 pieces per package.

Pharmacodynamics

The drug is reversibly synthesized with histamine conductors (H1), blocking them. This allows you to remove hypersecretion and swelling of the nasal mucosa, spasm of the bronchi and smooth muscles, and itching. In addition, there is a narrowing of the capillaries and strengthening of the strength of the vessel walls.

It has hypnotic, antihistamine and pronounced antipruritic properties. It demonstrates the highest efficiency in preventing the development of allergy symptoms and reducing their severity.

Blocking m-cholinergic receptors leads to a moderate antispasmodic effect on smooth muscle organs - there is a decrease in muscle tone in the bronchi, intestines and bladder.

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Pharmacokinetics

Chloropyramine is absorbed completely, and its peak levels are found in the blood after 2 hours. This level is maintained for 4-6 hours. The distribution of the substance within the body is uniform.

The drug undergoes hepatic metabolism processes. Excretion occurs with feces and urine.

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Dosing and administration

The drug should be taken orally - for adults, the serving size is 25-50 mg (3-4 doses per day). No more than 150 mg of the drug is allowed per day.

Children, depending on their age, should take the medicine in doses ranging from 6.25 to 12.5 mg, three times a day. For small children, it is recommended to crush the tablet to a powder state.

Chloropyramine is allowed to be taken by infants starting from the age of 1 month, but in this case only a doctor can prescribe it.

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Use Chloropyramine hydrochloride during pregnancy

Chloropyramine hydrochloride should not be prescribed to pregnant women.

Contraindications

Main contraindications:

• closed-angle glaucoma;
• presence of hypersensitivity to the drug;
• asthenodepressive syndrome;
• breastfeeding women;
• prostate hyperplasia;
• pylorospasm;
• urinary or intestinal atony;
• epileptic seizures;
• infants.

Caution is required when used by people who have urinary retention and ulcers in the gastrointestinal tract, as well as those who use drugs that have a depressant effect on the central nervous system.

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Side effects Chloropyramine hydrochloride

Taking the medication may cause the following side effects:

• impaired motor coordination, feeling of drowsiness, inhibition of psychomotor activity, dizziness, and also deterioration of attention;
• the appearance of a feeling of dryness in the nasal and oral cavity, as well as in the throat;
• diarrhea, nausea, loss or increase in appetite, as well as the development of gastralgia;
• decrease in blood pressure values, development of tachycardia or arrhythmia.

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Overdose

Intoxication in a child manifests itself in the form of the following symptoms: a feeling of excitement or anxiety, the appearance of convulsions, involuntary movements of the limbs, and hallucinations. In addition, the pupil may dilate, vascular collapse or hyperthermia may develop.

In adults, there is agitation of a psychomotor nature or a feeling of inhibition, and in addition, a disorder of consciousness. Vascular collapse or convulsions may occur.

To eliminate the disorders, gastric lavage is performed, anticonvulsants, sorbents and caffeine are used. If indicated, artificial ventilation can be used.

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Interactions with other drugs

Chloropyramine hydrochloride potentiates the properties of sedatives, as well as sleeping pills, anesthetics, narcotic analgesics, and atropine.

Tranquilizers and tricyclics potentiate the depressant effect of the substance chloropyramine on the central nervous system.

The medicine is incompatible with ethyl alcohol.

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Storage conditions

Chloropyramine hydrochloride should be kept in a dark place at a temperature not exceeding 25°C.

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Shelf life

Chloropyramine hydrochloride is allowed to be used for 2 years from the date of release of the drug.

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Reviews

Chloropyramine hydrochloride is a 1st generation antihistamine drug that is reversibly synthesized with H1 conductors. Because of this, to obtain a therapeutic effect, the drug must be taken in large doses, and because the effect of the drug has a short duration, the drug must be taken 4 times a day, and sometimes even 6.

Taking large doses of the drug leads to the development of a feeling of drowsiness, as well as a sedative effect (in some people, also to dizziness). It is these facts that are usually the reason for the appearance of negative reviews about the drug. Due to such an effect, it is necessary to limit the use of drugs in people whose work is associated with high coordination of movements, as well as rapid response. Therefore, doctors prescribing this drug are obliged to warn patients about the possibility of developing a sedative effect.

Rochloride is allowed to be used for 2 years from the date of release of the drug.