Bloody

Canison has a fungistatic and fungicidal effect (their development depends on the size of the applied dosages).

Indications Bloody

The cream is used to treat such disorders and pathologies:

• mycoses, affecting the epidermis, associated with a microflora that is sensitive to drugs;
• having mycosis origin lesions affecting the ears;
• having a fungal nature of infection in the scalp;
• erythrazia;
• lichen, having a multicolored or otrubrious character;
• mycoses, against which pyoderma is diagnosed.

Tablets are used in the following situations:

• vulvovaginitis ;
• superinfections in the vaginal area;
• candidiasis of urogenital character;
• the stage of preparation for the process of labor (for vaginal sanitation).

During the treatment of urethritis or infections in the genital area, there is also a pronounced effect on the use of drugs.

The cream is recommended to use in the treatment of dermatomycosis in the area of skin folds and hairy areas of the body.

Canison is used as an auxiliary drug in the treatment of trichomoniasis (an element of general chemotherapy).

[1], [2], [3], [4], [5], [6],

Release form

The drug is dispensed in the form of a cream (a tube having a volume of 20 g), a solution (flasks of 20 ml capacity), and in addition vaginal tablets (6 pieces inside the plate, and 1 applicator per pack).

[7]

Pharmacodynamics

Dimorphous and mold fungi, and in addition dermatophytes and blastomycetes with actinomycetes have a sensitivity to the drug.

The active element of the Canison slows down the binding of the molecules of the ergosterol component (it is necessary for the formation of membranes of fungal cells). Violation of the binding of this substance helps destroy cell membranes and alter the intracellular structure. As a result, the cells of the fungus die.

Together with this, clotrimazole has a retarding effect on peroxidases, potentiating the activity of oxidative processes inside cells.

The drug also has an antibacterial effect on staphylococci with corynebacteria and streptococci. In addition, it effectively affects and amoeba with Trichomonas.

[8], [9], [10], [11], [12], [13],

Pharmacokinetics

Canison has a high ability to pass through various layers of the epidermis. The drug has no resorptive properties.

After intravaginal application, only a local effect is observed, a minimal amount of the active element of the drug is absorbed through the vaginal mucosa.

[14], [15], [16], [17], [18]

Dosing and administration

Suppositories in the vagina are injected with a special applicator. It is pre-inserted suppository, after which it is deeply inserted into the vagina. After using this device, you should wash it thoroughly. The patient must remain in the lying position until the suppository completely dissolves.

The procedure is carried out 1-2 times per day. With a single injection of drugs per day, the procedure is recommended to be performed in the evening, before going to bed. Usually, this therapy lasts 6 days; If necessary, this course is allowed to be repeated.

When diagnosing the candida form of balanitis or vulvitis, it is necessary to combine tablets with a cream, which affects the affected areas 2-3 times a day.

One serving of the drug solution is 10-20 drops. This dosage is applied to the epidermis or mucous membranes in the lesions.

Diagram of the use of the cream.

The cream is applied only externally. Every day, a thin layer of it is applied to the infected area. Repeat this procedure should be 2-3 times a day. Before using the cream, it is necessary to clean and dry those areas that have been affected by the infection.

Therapy usually lasts 1 month. People with disruptive type of lichen need to apply the drug for 21 days, and those with mycosis in the area of the feet need to use the cream in the period of 14 days.

The duration of the treatment cycle is selected by the physician individually, but it is not recommended to conduct therapy with short courses, because this can subsequently lead to a relapse of the disease.

[32], [33], [34]

Use Bloody during pregnancy

Although there is no information about the negative effects of the drug on the body of pregnant women, it is prohibited to use it on the 1st and 2nd trimesters. Vaginal suppositories may be used before delivery, but only with the appointment of a doctor.

When breastfeeding, canisone can be used exclusively under constant medical supervision. It is forbidden to treat the breast and nipples with the drug.

Contraindications

Contraindicated use in persons with diagnosed hypersensitivity to clotrimazole or other medicamentous components.

[19], [20], [21], [22], [23], [24], [25],

Side effects Bloody

The use of medication can trigger the appearance of the following side-effects:

• reddening of the epidermis;
• headache;
• a feeling of tingling or burning, and itching;
• increased vaginal discharge;
• pain that occurs in the lower abdomen;
• swelling in the mucous membranes;
• irritation of the mucosa of the genitals after a sexual act.

[26], [27], [28], [29], [30], [31]

Interactions with other drugs

Canison loosens the therapeutic effect of amphotericin B, and besides this reduces the effectiveness of polyene antibiotics.

[35], [36], [37]

Storage conditions

The canister in tablets should be kept at temperature values within 15-25 ° C, and the cream at a temperature not exceeding 20 ° C.

[38]

Shelf life

Canison can be applied within 36 months from the date of manufacture of the drug.

Application for children

Do not prescribe medicines to children under 2 years of age. In the age group up to 12 years, the medicine is used cautiously, strictly observing medical indications.

[39], [40], [41]

Analogues

The analogues of the medication are Kandibene, Imidil and Triderm, and besides Candide with Clotrimazole and Antifungol.

[42], [43], [44]

Reviews

Canison gets good feedback from patients who leave their comments on medical forums. They indicate that the drug demonstrates effectiveness during treatment of dermatomycosis arising in the area of skin folds and hairy areas on the body.

It is also noted that the medicine copes with pathologies of fungal nature and allergic form of dermatitis. Negative symptoms during therapy with this medicine appear only occasionally.