Betaserk

Betaserc improves microcirculation processes.

[1], [2]

Indications Betaserka

Applies to such violations:

• Meniere's disease ;
• atherosclerosis in the cerebral artery, VBN and post-traumatic encephalopathy (part of the combined treatment);
• syndromes in which marked tinnitus, progressive hearing loss and vertigo (including those disorders or vestibular labyrinth nature edema in the inner ear, and in addition, vestibular neuronitis, internal otitis shape and having benign positional vertigo type).

Release form

Release of the medication is realized in tablets having a volume of 8, 16 or 24 mg. Inside the blister plate there are 10, 15, 20, 25 or 30 tablets.

Pharmacodynamics

Betaserc is a synthetic analogue of histamine. The mechanism of action of the beta-histidine element has not yet been fully investigated. There are a number of theories that were previously confirmed by clinical information:

• the active component of the drug is a partial stimulator of the H1-terminus of histamine, as well as a blocker of activity of histamine H3-endings of the vestibular HC centers;
• the drug improves the metabolic processes of histamine, as well as its release under the influence of the above factors;
• Betagistin increases the intensity of blood flow in the region of the inner ear by relaxing the vascular sphincters in this zone, and in addition enhances the processes of cerebrospinal microcirculation;
• the drug helps restore vestibular activity after neurrectomy in this area;
• depending on the size of the dosage, reduces the production of neural impulses within the vestibular nuclei.

The medicinal effect of betahistine is registered in people with Meniere's disease, as well as with dizziness of the vestibular nature. The effect was manifested in the weakening of the intensity and the reduction in the number of dizziness attacks occurring.

[3], [4], [5]

Pharmacokinetics

After oral administration, the active ingredient of the drug is absorbed inside the intestine and almost completely converted to a 2-pyridylacetic acid derivative. Blood levels of betahistin are rather low.

Admission along with food can slow the absorption process of the drug. Synthesis with blood protein is less than 5%. The Cmax values of 2-pyridylacetic acid within the blood are noted after 60 minutes after administration. The half-life is about 3.5 hours.

Disintegration products are excreted in the urine, but excretion of small amounts of betagistin is carried out through the intestines or kidneys.

[6], [7], [8]

Dosing and administration

Medication is consumed orally, along with food. Selection of the dosage portion is carried out individually, taking into account the response to the treatment demonstrated by the patient.

The daily adult dose is usually 24-28 mg (divided by 2-3 uses).

Sometimes the medicamentous influence of Betaserk develops only after 2-3 weeks of therapy, and a stable effect is observed only after several months of regular application of the drug.

[9]

Use Betaserka during pregnancy

To consume Betaserk in the 1st trimester or with lactation is prohibited. Admission to the 2-3th trimesters is allowed exclusively under the supervision of the doctor and if there are life indications.

Contraindications

The main contraindications:

• the presence of hypersensitivity to medicinal elements;
• feohromocytoma.

The drug should be used carefully (under the control of the doctor) people with bronchial asthma or ulcer.

Side effects Betaserka

Taking drugs can lead to the emergence of certain side-effects:

• digestive disorders: vomiting, flatulence, dyspepsia, nausea and abdominal pain;
• disorders of the NA function: headaches.
• signs of allergy: urticaria, anaphylaxis, rashes, angioedema and itching.

Overdose

Among the symptoms of poisoning: a mild form of nausea, a feeling of drowsiness and abdominal pain. More serious consequences (such as convulsions and cardiac reactions) developed at deliberate use in high dosages.

Symptomatic treatment procedures are used to eliminate symptoms.

Interactions with other drugs

When combining the drug with drugs blocking the activity of MAO, suppression of Betaserk's metabolism can be observed.

Betagistin is an analog of histamine, because of which it can not be ruled out that it will affect the effectiveness of substances-blockers of H1-terminal histamine.

[10]

Storage conditions

Betaserk must be kept out of the reach of children, dry place at standard temperature values.

Shelf life

Betaserk can be used within 5 years from the date of manufacture of the therapeutic agent.

Application for children

There is no information on the safety of use of Betaserik by persons under the age of 18, so it is forbidden to assign it to this category of patients.

Analogues

The analogues of the drug are the drugs Vertran, Betagistin, Denoyz, Asniton with Alfaserc and Microser, and in addition Betacentrine, Bataserc, Betaver, Vestinorm, Vasoserk with Vestibo, and Tagista and Vestikap.

Reviews

Betaserc receives good reviews from patients, as well as specialists. Often, people who treated with dizziness, accompanied by ear noise and VSD, say that there is no medicinal effect. According to people commenting on the forums, the medication rarely causes the appearance of negative symptoms.