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Last reviewed: 11.04.2020

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Berlipril is an ACE inhibitory medicine.

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Indications of the berliprila

It is used to treat such disorders:

  • elevated blood pressure;
  • heart failure;
  • a disorder in the work of the heart muscle, associated with a transferred myocardial infarction, and proceeding asymptomatically.

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Release form

Release in tablets.

Berlipril 10 contains 10 tablets per blister. Inside the package - 3, 5 or 10 blister plates.

Berlipril 20 is available in 10 tablets in a blister pack. The pack contains 3 blisters with tablets.

Berlipril 5 is available in quantities of 10 tablets inside the blister. In a separate pack contains 2, 3 or 5 or 10 such blister plates.

Berlipril plus 10/25 is produced by 10 tablets inside the blister pack. The pack contains 2 or 3 blister plates.


Berlipril (enalapril substance) is a representative of the ACEI category. After entering the body, it undergoes a hydrolysis process, in which an active ingredient, enalaprilate, is formed. It slows the action of the enzyme, which converts angiotensin I into the substance angiotensin II (this component has strong vasoconstrictor properties, and also promotes the production of aldosterone, which helps to trap water with Na ions inside the body).

In addition, enalaprilat slows the process of destruction of bradykinin, which has a vasodilating effect and increases the production of PG elements, which also have vasodilating properties. Due to the effect of the drug, the level of total peripheral resistance of blood vessels decreases. As a result, the index of blood pressure (both systolic and diastolic) decreases, and pre- and post-loading on the musculature of the heart decreases. In addition, enalaprilat improves coronary circulation and blood flow inside the kidneys.

The drug has an antihypertensive effect and prevents the progression of heart failure.



Regardless of food intake, 60% of the active ingredient is absorbed from the gastrointestinal tract. The drug is exposed to hepatic metabolism. Enalapril with enalaprilat is excreted mainly with the help of the kidneys, and the remainder is excreted by the intestine.


Use of the berliprila during pregnancy

It is contraindicated to prescribe Berlipril.


The main contraindications:

  • the presence of porphyria;
  • intolerance of the components of the drug;
  • lactation period;
  • children and adolescents less than 18 years old.

Use with caution in stenosis of the aortic aorta, hyperkalemia, stenosis of the mitral valve, bilateral stenosis of a.renalis, and in addition CEH and liver / kidney failure.

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Side effects of the berliprila

Taking tablets can cause these side effects:

  • a decrease in blood pressure (in the case of severe hypotension, myocardial infarction with angina may develop), development of PE, arrhythmia or cardialgia, as well as fainting;
  • sensation of drowsiness, anxiety, confusion, and in addition headaches, insomnia, depression, dizziness and the appearance of paresthesias;
  • ear noise, as well as hearing or vision disorders;
  • development of anorexia, diarrhea, vomiting, and also dryness of oral mucous membranes. Occasionally, hepatitis, pancreatitis or intestinal obstruction is observed;
  • the appearance of dry cough or bronchial spasms, the development of pharyngitis or rhinorrhea;
  • skin rash, Quincke's edema and Stevens-Johnson syndrome, and in addition itching, dermatitis, erythema multiforme, vasculitis with serositis, arthritis and stomatitis;
  • development of azotemia or renal dysfunction;
  • the appearance of eosinophilia, thrombocytopenia or neutropenia, and in addition anemia or agranulocytosis.

Side effects, which require the withdrawal of a medicine, arise only in rare cases.


Dosing and administration

The size of the initial daily dose of drugs in the case of treatment with an elevated blood pressure is 5 mg. If the desired effect was not achieved within 1-2 weeks, it is allowed to gradually increase the daily dosage to 40 mg. The average dose size is 10 mg. It is required to take the pill 1-2 times a day.

In chronic form of heart failure, it is necessary to start the course with the use of 2.5 mg per day. Further, the dosage is selected taking into account the parameters of blood pressure, as well as the patient's tolerance and the effectiveness of the drug. The size of the average daily dose is in the range of 5-20 mg - it can be used for 1 reception or divide by 2.

Older people are recommended to take the drug at an initial dose of 1.25 mg.

If the kidneys are deficient, the daily dose is adjusted, taking into account the QC level. At a rate of 80-30 ml / minute, a dosage of 5-10 mg is required, and in the case of a level of 30-10 ml / minute it is 2.5-5 mg. If the filtration rate is even lower than the indicated values, the drug is allowed to be used only during the days of hemodialysis procedures - in the amount of 1.25-2.5 mg.


As a result of an overdose, the patient develops a marked decrease in blood pressure, which can result in stupor, seizures, stroke with myocardial infarction, and thrombembolia.

To eliminate the violations, it is required to move the person to a horizontal position, and then perform a gastric lavage and give him sorbents. Further hemodialysis with infusion therapy is carried out and the substance angiotensin II is introduced.

Interactions with other drugs

NSAIDs weaken the antihypertensive properties of berlipril.

When combined with potassium-sparing diuretics (for example, with amiloride or triamterene, as well as spironolactone), it is possible to develop hyperkalemia.

Berlipril reduces the effectiveness of theophylline, and besides it slows down the elimination of lithium drugs.

The drug enhances the antihypertensive effects of methyldopa, diuretic drugs, prazosin, nitrates, b-adrenoblockers, as well as calcium channel blocking drugs and hydralazine.

In the case of a combination with immunosuppressants, allopurinol or cytostatics, potentiation of hematotoxic properties of drugs is observed.

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Storage conditions

Berlipril stored in standard conditions with a temperature of not more than 25 ° C.


Shelf life

Berlipril can be used in the 3 years since the manufacture of tablets.



To simplify the perception of information, this instruction for use of the drug "Berlipril" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.

Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.

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