Becloforte

Beclfort is an anti-asthmatic agent for inhalation. Consider the rules of its use, contraindications, dosage and more.

The inhaler contains an active substance from the group of glucocorticosteroids, which are effective for persistent asthma of any severity. Has a comprehensive mechanism of action. The anti-inflammatory effect is based on the stabilization of biological membranes, and the decrease in capillary permeability explains the anti-edematous properties of the drug. It has pronounced antiproliferative properties, inhibits proliferation and synthesis of fibroblasts, as well as sclerotic processes in the bronchial tree.

[1], [2], [3], [4], [5],

Indications Becloforte

The drug is used for prolonged preventive treatment of severe asthma in adults and children, as well as for patients who need systemic steroids to adequately control the symptoms of the disease. Indications for use Beclophort are based on an effective anti-inflammatory effect on the lungs. The medicine is the basis of a complex of prophylactic therapy of bronchial asthma.

[6], [7]

Release form

Beclofort has the form of release - a metered aerosol for inhalations. 1 dose of aerosol contains 250 μg of beclomethasone dipropionate (micronized) and 250 μg of auxiliary components: oleic acid, trichlorofluoromethane, dichlorodifluoromethane. One cylinder is designed for 200 dose-injections.

Pharmacodynamics

The active substance of the drug - beclomethasone dipropionate, is an analog of glucocorticosteroid receptors. Pharmacodynamics of the drug is associated with the hydrolysis of esterases and the formation of an active metabolite - beclomethasone-17-monopropionate, which has high anti-inflammatory activity.

[8], [9], [10], [11], [12]

Pharmacokinetics

Inhalation application Beclophort is associated with systemic absorption of active components through the lungs. Pharmacokinetics indicates a slight oral absorption of a single dose that has entered the digestive tract. During the absorption of the active components, beclomethasone dipropionate is transformed into the active metabolite beclomethasone-17-monopropionate. Bioavailability at 60%.

The medicine is rapidly excreted from the systemic circulation through metabolism. Volume distribution is moderate, binding to plasma proteins is 87%. The clearance of the active ingredient and its metabolite is about 150 l / h, the elimination half-life is 2.7 hours. 60% is excreted with feces, 12% with urine in the form of free metabolites.

[13], [14]

Dosing and administration

The anti-asthmatic is intended for inhalation. The method of application and dose Beclfort is prescribed by the attending physician, being guided by the patient's age, peculiarities of his organism and the course of the disease.

• For adults, children and elderly patients appoint 250 mcg 3-4 times a day. In severe cases, the dosage may be increased to 1500 μg / day. Once the therapeutic effect is achieved, the dosage should be reduced.
• For patients who require high doses of inhaled glucocorticosteroids, appoint 1000 micrograms per day. Dosage is adjusted depending on the individual reactions of the patient.

To achieve the optimal therapeutic effect, the drug must be applied on a regular basis. For the treatment to be effective, it is very important to use the inhaler correctly. Consider the rules of use:

1. Remove the cap of the mouthpiece by clamping its side faces.
2. Inside and outside the inhaler and in its cap there should be no outside objects.
3. Shake the bottle well. Take it so that the thumb is below the mouthpiece, the other fingers should hold the base of the can.
4. Take a deep breath, put the mouthpiece in your mouth, but do not bite.
5. Inhale through the mouth and click on the top of the inhaler to spray the drug. It is necessary to breathe deeply and slowly.
6. Hold your breath and take the inhaler out of your mouth.
7. If you need to do another pair of injections, wait 30-40 seconds and repeat the whole procedure again.

If during the inhalation the patient is difficult to synchronize breathing with the device, then it is necessary to additionally use a spacer.

[20], [21]

Use Becloforte during pregnancy

The possibility of using Beclofort during pregnancy is determined by the attending physician. It is necessary to consider not only the expected benefits for the mother, but also the potential risk to the fetus. The active components of the drug in small amounts are excreted in breast milk. Proceeding from this, the use of aerosol during lactation is undesirable.

Contraindications

The anti-asthmatic agent is contraindicated for use with individual intolerance to its components. Treatment of bronchial asthma should be carried out in stages. During therapy it is necessary to monitor the patient's condition by determining the parameters of the function of external respiration.

If the standard dosage does not stop astatic seizures and requires an increase, this indicates a progression of the disease. In this case, the need for the drug should be reviewed. The drug is contraindicated for relief of acute asthma attacks. To ease the acute condition, it is necessary to use high-speed inhalation bronchodilators. It is also contraindicated to abruptly stop treatment.

Beklofort is prescribed with special caution to patients with active and latent form of pulmonary tuberculosis, with fungal, bacterial and viral respiratory tract infections. Patients with anomalies of the lungs (bronchiectasis and pneumoconiosis) fall under the restriction, since there is a risk of fungal infection.

[15], [16], [17]

Side effects Becloforte

Incorrect use of the inhaler can cause adverse symptoms on the part of many organs and systems. Side effects of Beclophort are manifested by such reactions:

• Infection and invasion - candidiasis of the oral cavity and pharynx. Antifungal agents are used for treatment, but asthma therapy is not stopped.
• The immune system is urticaria, erythema, skin rash, angioedema, swelling of the face, oropharynx, various respiratory and anaphylactic reactions.
• Endocrine system - Cushing's syndrome, suppression of adrenal function, glaucoma, cataract, growth retardation in children and adolescents.
• Mental disorders - anxiety, sleep and behavior disorders, hyperactivity.
• Respiratory system - irritation of the throat and hoarseness of the voice, paradoxical bronchospasm.

If the side effects are severe, then you should seek medical help and adjust the dosage.

[18], [19]

Overdose

The use of doses exceeding the recommended dose may cause overdose symptoms. This manifests itself as a temporary depression of the adrenal cortex. Emergency care is not required, as the condition of the body is restored within a few days. In order to verify this, you can measure the level of cortisol in the blood plasma.

Interactions with other drugs

Beclophort can be used in the complex therapy of bronchial asthma. Interaction with other drugs is possible only on medical recommendations. The inhaler contains a small amount of ethanol, so when used in patients with hypersensitivity to this substance, there may be undesirable reactions when used concomitantly with Metronidazole or Disulfiram.

[22], [23]

Storage conditions

According to the storage conditions, Beclockfort should be kept in a place protected from sunlight and inaccessible to children. The recommended storage temperature is not higher than 30 ° C. Immediately after use, the inhaler should be closed with a cap. When using a cooled vial, the therapeutic effect of the drug is reduced.

Before the first use and with a break in treatment for more than 10 days, the cap of the mouthpiece needs to be removed by pressing on the sides, shake the bottle well and make a control spray into the air. This is necessary in order to ensure the operability of the device.

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Shelf life

Beclautfort must be used within 24 months from the date of its production. The expiration date is indicated on the cylinder and the carton of the preparation. At the end of this period, the vial must be disposed of. A balloon is contraindicated to break, pierce or burn, even if it is already fully used.