BALALUTAMID

Bicalutamide is an antiandrogenic medicine with antitumor properties.

[1], [2],

Indications Bikututamide

It is used for monotherapy and complex treatment for people with prostate carcinoma (combined with radiotherapy procedures or with radical prostatectomy for non-metastatic malignant tumors).

It may also be assigned to people who do not undergo the above procedures.

[3], [4]

Release form

The release of the drug is realized in tablets with a volume of 50 or 150 mg, in the amount of 14 pieces inside the cell plate. In the box - 28 or 280 tablets.

[5], [6], [7]

Pharmacodynamics

Bicalutamide has antiandrogenic properties and is non-steroidal. The substance has no other endocrine effect.

It is synthesized with androgenic endings and inhibits the stimulatory effect of androgens, while the activation of gene expression does not occur. Thanks to these processes, regression of malignant tumors in the prostate area is developing.

[8], [9], [10], [11],

Pharmacokinetics

The drug is at high speed and fully absorbed inside the gastrointestinal tract. Food does not affect this process.

Protein synthesis is 96%. Exchange processes are carried out in the liver. The half-life of a metabolic product is approximately 7 days.

Excretion of the drug occurs in the form of metabolic products - with urine and bile.

[12], [13], [14], [15],

Dosing and administration

For adults, a single oral administration of 50 mg of the drug per day is prescribed in combination with a surgical castration procedure or with an analogue of the LGRF component.

If there are no metastases of prostate carcinoma, for the treatment of a malignant tumor without surgical castration and the use of other medicines, use a single dose of 0.15 g of the substance per day.

The drug must be consumed over a long period (at least 2 years).

If a patient has severe disorders in the liver, a portion size adjustment is required.

[19]

Use Bikututamide during pregnancy

Women do not prescribe this medication.

Contraindications

Main contraindications:

• the presence of intolerance against the drug;
• combined use with cisapride, terfenadine or astemizole;
• hypolactasia or lack of lactase.

[16]

Side effects Bikututamide

Individuals develop signs of gynecomastia, as well as pain in the area of the mammary glands. Jaundice, asthenia, flushing, skin itching, diarrhea, vomiting, feeling of severe drowsiness or insomnia, and besides nausea, dizziness, dyspnea, headaches, heart failure and pain in the pelvic and sternum.

[17], [18],

Interactions with other drugs

Bicalutamide potentiates the effects of indirect anticoagulants.

It is not compatible with cisapride, astemizole, and terfenadine.

The drug increases the likelihood of negative signs in the case of use with cyclosporine and drugs that suppress the oxidative processes inside the microsomes (ketoconazole with cimetidine).

[20], [21]

Storage conditions

Bicalutamide is required to be kept protected from moisture. Temperature marks - within 25 ° C.

[22], [23], [24]

Shelf life

Bicalutamide can be used within 36 months of the production of a therapeutic drug.

[25]

Application for children

You can not assign Bicalutamide in pediatrics.

[26]

Analogs

Analogues of drugs are Kalumid, Bikalan, Casodex with Biculid, as well as Bicaluter and Bilumid.

[27], [28], [29], [30], [31]

Reviews

Bicalutamide for the most part receives positive reviews. In many patients, its use leads to the development of stable remission. But a large number of patients also noted the occurrence of jaundice, feelings of weakness, pain in the abdominal area and a decrease in hemoglobin values.